CCNA1 and RBL1

Number of citations of the paper that reports this interaction (PMID 10022926)
29

Data Source:
HPRD (in vitro, in vivo)

		CCNA1	RBL1
Gene Name		cyclin A1	retinoblastoma-like 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Microtubule Cytoskeleton	Nucleus Nucleoplasm Transcription Factor Complex
	Molecular Function	Protein Binding Protein Kinase Binding	Protein Binding Transcription Factor Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Mitotic Nuclear Division Male Meiosis I Spermatogenesis Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Division	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Viral Process Chromatin Modification Regulation Of Lipid Kinase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle
Pathways		Cellular Senescence G2/M Transition Cyclin E associated events during G1/S transition Orc1 removal from chromatin Cyclin A/B1 associated events during G2/M transition G2 Phase G1/S Transition G1/S-Specific Transcription Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication DNA Damage/Telomere Stress Induced Senescence Synthesis of DNA Regulation of DNA replication Senescence-Associated Secretory Phenotype (SASP) APC/C:Cdc20 mediated degradation of mitotic proteins G0 and Early G1 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes S Phase Regulation of APC/C activators between G1/S and early anaphase Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins SCF(Skp2)-mediated degradation of p27/p21 Orc1 removal from chromatin Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of mitotic cell cycle APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint SCF(Skp2)-mediated degradation of p27/p21 Cyclin A:Cdk2-associated events at S phase entry Mitotic G2-G2/M phases	Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Mitotic G1-G1/S phases TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer G0 and Early G1 Loss of Function of TGFBR1 in Cancer Cell Cycle, Mitotic Cyclin D associated events in G1 Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		34 interactors: ARID2 BRCA1 CABLES1 CDC20 CDC25A CDK1 CDK2 CDKN1A CDKN1B CKS1B CKS2 CUX1 E2F1 GNB2L1 GPS2 HIST1H1A HIST1H1B HIST1H2BA INCA1 KLHDC9 MCM4 MCM6 MYBL2 NPAT PGR PROCA1 RB1 RBL1 RBL2 RBM4 RPA1 SP1 SRC XRCC6	51 interactors: AOX1 BEGAIN BRCA1 BRF1 CCNA1 CCNA2 CCND1 CCNE1 CDK2 CDK4 CDK6 CEBPA CREG1 DGKZ DHX30 DYRK1A E2F4 E2F5 EPHA2 FN1 GOLGA2 HDAC1 ID2 IRF3 KDM5A LAMB2 MAPK6 MCM7 MYBL2 MYC NR2E3 NR4A1 NUCB1 PHB PLSCR1 PPP2R3A RBBP8 RBBP9 RINT1 SMAD2 SMAD3 SMAD4 SMARCA4 SNRPD3 SNW1 SP1 SUV39H1 SUV420H2 TAF1 TOP1 USP4
Entrez ID		8900	5933
HPRD ID		04946	00312
Ensembl ID		ENSG00000133101	ENSG00000080839
Uniprot IDs		P78396	P28749
PDB IDs			1H28
Enriched GO Terms of Interacting Partners?		Cell Cycle G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Regulation Of Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process Regulation Of Kinase Activity Chromosome Organization Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Organelle Organization Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Cell Cycle Checkpoint Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Negative Regulation Of Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Chromatin Organization Regulation Of Metabolic Process Macromolecule Biosynthetic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression DNA Damage Checkpoint Positive Regulation Of Metabolic Process DNA Replication Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Gene Expression DNA Conformation Change Cell Division Mitotic Cell Cycle Checkpoint Positive Regulation Of Transcription, DNA-templated Regulation Of Protein Phosphorylation Positive Regulation Of Cell Cycle Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of Transferase Activity Regulation Of Catalytic Activity Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Protein Metabolic Process	Transcription From RNA Polymerase II Promoter Cell Cycle Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription, Initiation Positive Regulation Of Cellular Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Gene Expression Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Metabolic Process Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Proliferation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Biosynthetic Process Cell Cycle Process Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Mitotic Cell Cycle Process Negative Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Multicellular Organismal Development
Tagcloud ?		asparaginase axis clustered confirming cure dexamethasone enhancement harboring hoxa infant lineage lymphoblastic meis1 mll nutlin oncogene orally recapitulate regimen regressions remission rg7112 translocations uncommon utility vincristine warrants xenograft xenografts	accounts adenocarcinoma applicable assist deaths diagnostics e2f6 effort expended facilitate gold hmga1 hnrpd interactome irf1 lung mirna nsclc qpcr screen silico sub suitable suv39h1 tf tfdp1 transcriptomics vital worldwide
Tagcloud (Difference) ?		asparaginase axis clustered confirming cure dexamethasone enhancement harboring hoxa infant lineage lymphoblastic meis1 mll nutlin oncogene orally recapitulate regimen regressions remission rg7112 translocations uncommon utility vincristine warrants xenograft xenografts	accounts adenocarcinoma applicable assist deaths diagnostics e2f6 effort expended facilitate gold hmga1 hnrpd interactome irf1 lung mirna nsclc qpcr screen silico sub suitable suv39h1 tf tfdp1 transcriptomics vital worldwide
Tagcloud (Intersection) ?