ARRB2 and DLG4

Number of citations of the paper that reports this interaction (PubMedID 26898829)
0

Data Source:
BioGRID (fluorescent resonance energy transfer)

		ARRB2	DLG4
Description		arrestin beta 2	discs large MAGUK scaffold protein 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane Endocytic Vesicle Endocytic Vesicle Membrane Cytoplasmic Vesicle Postsynapse Glutamatergic Synapse	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Adherens Junction Synaptic Vesicle Voltage-gated Potassium Channel Complex Postsynaptic Density Membrane Cell Junction Axon Dendrite Endocytic Vesicle Membrane Cortical Cytoskeleton Neuromuscular Junction AMPA Glutamate Receptor Complex Dendrite Cytoplasm Cell Projection Neuron Projection Dendritic Spine Organelle Juxtaparanode Region Of Axon Cerebellar Mossy Fiber Neuron Projection Terminus Neuron Spine Synapse Postsynaptic Membrane Excitatory Synapse Cell Periphery Synaptic Membrane Presynapse Postsynapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	G Protein-coupled Receptor Binding Signaling Receptor Binding Protein Binding Enzyme Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Angiotensin Receptor Binding D1 Dopamine Receptor Binding Protein Kinase B Binding Molecular Adaptor Activity	Protein Binding Kinase Binding Protein Kinase Binding Protein Phosphatase Binding PDZ Domain Binding Protein-macromolecule Adaptor Activity Beta-1 Adrenergic Receptor Binding D1 Dopamine Receptor Binding P2Y1 Nucleotide Receptor Binding Acetylcholine Receptor Binding Ionotropic Glutamate Receptor Binding Protein-containing Complex Binding Neuroligin Family Protein Binding Scaffold Protein Binding
	Biological Process	Desensitization Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Internalization Positive Regulation Of Receptor Internalization Transcription By RNA Polymerase II Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Adult Walking Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Protein Transport Protein Ubiquitination Sensory Perception Of Pain Negative Regulation Of Protein Ubiquitination Receptor Internalization Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Modulation Of Chemical Synaptic Transmission Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Excitatory Postsynaptic Potential Cell Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Postsynaptic Signal Transduction Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cardiac Muscle Cell Differentiation	Negative Regulation Of Receptor Internalization Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Nervous System Development Learning Synaptic Vesicle Maturation Social Behavior Protein Localization To Synapse Locomotory Exploration Behavior Cellular Response To Potassium Ion Establishment Of Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Synaptic Transmission Neuromuscular Process Controlling Balance Dendritic Spine Morphogenesis Protein-containing Complex Assembly Vocalization Behavior AMPA Glutamate Receptor Clustering Receptor Localization To Synapse Cell-cell Adhesion NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Grooming Behavior
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus G alpha (s) signalling events Thrombin signalling through proteinase activated receptors (PARs) WNT5A-dependent internalization of FZD4 Activation of SMO Activation of SMO MAP2K and MAPK activation Ub-specific processing proteases Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Signaling downstream of RAS mutants Signaling by RAF1 mutants TGFBR3 regulates TGF-beta signaling	Signaling by ERBB4 Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RHO GTPases activate CIT RAF/MAP kinase cascade LGI-ADAM interactions Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs			Guanidine Guanosine-5'-Monophosphate
Diseases
GWAS		Behcet's disease ( 33393726) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) White blood cell count ( 32888494)	Cholesterol, total ( 24097068 25961943) Hematocrit ( 32888494) Hemoglobin ( 32888494) LDL cholesterol ( 24097068 25961943) LDL cholesterol levels ( 28334899) Liver enzyme levels (alkaline phosphatase) ( 22001757 33972514) Serum alkaline phosphatase levels ( 29403010 33547301)
