COL4A6 and MMP9

Number of citations of the paper that reports this interaction (PMID 9878537)
6

Data Source:
HPRD (in vivo)

		COL4A6	MMP9
Gene Name		collagen, type IV, alpha 6	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Type IV Trimer Endoplasmic Reticulum Lumen	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent	Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Collagen Binding Zinc Ion Binding Identical Protein Binding
	Biological Process	Cell Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process	Skeletal System Development Ossification Proteolysis Axon Guidance Embryo Implantation Extracellular Matrix Disassembly Extracellular Matrix Organization Macrophage Differentiation Collagen Catabolic Process Endodermal Cell Differentiation Positive Regulation Of Apoptotic Process Ephrin Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Keratinocyte Migration Positive Regulation Of Receptor Binding Negative Regulation Of Cation Channel Activity
Pathways		Collagen formation Laminin interactions Collagen degradation ECM proteoglycans Anchoring fibril formation Integrin cell surface interactions Non-integrin membrane-ECM interactions Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures	Signaling by SCF-KIT EPH-ephrin mediated repulsion of cells Axon guidance Collagen formation Collagen degradation Activation of Matrix Metalloproteinases EPH-Ephrin signaling Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs			Marimastat Minocycline Captopril Glucosamine 2-Amino-N,3,3-Trimethylbutanamide 2-{[Formyl(Hydroxy)Amino]Methyl}-4-Methylpentanoic Acid 5-(4-PHENOXYPHENYL)-5-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIMIDINE-2,4,6(2H,3H)-TRIONE (2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDE (3R)-4,4-DIFLUORO-3-[(4-METHOXYPHENYL)SULFONYL]BUTANOIC ACID
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		10 interactors: APP CD93 DCN FBLN2 FN1 HABP2 MATN2 MMP9 OSM SERPINE2	32 interactors: AREG BTC CD44 COL1A1 COL1A2 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 CXCL1 CXCL5 CXCL6 CXCL8 EPHB2 FN1 HAPLN1 KISS1 LCN2 MMP10 MMP26 MMP7 PLG PRSS2 PZP RECK TFPI TGFB1 THBS1 THBS2 TIMP3
Entrez ID		1288	4318
HPRD ID		02364	00387
Ensembl ID		ENSG00000197565	ENSG00000100985
Uniprot IDs		F5H851 Q14031 Q9BS57	P14780
PDB IDs			1GKC 1GKD 1ITV 1L6J 1LKG 2OVX 2OVZ 2OW0 2OW1 2OW2 4H1Q 4H2E 4H3X 4H82 4HMA
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Response To Wounding Extracellular Matrix Disassembly Wound Healing Regulation Of Growth Endodermal Cell Differentiation Nervous System Development Cell Morphogenesis Involved In Differentiation Peptide Cross-linking Anatomical Structure Morphogenesis Mating Generation Of Neurons Endoderm Formation Neurogenesis System Development Platelet Degranulation Seminal Vesicle Epithelium Development Dendrite Regeneration Response To External Stimulus Axon Guidance Negative Regulation Of Transport Regulation Of Peptidase Activity Endoderm Development Blood Coagulation Hemostasis Cell Morphogenesis Negative Regulation Of Ion Transport Response To Abiotic Stimulus Single-organism Behavior Multicellular Organismal Development Mating Plug Formation Synaptic Growth At Neuromuscular Junction Cell Adhesion Anatomical Structure Development Secretion By Cell Immune System Process Response To Stress Axonogenesis Locomotion Collateral Sprouting In Absence Of Injury Tyrosine Phosphorylation Of Stat1 Protein Tyrosine Phosphorylation Of Stat5 Protein Formation Of Primary Germ Layer Axon Development Reproductive Process Regulation Of Body Fluid Levels Dendrite Development Cell Morphogenesis Involved In Neuron Differentiation Behavior	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Locomotion Movement Of Cell Or Subcellular Component Blood Vessel Development Vasculature Development Catabolic Process Regulation Of Body Fluid Levels Response To External Stimulus Chemotaxis Cell Migration Positive Regulation Of Chemotaxis Cell Motility Positive Regulation Of Behavior Immune System Process Regulation Of Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Cellular Response To Organic Substance Negative Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Blood Coagulation Negative Regulation Of Peptidase Activity Inflammatory Response Hemostasis Defense Response Cardiovascular System Development Positive Regulation Of Leukocyte Migration Regulation Of Behavior Platelet Activation Response To Organic Substance Positive Regulation Of Cell Migration Response To Cytokine Positive Regulation Of Cell Motility Response To Stress Positive Regulation Of Cellular Component Movement Negative Regulation Of Proteolysis Positive Regulation Of Locomotion Negative Regulation Of Protein Processing Regulation Of Leukocyte Migration Immune Response Leukocyte Migration Regulation Of Endopeptidase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Cytokine Stimulus Negative Regulation Of Hydrolase Activity
Tagcloud ?		aiming alport ats comprising concepts contiguous deletion deletions distally encompassing epidemiology exon exons extending families hereditary leiomyomatosis ligation mapped multicentric multiplex nephropathy oligo portugal proximally rarely segregated spanning	alkaline alp ccd cleidocranial cocultured ctr ctsk dental dspp dysplasia heterozygous interfered mineralization mineralized mononuclear nodules ocn odontoblast opg osteoblast osteoclast partly pulp rankl remodeling retention runx2 teeth tooth
Tagcloud (Difference) ?		aiming alport ats comprising concepts contiguous deletion deletions distally encompassing epidemiology exon exons extending families hereditary leiomyomatosis ligation mapped multicentric multiplex nephropathy oligo portugal proximally rarely segregated spanning	alkaline alp ccd cleidocranial cocultured ctr ctsk dental dspp dysplasia heterozygous interfered mineralization mineralized mononuclear nodules ocn odontoblast opg osteoblast osteoclast partly pulp rankl remodeling retention runx2 teeth tooth
Tagcloud (Intersection) ?