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MCM6 and NUDT2
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
MCM6
NUDT2
Description
minichromosome maintenance complex component 6
nudix hydrolase 2
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Chromosome
Cytosol
MCM Complex
CMG Complex
Mitochondrial Matrix
Molecular Function
Nucleotide Binding
DNA Binding
DNA Helicase Activity
Single-stranded DNA Binding
Helicase Activity
Protein Binding
ATP Binding
Hydrolase Activity
ATP Hydrolysis Activity
Identical Protein Binding
Single-stranded 3'-5' DNA Helicase Activity
Nucleotide Binding
Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) Activity
Protein Binding
GTP Binding
Bis(5'-nucleosyl)-tetraphosphatase Activity
Bis(5'-nucleosyl)-tetraphosphatase (symmetrical) Activity
Hydrolase Activity
Biological Process
Double-strand Break Repair Via Break-induced Replication
DNA Replication
DNA Replication Initiation
Regulation Of DNA-templated DNA Replication Initiation
Mitotic DNA Replication
Nucleobase-containing Compound Metabolic Process
AMP Biosynthetic Process
ATP Biosynthetic Process
Apoptotic Process
Cellular Response To Oxidative Stress
Pathways
Activation of ATR in response to replication stress
Unwinding of DNA
Assembly of the pre-replicative complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Switching of origins to a post-replicative state
Detoxification of Reactive Oxygen Species
Drugs
Diseases
GWAS
Aspartate aminotransferase levels (
33547301
)
Body fat percentage and LDL-C (pairwise) (
33619380
)
Body mass index (
25673413
)
Body mass index and LDL-C (pairwise) (
33619380
)
Gut microbiota (bacterial taxa, rank normal transformation method) (
32572223
)
Hip circumference (
25673412
)
Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes (
28736931
)
Fruit consumption (
32066663
)
Interacting Genes
36 interacting genes:
ATRIP
CATSPERT
CCNA1
CDC42
CDC7
CDKN2A
CDT1
CHEK1
CRLS1
DBF4
ESCO2
FAM161A
GMNN
HSPB1
IL36RN
ING5
MCM10
MCM2
MCM3
MCM4
MCM7
MCM8
MCMBP
MLLT3
MTDH
NUDT2
ORC1
ORC2
ORC4
ORC6
PSMA1
SCNM1
SMC1A
SNRPB2
UBE3A
ZBTB9
3 interacting genes:
DDIT4L
MCM6
PLEKHF2
Entrez ID
4175
318
HPRD ID
03485
04168
Ensembl ID
ENSG00000076003
ENSG00000164978
Uniprot IDs
Q14566
P50583
PDB IDs
2KLQ
2LE8
6XTX
6XTY
7PFO
7PLO
7W1Y
7W68
8B9D
8RWV
8S09
8S0A
8S0B
8S0D
8S0E
8S0F
8W0E
8W0F
8W0G
8W0I
9CAQ
1XSA
1XSB
1XSC
3U53
4ICK
4IJX
Enriched GO Terms of Interacting Partners
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DNA Replication
DNA Replication Initiation
DNA Metabolic Process
MCM Complex
Regulation Of DNA Replication
Regulation Of DNA-templated DNA Replication Initiation
Nuclear Origin Of Replication Recognition Complex
Nucleic Acid Metabolic Process
Double-strand Break Repair Via Break-induced Replication
Nucleoplasm
DNA Replication Origin Binding
Regulation Of DNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Single-stranded DNA Helicase Activity
Origin Recognition Complex
Chromosome, Telomeric Region
CMG Complex
Nucleus
Mitotic DNA Replication Initiation
DNA Repair
Chromosome
Single-stranded DNA Binding
Macromolecule Metabolic Process
Double-strand Break Repair Via Homologous Recombination
DNA Damage Response
Double-strand Break Repair
Recombinational Repair
Regulation Of Nuclear Cell Cycle DNA Replication
DNA Strand Elongation Involved In DNA Replication
Positive Regulation Of DNA-templated DNA Replication
Chromatin Binding
Helicase Activity
DNA Strand Elongation
DNA Recombination
Cellular Response To Stress
ATP Hydrolysis Activity
DNA Replication Preinitiation Complex Assembly
Regulation Of Cell Cycle Phase Transition
DNA Binding
Regulation Of Cell Cycle
DNA Helicase Activity
Negative Regulation Of Cell Cycle
Positive Regulation Of Nuclear Cell Cycle DNA Replication
Positive Regulation Of Chromatin Binding
Sister Chromatid Cohesion
Positive Regulation Of DNA Replication
Regulation Of Cell Cycle Process
Nucleotide Binding
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated DNA Replication
Single-stranded 3'-5' DNA Helicase Activity
Mitotic DNA Replication
CMG Complex
Double-strand Break Repair Via Break-induced Replication
Nuclear DNA Replication
MCM Complex
Regulation Of DNA-templated DNA Replication Initiation
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Tagcloud (Intersection)
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