MCM6 and MCM8

Number of citations of the paper that reports this interaction (PubMedID 12771218)
35

Data Source:
HPRD (in vivo)

		MCM6	MCM8
Description		minichromosome maintenance complex component 6	minichromosome maintenance 8 homologous recombination repair factor
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytosol MCM Complex CMG Complex	Nucleus Nucleoplasm Chromosome MCM Complex MCM8-MCM9 Complex
	Molecular Function	Nucleotide Binding DNA Binding DNA Helicase Activity Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Identical Protein Binding Single-stranded 3'-5' DNA Helicase Activity	Nucleotide Binding DNA Binding Chromatin Binding Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Enzyme Binding MutLbeta Complex Binding MutSalpha Complex Binding MutSbeta Complex Binding
	Biological Process	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Regulation Of DNA-templated DNA Replication Initiation Mitotic DNA Replication	Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair DNA Damage Response Female Gamete Generation Recombinational Interstrand Cross-link Repair Male Gamete Generation Protein Stabilization Mismatch Repair Involved In Maintenance Of Fidelity Involved In DNA-dependent DNA Replication Protein Localization To Chromatin
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Unwinding of DNA CDC6 association with the ORC:origin complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Body fat percentage and LDL-C (pairwise) ( 33619380) Body mass index ( 25673413) Body mass index and LDL-C (pairwise) ( 33619380) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hip circumference ( 25673412) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)	Breast cancer ( 29059683) Estradiol levels ( 34255042) HIV-1 viral setpoint ( 20205591) Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 19448619 22267201 26414677 29773799) Preeclampsia ( 23551011) Uterine fibroids ( 30194396 31649266)
Interacting Genes		36 interacting genes: ATRIP CATSPERT CCNA1 CDC42 CDC7 CDKN2A CDT1 CHEK1 CRLS1 DBF4 ESCO2 FAM161A GMNN HSPB1 IL36RN ING5 MCM10 MCM2 MCM3 MCM4 MCM7 MCM8 MCMBP MLLT3 MTDH NUDT2 ORC1 ORC2 ORC4 ORC6 PSMA1 SCNM1 SMC1A SNRPB2 UBE3A ZBTB9	4 interacting genes: FEM1C MCM4 MCM6 MCM7
Entrez ID		4175	84515
HPRD ID		03485	12186
Ensembl ID		ENSG00000076003	ENSG00000125885
Uniprot IDs		Q14566	B4DN82 Q9UJA3
PDB IDs		2KLQ 2LE8 6XTX 6XTY 7PFO 7PLO 7W1Y 7W68 8B9D 8RWV 8S09 8S0A 8S0B 8S0D 8S0E 8S0F 8W0E 8W0F 8W0G 8W0I 9CAQ	6L0O 7DP3 7WI7 7YOX 8S91 8S92 8S94
Enriched GO Terms of Interacting Partners?		DNA Replication DNA Replication Initiation DNA Metabolic Process MCM Complex Regulation Of DNA Replication Regulation Of DNA-templated DNA Replication Initiation Nuclear Origin Of Replication Recognition Complex Nucleic Acid Metabolic Process Double-strand Break Repair Via Break-induced Replication Nucleoplasm DNA Replication Origin Binding Regulation Of DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Single-stranded DNA Helicase Activity Origin Recognition Complex Chromosome, Telomeric Region CMG Complex Nucleus Mitotic DNA Replication Initiation DNA Repair Chromosome Single-stranded DNA Binding Macromolecule Metabolic Process Double-strand Break Repair Via Homologous Recombination DNA Damage Response Double-strand Break Repair Recombinational Repair Regulation Of Nuclear Cell Cycle DNA Replication DNA Strand Elongation Involved In DNA Replication Positive Regulation Of DNA-templated DNA Replication Chromatin Binding Helicase Activity DNA Strand Elongation DNA Recombination Cellular Response To Stress ATP Hydrolysis Activity DNA Replication Preinitiation Complex Assembly Regulation Of Cell Cycle Phase Transition DNA Binding Regulation Of Cell Cycle DNA Helicase Activity Negative Regulation Of Cell Cycle Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Chromatin Binding Sister Chromatid Cohesion Positive Regulation Of DNA Replication Regulation Of Cell Cycle Process Nucleotide Binding Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated DNA Replication	CMG Complex Double-strand Break Repair Via Break-induced Replication MCM Complex Regulation Of DNA-templated DNA Replication Initiation DNA Replication Initiation DNA Helicase Activity Single-stranded DNA Binding Regulation Of DNA Replication Helicase Activity Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Replication DNA Strand Elongation Involved In DNA Replication Chromosome, Telomeric Region Single-stranded DNA Helicase Activity DNA Strand Elongation Double-strand Break Repair DNA Recombination ATP Hydrolysis Activity Regulation Of DNA Metabolic Process DNA Repair Chromosome DNA Metabolic Process DNA Damage Response Single-stranded 3'-5' DNA Helicase Activity Mitotic DNA Replication Mitotic DNA Replication Initiation Nuclear DNA Replication ATP Binding Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Nucleoplasm Cellular Response To Stress Hydrolase Activity Nucleotide Binding Cul2-RING Ubiquitin Ligase Complex Nucleic Acid Metabolic Process Macromolecule Metabolic Process DNA Binding Nucleobase-containing Compound Metabolic Process DNA-templated DNA Replication Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Cellular Response To Xenobiotic Stimulus Response To Stress Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Complex
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