MCM5

Gene Name		minichromosome maintenance complex component 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Membrane MCM Complex
	Molecular Function	DNA Binding DNA Helicase Activity Protein Binding ATP Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication DNA Duplex Unwinding
Pathways		Synthesis of DNA G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Regulation of DNA replication Activation of the pre-replicative complex Orc1 removal from chromatin S Phase DNA strand elongation Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state Unwinding of DNA
Drugs
Diseases
GWAS
Protein-protein Interactions		20 interactors: APP CDC5L CDC7 CDKN2A KRTAP10-7 MCM2 MCM3 MCM7 MDFI NFKBIA NUDT3 ORC1 ORC2 ORC3 ORC5 ORC6 RBPMS RPA2 STAT1 YWHAG
Entrez ID		4174
HPRD ID		04075
Ensembl ID		ENSG00000100297
Uniprot IDs		B1AHB0 B1AHB1 P33992
PDB IDs
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA-dependent DNA Replication DNA Replication Initiation DNA Replication Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process Cell Cycle DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Strand Elongation Involved In DNA Replication Cellular Nitrogen Compound Metabolic Process DNA Strand Elongation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To Stress Regulation Of Intracellular Transport Regulation Of Nucleocytoplasmic Transport Regulation Of Mitotic Cell Cycle Phase Transition DNA Duplex Unwinding DNA Geometric Change Regulation Of Cell Cycle Process Cellular Metabolic Process DNA Unwinding Involved In DNA Replication Regulation Of Phosphorylation Regulation Of Intracellular Protein Transport DNA Conformation Change Regulation Of Phosphorus Metabolic Process Response To Stress Cytoplasmic Sequestering Of Transcription Factor Regulation Of Establishment Of Protein Localization Cytoplasmic Sequestering Of Protein Regulation Of Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Regulation Of Mitotic Cell Cycle Regulation Of Protein Localization Regulation Of Protein Import Into Nucleus Regulation Of Transcription From RNA Polymerase II Promoter Lipopolysaccharide-mediated Signaling Pathway
Tagcloud ?		block cdc45 cdk1 cdk2 cdks checkpoint chk1 ddk delay detail differently excess exit hela hl initiate mcm2 mcm3 mcm7 mitotic obvious pre proper rc replication rereplication s121a ser tet