COL4A6 and HABP2

Number of citations of the paper that reports this interaction (PubMedID 1724753)
0

Data Source:
HPRD (in vivo)

		COL4A6	HABP2
Description		collagen type IV alpha 6 chain	hyaluronan binding protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix	Extracellular Region Extracellular Space
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength	Serine-type Endopeptidase Activity Calcium Ion Binding Glycosaminoglycan Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Cell Adhesion Extracellular Matrix Organization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Cellular Response To Amino Acid Stimulus	Proteolysis Cell Adhesion
Pathways		Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Collagen chain trimerization Attachment of bacteria to epithelial cells
Drugs			Hyaluronic acid
Diseases
GWAS		Electrodermal activity ( 25387706)	Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Cardiac troponin-I levels ( 31014085) Central corneal thickness ( 29760442 32528159) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 27863252 32888494) Heel bone mineral density ( 28869591) Ischemic stroke ( 26732560) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Plasma factor VII activating protease levels ( 30070759) Urate levels ( 31578528) Waist-to-hip ratio adjusted for body mass index ( 28430825)
Interacting Genes		12 interacting genes: APP CD93 DCN FBLN2 FN1 HABP2 MAGEA6 MATN2 MMP9 NOTCH1 OSM SERPINE2	7 interacting genes: COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 KNG1
Entrez ID		1288	3026
HPRD ID		02364	04890
Ensembl ID		ENSG00000197565	ENSG00000148702
Uniprot IDs		A0A087WZY5 A8MXH5 A8VPY0 B2RTX6 B7ZMM7 F5H3Q5 Q14031	Q14520
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Matrix Glycosaminoglycan Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Peptidase Activator Activity Extracellular Space Regulation Of Cell Migration Regulation Of Locomotion Regulation Of Cell Motility Calcium Ion Binding Regulation Of Development, Heterochronic Positive Regulation Of Astrocyte Differentiation Regulation Of Timing Of Cell Differentiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Extracellular Matrix Structural Constituent Platelet Alpha Granule Signaling Receptor Binding Regulation Of Intracellular Signal Transduction Heparin Binding Negative Regulation Of Transport Extracellular Matrix Binding Regulation Of Astrocyte Differentiation Negative Regulation Of Signaling Negative Regulation Of Cell Communication Endodermal Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Glial Cell Differentiation Amyloid-beta Complex Regulation Of Phosphorus Metabolic Process Growth Cone Lamellipodium Regulation Of Growth Regulation Of Developmental Process Regulation Of Response To Calcium Ion Regulation Of Cell Population Proliferation Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Extracellular Matrix Organization Positive Regulation Of Signal Transduction Dendrite Development Extracellular Structure Organization Regulation Of Cell-substrate Adhesion Positive Regulation Of Neurogenesis Response To Wounding Negative Regulation Of Epithelial Cell Differentiation	Collagen Type IV Trimer Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen-activated Signaling Pathway Collagen Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix Structural Constituent Extracellular Matrix Extracellular Structure Organization Extracellular Matrix Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Extracellular Region Enzyme-linked Receptor Protein Signaling Pathway Glomerular Basement Membrane Development Neuromuscular Junction Development Cell Surface Receptor Signaling Pathway Cellular Response To Amino Acid Stimulus Response To Amino Acid Signal Transduction Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Retinal Blood Vessel Morphogenesis Molecular Adaptor Activity Synapse Organization Platelet-derived Growth Factor Binding Retina Vasculature Morphogenesis In Camera-type Eye Endothelial Cell Apoptotic Process Negative Regulation Of Vascular Endothelial Cell Proliferation Metalloendopeptidase Inhibitor Activity Angiogenesis Renal Tubule Morphogenesis Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Multicellular Organismal Process
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