CCNA1 and ANAPC4

Number of citations of the paper that reports this interaction (PubMedID 25859049)
29

Data Source:
BioGRID (pull down)

		CCNA1	ANAPC4
Description		cyclin A1	anaphase promoting complex subunit 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Microtubule Cytoskeleton Cyclin A1-CDK1 Complex Cyclin A1-CDK2 Complex Cyclin A2-CDK2 Complex	Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol Nuclear Periphery
	Molecular Function	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity	Ubiquitin-protein Transferase Activity Protein Binding Protein Phosphatase Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Male Meiosis I Spermatogenesis Cell Division	Regulation Of Mitotic Cell Cycle Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination
Pathways		G0 and Early G1 Telomere Extension By Telomerase Cdc20:Phospho-APC/C mediated degradation of Cyclin A Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Ub-specific processing proteases Processing of DNA double-strand break ends TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation G2 Phase Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G1/S-Specific Transcription Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Cocaine dependence ( 31212010) Nickel levels ( 26025379)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Body mass index ( 29273807) Body size at age 10 ( 32376654) General cognitive ability ( 29844566) Heel bone mineral density ( 30598549) Intelligence (MTAG) ( 29326435) Logical memory (immediate recall) in normal cognition ( 29274321) Multisite chronic pain ( 31194737) Waist circumference adjusted for body mass index ( 34021172) Weight ( 20966902)
Interacting Genes		40 interacting genes: ANAPC4 ARID2 BRCA1 BRCA2 CABLES1 CDC20 CDC25A CDK1 CDK2 CDKN1A CDKN1B CKS1B CKS2 CUX1 E2F1 FZR1 GPS2 H1-1 H1-5 H2BC1 INCA1 KLHDC9 MCM4 MCM6 MYBL2 NPAT PGR PROCA1 PSMA2 RACK1 RB1 RBL1 RBL2 RBM4 RPA1 SP1 SRC TRIM13 WEE1 XRCC6	5 interacting genes: CCNA1 MAD2L1BP PTTG1 UBE2I UBE2S
Entrez ID		8900	29945
HPRD ID		04946	09505
Ensembl ID		ENSG00000133101	ENSG00000053900
Uniprot IDs		A0A140VJG0 P78396	B3KN47 Q9UJX5
PDB IDs			4UI9 5A31 5BPW 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW
Enriched GO Terms of Interacting Partners?		Cyclin Binding Regulation Of Mitotic Cell Cycle Nucleoplasm Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Primary Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of DNA Metabolic Process Mitotic Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Replication Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA Replication Nucleus Cell Cycle G1/S Phase Transition Signal Transduction In Response To DNA Damage Regulation Of Catalytic Activity Cell Division Regulation Of G2/M Transition Of Mitotic Cell Cycle Chromosome Organization Regulation Of Kinase Activity Regulation Of Metabolic Process Chromosome, Telomeric Region Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Phosphorylation Regulation Of Lipid Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle DNA Damage Response Regulation Of Protein Modification Process Cellular Response To Stress Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Cell Cycle G2/M Phase Transition Positive Regulation Of DNA Metabolic Process	Cell Division SUMO Conjugating Enzyme Activity O-phosphoseryl-tRNA(Sec) Selenium Transferase Activity Conversion Of Seryl-tRNAsec To Selenocys-tRNAsec Cyclin A1-CDK1 Complex Cyclin A1-CDK2 Complex RING-like Zinc Finger Domain Binding Chromosome Segregation SUMO Ligase Complex Small Protein Activating Enzyme Binding HLH Domain Binding Mitotic Cell Cycle Phase Transition Cyclin A2-CDK2 Complex Cell Cycle Phase Transition Homologous Chromosome Segregation Deactivation Of Mitotic Spindle Assembly Checkpoint Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling Positive Regulation Of Ubiquitin Protein Ligase Activity Nucleus Free Ubiquitin Chain Polymerization Selenocysteine Incorporation Positive Regulation Of Mitotic Sister Chromatid Segregation Anaphase-promoting Complex Binding Mitotic Nuclear Membrane Reassembly Protein K29-linked Ubiquitination Transferase Complex Positive Regulation Of Ubiquitin-protein Transferase Activity Meiotic Chromosome Segregation Exit From Mitosis Regulation Of Exit From Mitosis Protein K27-linked Ubiquitination Positive Regulation Of Mitotic Metaphase/anaphase Transition Ubiquitin-like Protein Transferase Activity Transcription Factor Binding SUMO Transferase Activity Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex Synaptonemal Complex Nuclear Membrane Reassembly Molecular Function Activator Activity Protein K6-linked Ubiquitination Regulation Of Ubiquitin-protein Transferase Activity Male Meiosis I Presynaptic Cytosol Postsynaptic Cytosol Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Positive Regulation Of Chromosome Segregation Male Gamete Generation
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