ARRB2 and LIMK1

Number of citations of the paper that reports this interaction (PMID 17500066)
38

Data Source:
BioGRID (pull down, affinity chromatography technology)

		ARRB2	LIMK1
Gene Name		arrestin, beta 2	LIM domain kinase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Coated Pit Postsynaptic Density Basolateral Plasma Membrane Endocytic Vesicle Cytoplasmic Vesicle Dendritic Spine Postsynaptic Membrane	Nucleoplasm Cytoplasm Cytosol Focal Adhesion Neuron Projection
	Molecular Function	G-protein Coupled Receptor Binding Receptor Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Alpha-1A Adrenergic Receptor Binding Alpha-1B Adrenergic Receptor Binding Angiotensin Receptor Binding Type 1 Angiotensin Receptor Binding D1 Dopamine Receptor Binding Follicle-stimulating Hormone Receptor Binding Type 2A Serotonin Receptor Binding Protein Complex Binding Protein Complex Scaffold Protein Kinase B Binding Mitogen-activated Protein Kinase Binding 14-3-3 Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Heat Shock Protein Binding Protein Heterodimerization Activity
	Biological Process	G-protein Coupled Receptor Internalization Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Positive Regulation Of Receptor Internalization Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Brain Development Blood Coagulation Adult Walking Behavior Protein Transport Protein Ubiquitination Platelet Activation Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Receptor Internalization Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of GTPase Activity Negative Regulation Of Smooth Muscle Cell Apoptotic Process Follicle-stimulating Hormone Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Peptidyl-tyrosine Phosphorylation Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Calcium Ion Transport Cell Chemotaxis Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of DNA Biosynthetic Process	Protein Phosphorylation Signal Transduction Rho Protein Signal Transduction Nervous System Development Axon Guidance Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Bundle Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Positive Regulation Of Axon Extension Ephrin Receptor Signaling Pathway Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Stress Fiber Assembly
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by Wnt beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Hedgehog 'on' state Signaling by NOTCH1 WNT5A-dependent internalization of FZD4 Signaling by Hedgehog Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Platelet activation, signaling and aggregation PCP/CE pathway Activation of SMO FBXW7 Mutants and NOTCH1 in Cancer	EPHB-mediated forward signaling Axon guidance Semaphorin interactions EPH-Ephrin signaling Sema3A PAK dependent Axon repulsion Sema4D in semaphorin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Sema4D induced cell migration and growth-cone collapse Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		47 interactors: ADRB2 AGTR1 AP1B1 AP2M1 ARF6 AVPR2 C5AR1 CDC42 CLTC CSNK2A1 CSNK2A2 CXCR4 CYTH2 DVL2 FLNA FZD4 HCRTR1 HIPK3 HTR2C ITCH LHCGR LIMK1 MAP2K4 MAP3K5 MAPK1 MAPK10 MAPK9 MDM2 MED8 NDUFS7 NFKBIA NTS NTSR1 OPRD1 OXTR PARK2 PDE4D PTAFR PTGDS RAF1 RALGDS SLC9A5 SMARCC2 STC2 TGFBR3 TRH USP33	25 interactors: ABCA1 APP ARRB1 ARRB2 BMPR2 CDC42BPA CDKN1C CFL1 CFL2 HIST1H1A LATS1 LIMK2 MAPK14 MAPKAPK2 MBP NRG1 PAK1 PAK2 PAK4 PXN RLIM ROCK1 SRPK1 SSH3 YWHAZ
Entrez ID		409	3984
HPRD ID		00147	03210
Ensembl ID		ENSG00000141480	ENSG00000106683
Uniprot IDs		K7ENA6 P32121 Q59EM5	P53667
PDB IDs			3S95
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Signaling Signal Transduction Regulation Of Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Response To External Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Stress-activated MAPK Cascade Immune Response-regulating Signaling Pathway Intracellular Signal Transduction Cellular Response To Organic Substance Response To Stimulus Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of JNK Cascade Response To Organic Substance Positive Regulation Of MAPK Cascade Regulation Of Protein Phosphorylation Chemotaxis Positive Regulation Of Protein Modification Process Regulation Of Catalytic Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Phosphorylation Locomotion Immune System Process Regulation Of Metabolic Process Regulation Of Cellular Process Positive Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Fc Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Apoptotic Process Response To Stress Positive Regulation Of Cellular Metabolic Process Programmed Cell Death Regulation Of MAP Kinase Activity Response To Lipid	Phosphorylation Cellular Protein Modification Process Protein Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Phosphate-containing Compound Metabolic Process Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Cellular Protein Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Signal Transduction By Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Protein Metabolic Process Platelet Activation Signaling Regulation Of Kinase Activity Cell Communication Response To External Stimulus Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Wound Healing Regulation Of Cellular Amino Acid Metabolic Process Signal Transduction Cell Differentiation Generation Of Neurons Regulation Of Cellular Protein Metabolic Process Response To Stress Regulation Of Organelle Organization Locomotion Immune Response Neurogenesis Apoptotic Process Response To Wounding Positive Regulation Of Cellular Metabolic Process Anatomical Structure Development Regulation Of Signaling Defense Response Programmed Cell Death Organelle Organization Immune System Process Regulation Of Protein Metabolic Process
Tagcloud ?		17p13 22q11 adrbk2 adrenergic ark ark1 ark2 arrestin assignment band chromosome coding cofactor coupled desensitization grk4 grk5 grk6 includes it11 mapped mapping multigene occupied phosphorylates q37 refine rhodopsin sag	alkaloid cdk4 changing chemoresistance cofilin cytotoxic decreasing detecting egfr egfrp erk1 explored extracted flavescens gastric herb invasion matrine mek mmp2 oxide oxymatrine phospho quinolizidine root ser3 sophora thr508 tyr845
Tagcloud (Difference) ?		17p13 22q11 adrbk2 adrenergic ark ark1 ark2 arrestin assignment band chromosome coding cofactor coupled desensitization grk4 grk5 grk6 includes it11 mapped mapping multigene occupied phosphorylates q37 refine rhodopsin sag	alkaloid cdk4 changing chemoresistance cofilin cytotoxic decreasing detecting egfr egfrp erk1 explored extracted flavescens gastric herb invasion matrine mek mmp2 oxide oxymatrine phospho quinolizidine root ser3 sophora thr508 tyr845
Tagcloud (Intersection) ?