COL4A6 and OSM

Number of citations of the paper that reports this interaction (PubMedID 25241761)
0

Data Source:
BioGRID (imaging technique)
HPRD (in vitro)

		COL4A6	OSM
Description		collagen type IV alpha 6 chain	oncostatin M
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix	Extracellular Region Extracellular Space
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength	Signaling Receptor Binding Cytokine Activity Oncostatin-M Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Cell Adhesion Extracellular Matrix Organization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Cellular Response To Amino Acid Stimulus	Positive Regulation Of Acute Inflammatory Response Immune Response Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Interleukin-17 Production Positive Regulation Of Peptidyl-serine Phosphorylation Oncostatin-M-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Hormone Secretion Positive Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Hematopoietic Stem Cell Differentiation
Pathways		Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Collagen chain trimerization Attachment of bacteria to epithelial cells	Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions
Drugs
Diseases
GWAS		Electrodermal activity ( 25387706)	Coronary artery disease ( 29212778 33020668) Delirium ( 29631748) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 23128233) Myocardial infarction ( 33532862) Nephropathy ( 21399633) Suicidal ideation ( 30145303) Tonsillectomy ( 27941131)
Interacting Genes		12 interacting genes: APP CD93 DCN FBLN2 FN1 HABP2 MAGEA6 MATN2 MMP9 NOTCH1 OSM SERPINE2	13 interacting genes: APP COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 IL6ST LIFR OSMR S100P TNNT1 ZNF410
Entrez ID		1288	5008
HPRD ID		02364	01300
Ensembl ID		ENSG00000197565	ENSG00000099985
Uniprot IDs		A0A087WZY5 A8MXH5 A8VPY0 B2RTX6 B7ZMM7 F5H3Q5 Q14031	B5MCX1 P13725
PDB IDs			1EVS 8V29 8V2A
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Matrix Glycosaminoglycan Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Peptidase Activator Activity Extracellular Space Regulation Of Cell Migration Regulation Of Locomotion Regulation Of Cell Motility Calcium Ion Binding Regulation Of Development, Heterochronic Positive Regulation Of Astrocyte Differentiation Regulation Of Timing Of Cell Differentiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Extracellular Matrix Structural Constituent Platelet Alpha Granule Signaling Receptor Binding Regulation Of Intracellular Signal Transduction Heparin Binding Negative Regulation Of Transport Extracellular Matrix Binding Regulation Of Astrocyte Differentiation Negative Regulation Of Signaling Negative Regulation Of Cell Communication Endodermal Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Glial Cell Differentiation Amyloid-beta Complex Regulation Of Phosphorus Metabolic Process Growth Cone Lamellipodium Regulation Of Growth Regulation Of Developmental Process Regulation Of Response To Calcium Ion Regulation Of Cell Population Proliferation Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Extracellular Matrix Organization Positive Regulation Of Signal Transduction Dendrite Development Extracellular Structure Organization Regulation Of Cell-substrate Adhesion Positive Regulation Of Neurogenesis Response To Wounding Negative Regulation Of Epithelial Cell Differentiation	Collagen Type IV Trimer Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen-activated Signaling Pathway Collagen Trimer Basement Membrane Extracellular Matrix Structural Constituent Oncostatin-M Receptor Activity Endoplasmic Reticulum Lumen Oncostatin-M-mediated Signaling Pathway Ciliary Neurotrophic Factor Receptor Binding Extracellular Matrix Organization Extracellular Structure Organization Enzyme-linked Receptor Protein Signaling Pathway Extracellular Region Extracellular Matrix Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Complex Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Signaling Pathway Cell Surface Receptor Signaling Pathway Cytokine Binding Growth Factor Binding Ciliary Neurotrophic Factor-mediated Signaling Pathway Cytokine Receptor Activity Receptor Complex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Glomerular Basement Membrane Development Cell Body Transition Metal Ion Binding External Side Of Plasma Membrane Positive Regulation Of Acute Inflammatory Response Integrin Binding Positive Regulation Of Inflammatory Response Signal Transduction Cell Junction Organization Neuromuscular Junction Development Regulation Of Acute Inflammatory Response Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Response To Cytokine Slow-twitch Skeletal Muscle Fiber Contraction Response To Peptide Synapse Organization Regulation Of Cell Population Proliferation Acetylcholine Receptor Activator Activity Lipoprotein Particle
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