Interacting Genes		60 interacting genes: ADRB2 AGTR1 AGTR2 AP1B1 AP2M1 ARF6 AVPR2 BCAS1 C5AR1 CDC42 CLTC CRHR1 CSNK2A1 CSNK2A2 CXCR4 CYTH2 DLG4 DVL2 EGFR EIF2AK4 FLNA FZD4 HCRTR1 HIPK3 HTR2C ITCH LHCGR LIMK1 MAP2K4 MAP3K5 MAPK1 MAPK10 MAPK9 MAS1 MDM2 MED8 NDUFS7 NEDD4L NFKBIA NTS NTSR1 OPRD1 OXER1 OXTR PDE4D PTAFR PTGDS RAF1 RALGDS RHO SLC9A5 SMARCC2 SNCA STC2 SUMO1 SUMO2 TGFBR3 TRH UBC UBE2I	139 interacting genes: ABHD17A ACTN2 ADGRB1 ADGRB2 ADGRL1 ADRB1 AKAP5 ARHGAP32 ARRB2 ASIC3 ATP2B2 ATP2B4 BEGAIN CACNG2 CASK CD46 CIT CLU CNKSR2 CRHR1 CRIPT CYLD DLG2 DLG3 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DRD1 DSCAM DYNLL1 EEF1G EFNB2 ERBB2 ERBB4 ERBIN EXOC4 FTH1 FYN FZD1 FZD2 FZD4 FZD7 GDA GLS2 GNG13 GOLGA2 GPSM2 GRIK1 GRIK2 GRIK5 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A GRIN3B GUCY1A2 HGS HNRNPC HTR2A HTR2C HTT IL13RA1 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCND2 KCNJ10 KCNJ12 KCNJ2 KCNJ4 KHDRBS1 KIF13B KIF1B LIN7A LIN7B LRFN1 LRP1 LRP2 LRP8 LRRC1 LYN LZTS2 MAP1A MAP3K10 MAPK12 MDM2 MPND MPP1 MT-CO1 NCKIPSD NDOR1 NLGN1 NLGN2 NLGN3 NLGN4X NOMO1 NOS1 PCDH10 PCMT1 PEX19 PICK1 PRKCA PRR16 PTK2B PTPRG RALBP1 RASSF4 RPS6KA1 SCN5A SEMA4B SEMA4C SEMA4F SEMA4G SHANK1 SHANK2 SIPA1L1 SLC4A7 SPRR2A SRC SYNGAP1 TAMALIN TANC1 THOC3 TIAM1 TJAP1 TRAF6 TUBB2B UBE3A VANGL2 VMAC WDR74 WNT3A YES1 ZDHHC17
Entrez ID		409	1742
HPRD ID		00147	04199
Ensembl ID		ENSG00000141480	ENSG00000132535
Uniprot IDs		K7ENA6 P32121 Q59EM5 Q68DZ5	A0A3B3IS17 B7Z4H2 B7Z647 B9EGL1 P78352
PDB IDs			1KEF 2MES 3I4W 3K82 3ZRT 5J7J 5JXB 6QJD 6QJF 6QJG 6QJI 6QJJ 6QJK 6QJL 6QJN 6SPV 6SPZ 8AH4 8AH5 8AH6 8AH7 8AH8
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Plasma Membrane Signal Transduction Regulation Of Biological Quality Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Regulation Of Multicellular Organismal Process Protein Serine Kinase Activity Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Intracellular Signal Transduction Protein Serine/threonine Kinase Activity Protein Kinase Activity Clathrin-coated Endocytic Vesicle Membrane Angiotensin Type II Receptor Activity Regulation Of Transport Positive Regulation Of Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Metal Ion Transport Regulation Of MAPK Cascade Regulation Of System Process Regulation Of Systemic Arterial Blood Pressure Glutamatergic Synapse Regulation Of Developmental Process Positive Regulation Of Locomotion Negative Regulation Of Systemic Arterial Blood Pressure Ubiquitin Protein Ligase Binding Enzyme Binding Blood Vessel Diameter Maintenance Regulation Of Tube Size Kinase Activity Import Into Cell Postsynapse Regulation Of Monoatomic Ion Transport Response To Stress Regulation Of Blood Pressure Neuron Spine Positive Regulation Of Neuron Projection Arborization Endocytosis Positive Regulation Of Cell Migration	Synapse Glutamatergic Synapse Postsynaptic Density Membrane Plasma Membrane Postsynaptic Membrane Modulation Of Chemical Synaptic Transmission Postsynaptic Density Regulation Of Membrane Potential Regulation Of Biological Quality Ionotropic Glutamate Receptor Signaling Pathway Membrane Regulation Of Signaling Regulation Of Cell Communication Scaffold Protein Binding Synaptic Signaling Chemical Synaptic Transmission Dendrite Regulation Of Synapse Organization Trans-synaptic Signaling Glutamate Receptor Signaling Pathway Regulation Of Postsynaptic Membrane Potential Signaling Ligand-gated Ion Channel Signaling Pathway Metal Ion Transport Cell Communication Presynaptic Membrane NMDA Selective Glutamate Receptor Complex PDZ Domain Binding Monoatomic Cation Transport Monoatomic Ion Transport Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Synaptic Transmission, Glutamatergic Regulation Of System Process Cell-cell Signaling NMDA Glutamate Receptor Activity Modulation Of Excitatory Postsynaptic Potential Regulation Of Synaptic Plasticity Dendritic Spine Signal Transduction Monoatomic Ion Channel Activity Protein Localization To Synapse Synaptic Transmission, Glutamatergic Positive Regulation Of Excitatory Postsynaptic Potential Ligand-gated Monoatomic Ion Channel Activity Monoatomic Ion Channel Complex Regulation Of Transport Cell Surface Receptor Signaling Pathway Regulation Of Monoatomic Ion Transmembrane Transport Monoatomic Ion Transmembrane Transport Regulation Of Synapse Assembly
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