COL4A6 and SERPINE2

Number of citations of the paper that reports this interaction (PMID 8006028)
4

Data Source:
HPRD (in vivo)

		COL4A6	SERPINE2
Gene Name		collagen, type IV, alpha 6	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Type IV Trimer Endoplasmic Reticulum Lumen	Extracellular Region Extracellular Space Cytosol Extracellular Matrix Platelet Alpha Granule Extrinsic Component Of External Side Of Plasma Membrane Neuromuscular Junction Vesicle
	Molecular Function	Extracellular Matrix Structural Constituent	Serine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Glycosaminoglycan Binding Heparin Binding
	Biological Process	Cell Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process	Blood Coagulation Negative Regulation Of Cell Proliferation Negative Regulation Of Plasminogen Activation Negative Regulation Of Sodium Ion Transport Negative Regulation Of Endopeptidase Activity Negative Regulation Of Protein Processing Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Cerebellar Granular Layer Morphogenesis Negative Regulation Of Blood Coagulation Negative Regulation Of Cell Growth Regulation Of Cell Migration Secretion By Cell Secretory Granule Organization Negative Regulation Of Protein Catabolic Process Mating Plug Formation Negative Regulation Of Proteolysis Negative Regulation Of Smoothened Signaling Pathway Regulation Of Timing Of Cell Differentiation Positive Regulation Of Astrocyte Differentiation Detection Of Mechanical Stimulus Involved In Sensory Perception Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Innervation Seminal Vesicle Epithelium Development Negative Regulation Of Platelet Aggregation
Pathways		Collagen formation Laminin interactions Collagen degradation ECM proteoglycans Anchoring fibril formation Integrin cell surface interactions Non-integrin membrane-ECM interactions Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures	Common Pathway Intrinsic Pathway Dissolution of Fibrin Clot Formation of Fibrin Clot (Clotting Cascade)
Drugs
Diseases
GWAS			Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) ( 23648065) Height ( 20881960)
Protein-Protein Interactions		10 interactors: APP CD93 DCN FBLN2 FN1 HABP2 MATN2 MMP9 OSM SERPINE2	9 interactors: COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 F2 FAM9B PLAU
Entrez ID		1288	5270
HPRD ID		02364	01510
Ensembl ID		ENSG00000197565	ENSG00000135919
Uniprot IDs		F5H851 Q14031 Q9BS57	P07093
PDB IDs			4DY0 4DY7
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Response To Wounding Extracellular Matrix Disassembly Wound Healing Regulation Of Growth Endodermal Cell Differentiation Nervous System Development Cell Morphogenesis Involved In Differentiation Peptide Cross-linking Anatomical Structure Morphogenesis Mating Generation Of Neurons Endoderm Formation Neurogenesis System Development Platelet Degranulation Seminal Vesicle Epithelium Development Dendrite Regeneration Response To External Stimulus Axon Guidance Negative Regulation Of Transport Regulation Of Peptidase Activity Endoderm Development Blood Coagulation Hemostasis Cell Morphogenesis Negative Regulation Of Ion Transport Response To Abiotic Stimulus Single-organism Behavior Multicellular Organismal Development Mating Plug Formation Synaptic Growth At Neuromuscular Junction Cell Adhesion Anatomical Structure Development Secretion By Cell Immune System Process Response To Stress Axonogenesis Locomotion Collateral Sprouting In Absence Of Injury Tyrosine Phosphorylation Of Stat1 Protein Tyrosine Phosphorylation Of Stat5 Protein Formation Of Primary Germ Layer Axon Development Reproductive Process Regulation Of Body Fluid Levels Dendrite Development Cell Morphogenesis Involved In Neuron Differentiation Behavior	Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Chemotaxis Locomotion Movement Of Cell Or Subcellular Component Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Generation Of Neurons Neuron Projection Development Cell Projection Morphogenesis Neurogenesis Cell Part Morphogenesis Catabolic Process Response To External Stimulus Neuron Development Cell Morphogenesis Glomerular Basement Membrane Development Neuron Differentiation Cell Projection Organization Nervous System Development Fibrinolysis Cell Development Neuromuscular Junction Development Renal System Development Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Glomerulus Development Cell Differentiation Negative Regulation Of Wound Healing Urogenital System Development Negative Regulation Of Angiogenesis Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Blood Coagulation System Development Regulation Of Wound Healing Endothelial Cell Apoptotic Process Regulation Of Smooth Muscle Cell-matrix Adhesion Nephron Development Multicellular Organismal Development Synapse Organization
Tagcloud ?		aiming alport ats comprising concepts contiguous deletion deletions distally encompassing epidemiology exon exons extending families hereditary leiomyomatosis ligation mapped multicentric multiplex nephropathy oligo portugal proximally rarely segregated spanning	adulthood alters antagonize cerebellar cerebellum cgnp cgnps enlarged enlargement exit gli1 granular hedgehog interferes lobes lrps mitogenic morphogens nexin outer overactivation pn protease relies shaping shh sonic tight
Tagcloud (Difference) ?		aiming alport ats comprising concepts contiguous deletion deletions distally encompassing epidemiology exon exons extending families hereditary leiomyomatosis ligation mapped multicentric multiplex nephropathy oligo portugal proximally rarely segregated spanning	adulthood alters antagonize cerebellar cerebellum cgnp cgnps enlarged enlargement exit gli1 granular hedgehog interferes lobes lrps mitogenic morphogens nexin outer overactivation pn protease relies shaping shh sonic tight
Tagcloud (Intersection) ?