MCM5 and MCM3

Number of citations of the paper that reports this interaction (PMID 11248027)
20

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		MCM5	MCM3
Gene Name		minichromosome maintenance complex component 5	minichromosome maintenance complex component 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Membrane MCM Complex	Nucleus Nucleoplasm Alpha DNA Polymerase:primase Complex Centrosome Membrane MCM Complex Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding DNA Helicase Activity Protein Binding ATP Binding	DNA Binding DNA Helicase Activity Protein Binding ATP Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication DNA Duplex Unwinding	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication DNA Duplex Unwinding
Pathways		Synthesis of DNA G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Regulation of DNA replication Activation of the pre-replicative complex Orc1 removal from chromatin S Phase DNA strand elongation Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state Unwinding of DNA	Synthesis of DNA G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Regulation of DNA replication Activation of the pre-replicative complex Orc1 removal from chromatin S Phase DNA strand elongation Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state Unwinding of DNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: APP CDC5L CDC7 CDKN2A KRTAP10-7 MCM2 MCM3 MCM7 MDFI NFKBIA NUDT3 ORC1 ORC2 ORC3 ORC5 ORC6 RBPMS RPA2 STAT1 YWHAG	31 interactors: CCNE1 CDC45 CDC5L CDC6 CDC7 CDK2 CSNK2A1 DBF4 HAUS1 LZTR1 MAPK6 MCM10 MCM2 MCM3AP MCM4 MCM5 MCM6 MCM7 ORC2 ORC4 ORC5 PLK1 POLR2A PPP2R1A PPP2R1B RAD52 RPA2 STAT1 SUPT16H SYF2 YWHAQ
Entrez ID		4174	4172
HPRD ID		04075	04072
Ensembl ID		ENSG00000100297	ENSG00000112118
Uniprot IDs		B1AHB0 B1AHB1 P33992	B4DUQ9 B4DWW4 P25205
PDB IDs
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA-dependent DNA Replication DNA Replication Initiation DNA Replication Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process Cell Cycle DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Strand Elongation Involved In DNA Replication Cellular Nitrogen Compound Metabolic Process DNA Strand Elongation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To Stress Regulation Of Intracellular Transport Regulation Of Nucleocytoplasmic Transport Regulation Of Mitotic Cell Cycle Phase Transition DNA Duplex Unwinding DNA Geometric Change Regulation Of Cell Cycle Process Cellular Metabolic Process DNA Unwinding Involved In DNA Replication Regulation Of Phosphorylation Regulation Of Intracellular Protein Transport DNA Conformation Change Regulation Of Phosphorus Metabolic Process Response To Stress Cytoplasmic Sequestering Of Transcription Factor Regulation Of Establishment Of Protein Localization Cytoplasmic Sequestering Of Protein Regulation Of Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Regulation Of Mitotic Cell Cycle Regulation Of Protein Localization Regulation Of Protein Import Into Nucleus Regulation Of Transcription From RNA Polymerase II Promoter Lipopolysaccharide-mediated Signaling Pathway	Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Replication G1/S Transition Of Mitotic Cell Cycle DNA Replication Initiation Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process Cell Cycle DNA Metabolic Process DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Response To DNA Damage Stimulus DNA Unwinding Involved In DNA Replication DNA Duplex Unwinding DNA Geometric Change Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Cellular Response To Stress Chromosome Organization Cellular Metabolic Process DNA Repair Positive Regulation Of Mitotic Cell Cycle Phase Transition Cell Division Positive Regulation Of Cell Cycle Phase Transition DNA Conformation Change DNA Damage Checkpoint Double-strand Break Repair Via Break-induced Replication Mitotic Cell Cycle Checkpoint Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process DNA Recombinase Assembly Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle
Tagcloud ?		block cdc45 cdk1 cdk2 cdks checkpoint chk1 ddk delay detail differently excess exit hela hl initiate mcm2 mcm3 mcm7 mitotic obvious pre proper rc replication rereplication s121a ser tet	3k499a alanine archaeal atpases cerevisiae electrophoretic exception explanation hairpin hairpins helicase helicases inviability k499a mcm2 mcm7 mini probable ps1 reconstituted replicative saccharomyces sensor severely shaped subtly superfamily unwinding
Tagcloud (Difference) ?		block cdc45 cdk1 cdk2 cdks checkpoint chk1 ddk delay detail differently excess exit hela hl initiate mitotic obvious pre proper rc replication rereplication s121a ser tet	3k499a alanine archaeal atpases cerevisiae electrophoretic exception explanation hairpin hairpins helicase helicases inviability k499a mini probable ps1 reconstituted replicative saccharomyces sensor severely shaped subtly superfamily unwinding
Tagcloud (Intersection) ?		mcm2 mcm3 mcm7