CXXC5 and RSPH1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		CXXC5	RSPH1
Description		CXXC finger protein 5	radial spoke head component 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Condensed Nuclear Chromosome Outer Dense Fiber Radial Spoke Radial Spoke Head Nucleus Chromosome Cytoplasm Cytosol Cytoskeleton Cilium Axoneme Motile Cilium Sperm Flagellum Cell Projection Meiotic Spindle 9+2 Motile Cilium Radial Spoke Head 1 Radial Spoke Head 3
	Molecular Function	DNA Binding Zinc Ion Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding DNA-binding Transcription Factor Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Generation Of Precursor Metabolites And Energy	Microtubule-based Process Spermatid Development Axoneme Assembly Meiotic Cell Cycle
Pathways		Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Adult body size ( 32376654) Appendicular lean mass ( 33097823) Body mass index ( 25673413) Hip circumference adjusted for BMI ( 34021172) Ovarian cancer ( 30557369) Refractive error ( 32231278)
Interacting Genes		14 interacting genes: ATM DSCAM DSCR9 HUNK KCNJ6 RCAN1 RSPH1 SKIL SMAD3 SMAD5 SMAD7 SMAD9 UBASH3A VDR	125 interacting genes: ABCA2 AGTPBP1 APPL1 ASCL1 B4GALT3 BTBD1 BTG3 CADM1 CASK CCN2 CFH CLSTN3 CLU CMAS CNPPD1 COG4 CORO1C CORO2A CORO2B CREBZF CRMP1 CTSL CTTN CXXC5 DCTN6 DEF8 DNAJC7 DNER DOCK3 DST EDIL3 EEF2 EIF3D EZR FAIM FLOT1 FN1 FRMD4B GAMT GLS GLUL HIVEP2 JPH1 JPH3 KDM4A KDM6A KIF1A KIF1B LGI3 LONRF1 MAPK8IP1 MAPK8IP2 MBD4 MEG3 MFGE8 MIA2 MKRN3 MORN2 MORN3 MTMR2 MYCBP2 NCAM2 NELL1 NETO1 NF2 NFKBID NHP2 NPRL2 NRCAM OAT OBSL1 OSBPL1A PARP1 PAX6 PDE4DIP PLEC PNMA2 POGZ POLR2C PTPRD RARB RELN RHOG RNF10 SDHA SEPTIN3 SEZ6L SF1 SF3B1 SH3GLB2 SMARCE1 SNRNP70 SOX10 SRXN1 TF TOLLIP TRIM33 TRIM52 TUBA1B TUBB TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B UAP1L1 UBA7 UBC USP11 USP7 USP9X USP9Y WBP11 WDR13 WDR17 ZBTB38 ZBTB44 ZBTB5 ZNF197 ZNF251 ZNF34 ZNF512B ZNF662 ZNF785 ZNF793
Entrez ID		51523	89765
HPRD ID		13105	11651
Ensembl ID		ENSG00000171604	ENSG00000160188
Uniprot IDs		Q7LFL8	Q8WYR4
PDB IDs		5W9S	8J07
Enriched GO Terms of Interacting Partners?		Heteromeric SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction SMAD Protein Complex Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transcription Regulator Complex Intracellular Signal Transduction Response To Growth Factor Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Cellular Developmental Process Tissue Development DEAD/H-box RNA Helicase Binding Kidney Epithelium Development Positive Regulation Of Cell Differentiation Cellular Response To Growth Factor Stimulus Lens Fiber Cell Differentiation Regulation Of Cell Differentiation Regulation Of Ossification Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Osteoblast Differentiation Striated Muscle Tissue Development Muscle Tissue Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cartilage Development Signal Transduction Positive Regulation Of Developmental Process Cell-cell Junction Organization Cell Junction Organization Intracellular Signaling Cassette Germ Cell Development Cell Development Developmental Process Involved In Reproduction Negative Regulation Of Signal Transduction Positive Regulation Of Bone Mineralization Negative Regulation Of Ossification Somitogenesis Negative Regulation Of Signaling Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Communication Anatomical Structure Morphogenesis Negative Regulation Of Transcription By RNA Polymerase II Tube Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Lung Blood Pressure Positive Regulation Of Biomineral Tissue Development	Microtubule Cytoskeleton Structural Constituent Of Cytoskeleton Co-SMAD Binding Cytoskeleton Cell Periphery Neuron Migration Cell-substrate Junction Organization Cell-substrate Junction Assembly Retrograde Axonal Transport Negative Regulation Of Schwann Cell Proliferation Microtubule Cytoskeleton Organization Nucleus Positive Regulation Of Early Endosome To Late Endosome Transport Axon Intercellular Bridge Microtubule-based Process Mitotic Cell Cycle Regulation Of Nervous System Development Axon Cytoplasm Axonal Transport GTPase Activity Regulation Of Cell Projection Organization Cell Junction Organization Microtubule Regulation Of Plasma Membrane Bounded Cell Projection Organization Cytoskeleton Organization Oligodendrocyte Cell Fate Specification Anterograde Axonal Transport Chromaffin Granule Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Glial Cell Proliferation Regulation Of Nervous System Process Regulation Of Myelination GTP Binding Axo-dendritic Transport Regulation Of Synapse Organization Cerebral Cortex Development Regulation Of Cell Morphogenesis Synapse Modulation Of Excitatory Postsynaptic Potential Retrograde Neuronal Dense Core Vesicle Transport Mitotic Spindle Positive Regulation Of Cell Differentiation Regulation Of Postsynapse Organization Cell Motility Dendrite Cytoskeleton-dependent Intracellular Transport Regulation Of Cellular Component Organization Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Hemidesmosome Assembly
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