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MCM5 and ORC3
Number of citations of the paper that reports this interaction (PMID
15232106
)
88
Data Source:
HPRD
(in vitro)
MCM5
ORC3
Gene Name
minichromosome maintenance complex component 5
origin recognition complex, subunit 3
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Membrane
MCM Complex
Origin Recognition Complex
Nucleoplasm
Nuclear Origin Of Replication Recognition Complex
Molecular Function
DNA Binding
DNA Helicase Activity
Protein Binding
ATP Binding
DNA Replication Origin Binding
Protein Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
DNA Replication
DNA Replication Initiation
DNA Strand Elongation Involved In DNA Replication
DNA Duplex Unwinding
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
DNA Replication
Neural Precursor Cell Proliferation
Pathways
Synthesis of DNA
G2/M Checkpoints
Activation of the pre-replicative complex
DNA Replication Pre-Initiation
M/G1 Transition
Regulation of DNA replication
Activation of the pre-replicative complex
Orc1 removal from chromatin
S Phase
DNA strand elongation
Cell Cycle, Mitotic
Assembly of the pre-replicative complex
Orc1 removal from chromatin
G1/S Transition
Activation of ATR in response to replication stress
Cell Cycle Checkpoints
Removal of licensing factors from origins
Mitotic G1-G1/S phases
Switching of origins to a post-replicative state
Unwinding of DNA
G2/M Checkpoints
Activation of the pre-replicative complex
Activation of the pre-replicative complex
Orc1 removal from chromatin
Assembly of the pre-replicative complex
Activation of ATR in response to replication stress
G1/S Transition
Assembly of the ORC complex at the origin of replication
Removal of licensing factors from origins
Mitotic G1-G1/S phases
Switching of origins to a post-replicative state
E2F mediated regulation of DNA replication
Synthesis of DNA
DNA Replication Pre-Initiation
Regulation of DNA replication
M/G1 Transition
S Phase
CDC6 association with the ORC:origin complex
Cell Cycle, Mitotic
Orc1 removal from chromatin
E2F-enabled inhibition of pre-replication complex formation
Cell Cycle Checkpoints
Association of licensing factors with the pre-replicative complex
CDT1 association with the CDC6:ORC:origin complex
Drugs
Diseases
GWAS
Obesity-related traits (
23251661
)
Protein-Protein Interactions
20 interactors:
APP
CDC5L
CDC7
CDKN2A
KRTAP10-7
MCM2
MCM3
MCM7
MDFI
NFKBIA
NUDT3
ORC1
ORC2
ORC3
ORC5
ORC6
RBPMS
RPA2
STAT1
YWHAG
18 interactors:
APP
CCNE2
CDC45
CDC6
CDK4
DBF4
HIST3H3
HIST4H4
MCM10
MCM4
MCM5
MCM7
ORC1
ORC2
ORC4
ORC5
ORC6
TERF2
Entrez ID
4174
23595
HPRD ID
04075
05398
Ensembl ID
ENSG00000100297
ENSG00000135336
Uniprot IDs
B1AHB0
B1AHB1
P33992
Q9UBD5
PDB IDs
Enriched GO Terms of Interacting Partners
?
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
DNA-dependent DNA Replication
DNA Replication Initiation
DNA Replication
Mitotic Cell Cycle Process
Mitotic Cell Cycle
Cell Cycle Process
Cell Cycle
DNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
DNA Strand Elongation Involved In DNA Replication
Cellular Nitrogen Compound Metabolic Process
DNA Strand Elongation
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Nitrogen Compound Metabolic Process
Biosynthetic Process
Regulation Of Cell Cycle Phase Transition
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G2/M Phase Transition
Cellular Response To Stress
Regulation Of Intracellular Transport
Regulation Of Nucleocytoplasmic Transport
Regulation Of Mitotic Cell Cycle Phase Transition
DNA Duplex Unwinding
DNA Geometric Change
Regulation Of Cell Cycle Process
Cellular Metabolic Process
DNA Unwinding Involved In DNA Replication
Regulation Of Phosphorylation
Regulation Of Intracellular Protein Transport
DNA Conformation Change
Regulation Of Phosphorus Metabolic Process
Response To Stress
Cytoplasmic Sequestering Of Transcription Factor
Regulation Of Establishment Of Protein Localization
Cytoplasmic Sequestering Of Protein
Regulation Of Metabolic Process
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Cellular Response To Epidermal Growth Factor Stimulus
Response To Epidermal Growth Factor
Regulation Of Mitotic Cell Cycle
Regulation Of Protein Localization
Regulation Of Protein Import Into Nucleus
Regulation Of Transcription From RNA Polymerase II Promoter
Lipopolysaccharide-mediated Signaling Pathway
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
DNA Replication
DNA Replication Initiation
Mitotic Cell Cycle
DNA Metabolic Process
DNA-dependent DNA Replication
Mitotic Cell Cycle Process
Cell Cycle
Cell Cycle Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
DNA Strand Elongation Involved In DNA Replication
Cellular Macromolecule Biosynthetic Process
DNA Strand Elongation
Macromolecule Biosynthetic Process
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle Phase Transition
Cellular Metabolic Process
DNA Duplex Unwinding
Biosynthetic Process
DNA Geometric Change
Chromosome Organization
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
DNA Conformation Change
Positive Regulation Of Mitotic Cell Cycle
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle Process
Regulation Of Cell Cycle Process
Regulation Of Cell Cycle Phase Transition
Telomere Maintenance
DNA Replication Checkpoint
DNA Unwinding Involved In DNA Replication
Regulation Of Cell Cycle
Positive Regulation Of Cell Cycle
Metabolic Process
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Cell Cycle G1/S Phase Transition
Organelle Organization
Regulation Of Mitotic Cell Cycle
Cell Division
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G2/M Phase Transition
Negative Regulation Of DNA Replication
Cell Cycle Checkpoint
Tagcloud
?
block
cdc45
cdk1
cdk2
cdks
checkpoint
chk1
ddk
delay
detail
differently
excess
exit
hela
hl
initiate
mcm2
mcm3
mcm7
mitotic
obvious
pre
proper
rc
replication
rereplication
s121a
ser
tet
Tagcloud (Difference)
?
block
cdc45
cdk1
cdk2
cdks
checkpoint
chk1
ddk
delay
detail
differently
excess
exit
hela
hl
initiate
mcm2
mcm3
mcm7
mitotic
obvious
pre
proper
rc
replication
rereplication
s121a
ser
tet
Tagcloud (Intersection)
?