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CCNA1 and WEE1
Number of citations of the paper that reports this interaction (PubMedID
19858290
)
61
Data Source:
BioGRID
(affinity chromatography technology, pull down)
CCNA1
WEE1
Description
cyclin A1
WEE1 G2 checkpoint kinase
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Microtubule Organizing Center
Cytosol
Microtubule Cytoskeleton
Cyclin A1-CDK1 Complex
Cyclin A1-CDK2 Complex
Cyclin A2-CDK2 Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Molecular Function
Protein Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Nucleotide Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Male Meiosis I
Spermatogenesis
Cell Division
G2/M Transition Of Mitotic Cell Cycle
Microtubule Cytoskeleton Organization
Mitotic Cell Cycle
Nuclear Envelope Organization
Mitotic Nuclear Membrane Disassembly
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Establishment Of Cell Polarity
Positive Regulation Of DNA Replication
Neuron Projection Morphogenesis
Cell Division
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
G0 and Early G1
Telomere Extension By Telomerase
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Ub-specific processing proteases
Processing of DNA double-strand break ends
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
G2 Phase
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G1/S-Specific Transcription
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Polo-like kinase mediated events
Cyclin E associated events during G1/S transition
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
Cyclin A:Cdk2-associated events at S phase entry
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Factors involved in megakaryocyte development and platelet production
Drugs
9-HYDROXY-4-PHENYL-6H-PYRROLO[3,4-C]CARBAZOLE-1,3-DIONE
9-HYDROXY-6-(3-HYDROXYPROPYL)-4-(2-METHOXYPHENYL)PYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE
N-[4-(2-CHLOROPHENYL)-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-C]CARBAZOL-9-YL]FORMAMIDE
4-(2-chlorophenyl)-8-(2-hydroxyethyl)-6-methylpyrrolo[3,4-e]indole-1,3(2H,6H)-dione
3-(9-HYDROXY-1,3-DIOXO-4-PHENYL-2,3-DIHYDROPYRROLO[3,4-C]CARBAZOL-6(1H)-YL)PROPANOIC ACID
8-bromo-4-(2-chlorophenyl)-N-(2-hydroxyethyl)-6-methyl-1,3-dioxo-1,2,3,6-tetrahydropyrrolo[3,4-e]indole-7-carboxamide
MK-1775
Fostamatinib
Diseases
GWAS
Cocaine dependence (
31212010
)
Nickel levels (
26025379
)
Cutaneous squamous cell carcinoma (
32041948
)
Emphysema annual change measurement in smokers (adjusted lung density) (
31324189
)
Platelet distribution width (
32888494
)
Interacting Genes
40 interacting genes:
ANAPC4
ARID2
BRCA1
BRCA2
CABLES1
CDC20
CDC25A
CDK1
CDK2
CDKN1A
CDKN1B
CKS1B
CKS2
CUX1
E2F1
FZR1
GPS2
H1-1
H1-5
H2BC1
INCA1
KLHDC9
MCM4
MCM6
MYBL2
NPAT
PGR
PROCA1
PSMA2
RACK1
RB1
RBL1
RBL2
RBM4
RPA1
SP1
SRC
TRIM13
WEE1
XRCC6
27 interacting genes:
AKT1
BRD8
BRSK1
BRSK2
BTRC
CASP3
CCNA1
CCNB1
CDC14A
CDCA3
CDK1
CDK2
CRK
CSNK2A1
EPS15
ERRFI1
FBXW11
MAILR
NEDD4
PIN1
PLK1
SKP2
SMAD3
SMURF1
YWHAB
YWHAG
YWHAZ
Entrez ID
8900
7465
HPRD ID
04946
01907
Ensembl ID
ENSG00000133101
ENSG00000166483
Uniprot IDs
A0A140VJG0
P78396
P30291
Q86V29
PDB IDs
1X8B
2IN6
2IO6
2Z2W
3BI6
3BIZ
3CQE
3CR0
5V5Y
5VC3
5VC4
5VC5
5VC6
5VD2
5VD4
5VD5
5VD7
5VD8
5VD9
5VDA
7N3U
8BJU
8WDK
Enriched GO Terms of Interacting Partners
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Cyclin Binding
Regulation Of Mitotic Cell Cycle
Nucleoplasm
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle
Negative Regulation Of Cell Cycle
Negative Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle Process
Negative Regulation Of Cell Cycle Phase Transition
Cell Cycle Phase Transition
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Primary Metabolic Process
Negative Regulation Of Cell Cycle Process
Regulation Of DNA Metabolic Process
Mitotic Cell Cycle Phase Transition
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of DNA Replication
Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of DNA Replication
Nucleus
Cell Cycle G1/S Phase Transition
Signal Transduction In Response To DNA Damage
Regulation Of Catalytic Activity
Cell Division
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Chromosome Organization
Regulation Of Kinase Activity
Regulation Of Metabolic Process
Chromosome, Telomeric Region
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G2/M Phase Transition
Negative Regulation Of Cell Cycle G1/S Phase Transition
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Phosphorylation
Regulation Of Lipid Kinase Activity
Cyclin-dependent Protein Kinase Holoenzyme Complex
DNA Damage Checkpoint Signaling
G2/M Transition Of Mitotic Cell Cycle
DNA Damage Response
Regulation Of Protein Modification Process
Cellular Response To Stress
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Cell Cycle G2/M Phase Transition
Positive Regulation Of DNA Metabolic Process
Cell Cycle G2/M Phase Transition
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Phosphoserine Residue Binding
Protein Modification Process
Post-translational Protein Modification
Regulation Of Cell Cycle
Regulation Of Protein Localization To Nucleus
Regulation Of Protein Stability
Intracellular Signal Transduction
Regulation Of Protein Metabolic Process
Cytosol
Protein Metabolic Process
Organelle Organization
Positive Regulation Of Protein Metabolic Process
Protein Catabolic Process
Cellular Response To Stress
Protein Targeting
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Protein Localization
Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Regulation Of Protein Catabolic Process
Protein Localization To Site Of Double-strand Break
Signal Transduction
G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Metabolic Process
Protein Polyubiquitination
Macromolecule Catabolic Process
Regulation Of Signaling
Cell Cycle G1/S Phase Transition
Protein Ubiquitination
Regulation Of Cell Cycle Phase Transition
Cytoplasm
Microtubule Cytoskeleton Organization
Cell Division
Protein Kinase Binding
Protein Localization To Organelle
Response To Stress
DNA Damage Checkpoint Signaling
Proteasomal Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Peptidyl-serine Phosphorylation
Protein Modification By Small Protein Conjugation
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Mitotic Cell Cycle Phase Transition
Intracellular Protein Localization
Regulation Of Mitotic Cell Cycle
Protein Phosphorylation
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Tagcloud (Intersection)
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