CCNA1 and CDC20

Number of citations of the paper that reports this interaction (PMID 19477924)
15

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology)

		CCNA1	CDC20
Gene Name		cyclin A1	cell division cycle 20
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Microtubule Cytoskeleton	Spindle Pole Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Centrosome Spindle Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Protein Kinase Binding	Protein Binding Protein C-terminus Binding Enzyme Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Mitotic Nuclear Division Male Meiosis I Spermatogenesis Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Division	Mitotic Cell Cycle Cell Cycle Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Positive Regulation Of Cell Proliferation Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Synaptic Plasticity Regulation Of Meiosis Regulation Of Dendrite Development Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Activation Of Anaphase-promoting Complex Activity Positive Regulation Of Synapse Maturation
Pathways		Cellular Senescence G2/M Transition Cyclin E associated events during G1/S transition Orc1 removal from chromatin Cyclin A/B1 associated events during G2/M transition G2 Phase G1/S Transition G1/S-Specific Transcription Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication DNA Damage/Telomere Stress Induced Senescence Synthesis of DNA Regulation of DNA replication Senescence-Associated Secretory Phenotype (SASP) APC/C:Cdc20 mediated degradation of mitotic proteins G0 and Early G1 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes S Phase Regulation of APC/C activators between G1/S and early anaphase Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins SCF(Skp2)-mediated degradation of p27/p21 Orc1 removal from chromatin Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of mitotic cell cycle APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint SCF(Skp2)-mediated degradation of p27/p21 Cyclin A:Cdk2-associated events at S phase entry Mitotic G2-G2/M phases	Mitotic Prometaphase APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Phosphorylation of Emi1 Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Resolution of Sister Chromatid Cohesion SCF-beta-TrCP mediated degradation of Emi1 Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		34 interactors: ARID2 BRCA1 CABLES1 CDC20 CDC25A CDK1 CDK2 CDKN1A CDKN1B CKS1B CKS2 CUX1 E2F1 GNB2L1 GPS2 HIST1H1A HIST1H1B HIST1H2BA INCA1 KLHDC9 MCM4 MCM6 MYBL2 NPAT PGR PROCA1 RB1 RBL1 RBL2 RBM4 RPA1 SP1 SRC XRCC6	37 interactors: ANAPC1 ANAPC10 ANAPC2 ANAPC5 ANAPC7 APP AURKA BUB1 BUB1B CCNA1 CCNA2 CCNB1 CDC16 CDC27 CDC6 CDR2 CDT1 FBXO5 FZR1 HDAC1 HDAC2 HSF1 HSF2 MAD2L1 MAD2L2 PIM1 PLK1 PTTG1 RASSF1 SIRT2 SOSTDC1 SPATC1 TCP1 TGFBR1 TK1 UBE2C UBE2S
Entrez ID		8900	991
HPRD ID		04946	04686
Ensembl ID		ENSG00000133101	ENSG00000117399
Uniprot IDs		P78396	Q12834
PDB IDs			4GGA 4GGC 4GGD
Enriched GO Terms of Interacting Partners?		Cell Cycle G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Regulation Of Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process Regulation Of Kinase Activity Chromosome Organization Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Organelle Organization Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Cell Cycle Checkpoint Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Negative Regulation Of Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Chromatin Organization Regulation Of Metabolic Process Macromolecule Biosynthetic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression DNA Damage Checkpoint Positive Regulation Of Metabolic Process DNA Replication Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Gene Expression DNA Conformation Change Cell Division Mitotic Cell Cycle Checkpoint Positive Regulation Of Transcription, DNA-templated Regulation Of Protein Phosphorylation Positive Regulation Of Cell Cycle Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of Transferase Activity Regulation Of Catalytic Activity Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Protein Metabolic Process	Regulation Of Cell Cycle Mitotic Nuclear Division Regulation Of Cell Cycle Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Segregation Cell Division Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Cycle Process Regulation Of Mitotic Sister Chromatid Separation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Regulation Of Protein Ubiquitination Negative Regulation Of Chromosome Segregation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Division Negative Regulation Of Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Cell Cycle Cell Cycle Checkpoint Regulation Of Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Ligase Activity Negative Regulation Of Chromosome Organization Protein K11-linked Ubiquitination Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Tagcloud ?		asparaginase axis clustered confirming cure dexamethasone enhancement harboring hoxa infant lineage lymphoblastic meis1 mll nutlin oncogene orally recapitulate regimen regressions remission rg7112 translocations uncommon utility vincristine warrants xenograft xenografts	abrogates anaphase apc assembles attached bub3 bubr1 centrally checkpoint comet correctly cyclosome delays disassemble disassembled disassembly hela hydrolysis inactivated mad2 mcc mitotic p31 participates spindle subcomplex sufficiently trip13 turned
Tagcloud (Difference) ?		asparaginase axis clustered confirming cure dexamethasone enhancement harboring hoxa infant lineage lymphoblastic meis1 mll nutlin oncogene orally recapitulate regimen regressions remission rg7112 translocations uncommon utility vincristine warrants xenograft xenografts	abrogates anaphase apc assembles attached bub3 bubr1 centrally checkpoint comet correctly cyclosome delays disassemble disassembled disassembly hela hydrolysis inactivated mad2 mcc mitotic p31 participates spindle subcomplex sufficiently trip13 turned
Tagcloud (Intersection) ?