ARRB2 and MAP2K4

Number of citations of the paper that reports this interaction (PMID 11090355)
131

Data Source:
BioGRID (affinity chromatography technology, unspecified method)

		ARRB2	MAP2K4
Gene Name		arrestin, beta 2	mitogen-activated protein kinase kinase 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Coated Pit Postsynaptic Density Basolateral Plasma Membrane Endocytic Vesicle Cytoplasmic Vesicle Dendritic Spine Postsynaptic Membrane	Intracellular Nucleus Cytosol Axon Dendrite Cytoplasm Perikaryon
	Molecular Function	G-protein Coupled Receptor Binding Receptor Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Alpha-1A Adrenergic Receptor Binding Alpha-1B Adrenergic Receptor Binding Angiotensin Receptor Binding Type 1 Angiotensin Receptor Binding D1 Dopamine Receptor Binding Follicle-stimulating Hormone Receptor Binding Type 2A Serotonin Receptor Binding Protein Complex Binding Protein Complex Scaffold Protein Kinase B Binding Mitogen-activated Protein Kinase Binding 14-3-3 Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding
	Biological Process	G-protein Coupled Receptor Internalization Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Positive Regulation Of Receptor Internalization Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Brain Development Blood Coagulation Adult Walking Behavior Protein Transport Protein Ubiquitination Platelet Activation Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Receptor Internalization Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of GTPase Activity Negative Regulation Of Smooth Muscle Cell Apoptotic Process Follicle-stimulating Hormone Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Peptidyl-tyrosine Phosphorylation Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Calcium Ion Transport Cell Chemotaxis Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of DNA Biosynthetic Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Signal Transduction JNK Cascade Activation Of JUN Kinase Activity Pathogenesis Peptidyl-tyrosine Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Innate Immune Response Positive Regulation Of DNA Replication Stress-activated MAPK Cascade Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Mechanical Stimulus Cellular Response To Sorbitol
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by Wnt beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Hedgehog 'on' state Signaling by NOTCH1 WNT5A-dependent internalization of FZD4 Signaling by Hedgehog Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Platelet activation, signaling and aggregation PCP/CE pathway Activation of SMO FBXW7 Mutants and NOTCH1 in Cancer	Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence FCERI mediated MAPK activation Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Uptake and actions of bacterial toxins MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Uptake and function of anthrax toxins Innate Immune System JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Oxidative Stress Induced Senescence Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling
Drugs
Diseases
GWAS			Response to amphetamines ( 22952603)
Protein-Protein Interactions		47 interactors: ADRB2 AGTR1 AP1B1 AP2M1 ARF6 AVPR2 C5AR1 CDC42 CLTC CSNK2A1 CSNK2A2 CXCR4 CYTH2 DVL2 FLNA FZD4 HCRTR1 HIPK3 HTR2C ITCH LHCGR LIMK1 MAP2K4 MAP3K5 MAPK1 MAPK10 MAPK9 MDM2 MED8 NDUFS7 NFKBIA NTS NTSR1 OPRD1 OXTR PARK2 PDE4D PTAFR PTGDS RAF1 RALGDS SLC9A5 SMARCC2 STC2 TGFBR3 TRH USP33	37 interactors: AKT1 APP ARRB1 ARRB2 CFLAR DUSP22 EFNA4 FLNA FLNC GEMIN5 ITCH JUN LRRK2 MAP2K6 MAP3K1 MAP3K10 MAP3K11 MAP3K12 MAP3K14 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K7 MAP3K8 MAP4K2 MAPK1 MAPK10 MAPK12 MAPK14 MAPK8 MAPK8IP3 MAPK9 RBBP8 SPAG9 TRIB1 ZAK
Entrez ID		409	6416
HPRD ID		00147	03213
Ensembl ID		ENSG00000141480	ENSG00000065559
Uniprot IDs		K7ENA6 P32121 Q59EM5	B7ZA62 P45985
PDB IDs			3ALN 3ALO 3VUT
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Signaling Signal Transduction Regulation Of Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Response To External Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Stress-activated MAPK Cascade Immune Response-regulating Signaling Pathway Intracellular Signal Transduction Cellular Response To Organic Substance Response To Stimulus Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of JNK Cascade Response To Organic Substance Positive Regulation Of MAPK Cascade Regulation Of Protein Phosphorylation Chemotaxis Positive Regulation Of Protein Modification Process Regulation Of Catalytic Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Phosphorylation Locomotion Immune System Process Regulation Of Metabolic Process Regulation Of Cellular Process Positive Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Fc Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Apoptotic Process Response To Stress Positive Regulation Of Cellular Metabolic Process Programmed Cell Death Regulation Of MAP Kinase Activity Response To Lipid	MAPK Cascade Signal Transduction By Phosphorylation Regulation Of MAPK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of MAPK Cascade Activation Of MAPK Activity Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Activation Of Protein Kinase Activity Regulation Of MAP Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process JNK Cascade Positive Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Activation Of MAPKK Activity Positive Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of MAP Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Kinase Activity Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Modification Process Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Regulation Of Signal Transduction Phosphorylation Regulation Of Signaling Regulation Of JNK Cascade Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Intracellular Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Phosphate-containing Compound Metabolic Process Positive Regulation Of JUN Kinase Activity Cell Death Death Positive Regulation Of JNK Cascade Regulation Of JUN Kinase Activity
Tagcloud ?		17p13 22q11 adrbk2 adrenergic ark ark1 ark2 arrestin assignment band chromosome coding cofactor coupled desensitization grk4 grk5 grk6 includes it11 mapped mapping multigene occupied phosphorylates q37 refine rhodopsin sag	aurka aurkb bioinformatics cdkn2a copy custom describing epha5 flt4 frameshift insertions interrogating kdm6a leiomyosarcomas locally losses multiplexed nf1 ngs notch1 pdgfrb pik3ca pipeline rationale rb1 sarcomas soft stratification targetable
Tagcloud (Difference) ?		17p13 22q11 adrbk2 adrenergic ark ark1 ark2 arrestin assignment band chromosome coding cofactor coupled desensitization grk4 grk5 grk6 includes it11 mapped mapping multigene occupied phosphorylates q37 refine rhodopsin sag	aurka aurkb bioinformatics cdkn2a copy custom describing epha5 flt4 frameshift insertions interrogating kdm6a leiomyosarcomas locally losses multiplexed nf1 ngs notch1 pdgfrb pik3ca pipeline rationale rb1 sarcomas soft stratification targetable
Tagcloud (Intersection) ?