MCM5 and NFKBIA

Number of citations of the paper that reports this interaction (PubMedID 14743216)
0

Data Source:
HPRD (in vivo)

		MCM5	NFKBIA
Description		minichromosome maintenance complex component 5	NFKB inhibitor alpha
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Membrane MCM Complex CMG Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane I-kappaB/NF-kappaB Complex
	Molecular Function	Nucleotide Binding DNA Binding DNA Replication Origin Binding Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity 3'-5' DNA Helicase Activity	Protein Binding Nuclear Localization Sequence Binding Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding NF-kappaB Binding Protein Sequestering Activity Transcription Regulator Inhibitor Activity
	Biological Process	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Regulation Of DNA-templated DNA Replication Initiation	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Inflammatory Response Notch Signaling Pathway Canonical NF-kappaB Signal Transduction Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Signal Transduction Involved In Regulation Of Gene Expression Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cholesterol Transport Response To Muramyl Dipeptide Response To Lipopolysaccharide Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Muscle Stretch Non-canonical NF-kappaB Signal Transduction Regulation Of Cell Population Proliferation Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Canonical NF-kappaB Signal Transduction Response To Exogenous DsRNA Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response B Cell Receptor Signaling Pathway Positive Regulation Of Transcription Initiation By RNA Polymerase II Cellular Response To Cold Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Interleukin-1-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Cellular Response To Tumor Necrosis Factor Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation SUMOylation of immune response proteins IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling Ub-specific processing proteases Interleukin-1 signaling TRAF6 mediated NF-kB activation SARS-CoV-1 activates/modulates innate immune responses Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs			Acetylsalicylic acid Bardoxolone methyl Astaxanthin
Diseases			Hodgkin lymphoma Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect
GWAS		Chronotype ( 30696823) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Appendicular lean mass ( 33097823) Asthma ( 32296059 30929738) Asthma (childhood onset) ( 30929738) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Creatine kinase levels ( 29403010) Eczema ( 31361310) Hip circumference adjusted for BMI ( 25673412) Inflammatory skin disease ( 25574825) Lymphocyte count ( 32888494 27863252) PR interval ( 32439900) Psoriasis ( 20953190 25903422 25854761 25574825 23143594 20953189) Psoriasis vulgaris ( 26626624) Pulse pressure ( 30578418 27841878) Rheumatoid arthritis ( 32723749) Systolic blood pressure ( 28739976 27841878 30578418) White blood cell count ( 32888494)
Interacting Genes		30 interacting genes: APP ATRIP CDC5L CDC7 CDKN2A CEBPA EP300 ESCO2 FBXO7 KRTAP10-7 LMNA MCM2 MCM3 MCM7 MCMBP MCPH1 MDFI NFKBIA NUDT3 ORC1 ORC2 ORC3 ORC5 ORC6 PTEN RBPMS RPA2 STAT1 TRIM28 YWHAG	92 interacting genes: ABL1 ARRB1 ARRB2 ATF4 AURKA BARD1 BTRC CAPN1 CAPN2 CD7 CDC34 CHUK COMMD1 COPS8 CSNK2A1 CUL1 DNAJA3 DYNLL1 EIF2AK2 ELP1 ENKD1 FBXW11 G3BP2 HDAC1 HDAC3 HNRNPA1 HOXA9 HOXB7 HSPB1 IKBKB IKBKE IKBKG IKZF4 ITPK1 JAK2 LCK LYL1 MAP3K1 MAP3K14 MAP3K2 MAP3K3 MAP3K7 MCM5 MCM7 MED19 NCOR2 NEDD9 NFKB1 NFKB2 NFKBIB NKIRAS1 NKIRAS2 PIK3R1 PIR POLR2C POM121 PRKCA PRKCI PSMA2 PSMD3 PTPN1 PTPN13 REL RELA RNF115 RPS6KA1 RPS6KA3 RWDD3 SKP1 SLC25A4 SLC25A5 SRC ST7 SUMO1 SUMO4 TBK1 TCL1A TNF TNFSF11 TP53 TUBA1B UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2I UBE2L3 UBE2M UBE2S USP39 VCP ZNF212
Entrez ID		4174	4792
HPRD ID		04075	01235
Ensembl ID		ENSG00000100297	ENSG00000100906
Uniprot IDs		B1AHB0 P33992	P25963
PDB IDs		6XTX 6XTY 7PFO 7PLO 7W1Y 7W68 8B9D 8S09 8S0A 8S0B 8S0D 8S0E 8S0F 8W0E 8W0F 8W0G 8W0I 9CAQ	1IKN 1NFI 6TTU 6Y1J
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation Nuclear Origin Of Replication Recognition Complex DNA Replication Origin Recognition Complex DNA Metabolic Process Nucleoplasm Nucleic Acid Metabolic Process DNA Replication Origin Binding Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Metabolic Process Chromosome, Telomeric Region Regulation Of DNA Replication Nucleobase-containing Compound Metabolic Process MCM Complex Double-strand Break Repair Via Break-induced Replication Regulation Of Primary Metabolic Process Cellular Response To Stress Macromolecule Metabolic Process Response To Stress Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle DNA Repair Regulation Of Protein Localization To Nucleus DNA Damage Response Regulation Of Cell Cycle Phase Transition CMG Complex Regulation Of Cell Cycle Chromatin Double-strand Break Repair Negative Regulation Of Cell Cycle Phase Transition Regulation Of DNA-templated DNA Replication Initiation Regulation Of Cell Cycle Process DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination Single-stranded DNA Helicase Activity Recombinational Repair Negative Regulation Of Cell Cycle Process Protein Localization To Organelle Mitotic DNA Replication Initiation Identical Protein Binding Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Intracellular Signal Transduction NF-kappaB Binding Regulation Of Protein Stability Single-stranded DNA Binding Negative Regulation Of DNA-templated Transcription	Regulation Of Canonical NF-kappaB Signal Transduction Nucleoplasm Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Protein Modification Process Cytosol Nucleus Positive Regulation Of Macromolecule Metabolic Process Intracellular Signal Transduction Regulation Of Metabolic Process Canonical NF-kappaB Signal Transduction Macromolecule Metabolic Process Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Non-canonical NF-kappaB Signal Transduction Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process ATP Binding Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Modification-dependent Protein Catabolic Process Protein Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Signal Transduction Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Negative Regulation Of Intracellular Signal Transduction Nucleotide Binding Intracellular Signaling Cassette Negative Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Negative Regulation Of Cell Communication Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Modification By Small Protein Conjugation Protein Kinase Activity Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Macromolecule Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of DNA-templated Transcription Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?