ARRB2 and AP1B1

Number of citations of the paper that reports this interaction (PMID 10097102)
113

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		ARRB2	AP1B1
Gene Name		arrestin, beta 2	adaptor-related protein complex 1, beta 1 subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Coated Pit Postsynaptic Density Basolateral Plasma Membrane Endocytic Vesicle Cytoplasmic Vesicle Dendritic Spine Postsynaptic Membrane	Golgi Membrane Lysosomal Membrane Cytosol Clathrin Adaptor Complex Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane
	Molecular Function	G-protein Coupled Receptor Binding Receptor Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Alpha-1A Adrenergic Receptor Binding Alpha-1B Adrenergic Receptor Binding Angiotensin Receptor Binding Type 1 Angiotensin Receptor Binding D1 Dopamine Receptor Binding Follicle-stimulating Hormone Receptor Binding Type 2A Serotonin Receptor Binding Protein Complex Binding Protein Complex Scaffold Protein Kinase B Binding Mitogen-activated Protein Kinase Binding 14-3-3 Protein Binding	Transporter Activity Protein Binding Protein Transporter Activity Protein Kinase Binding
	Biological Process	G-protein Coupled Receptor Internalization Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Positive Regulation Of Receptor Internalization Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Brain Development Blood Coagulation Adult Walking Behavior Protein Transport Protein Ubiquitination Platelet Activation Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Receptor Internalization Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of GTPase Activity Negative Regulation Of Smooth Muscle Cell Apoptotic Process Follicle-stimulating Hormone Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Peptidyl-tyrosine Phosphorylation Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Calcium Ion Transport Cell Chemotaxis Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of DNA Biosynthetic Process	Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Defense Response To Virus By Virus Membrane Organization
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by Wnt beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Hedgehog 'on' state Signaling by NOTCH1 WNT5A-dependent internalization of FZD4 Signaling by Hedgehog Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Platelet activation, signaling and aggregation PCP/CE pathway Activation of SMO FBXW7 Mutants and NOTCH1 in Cancer	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Golgi Associated Vesicle Biogenesis The role of Nef in HIV-1 replication and disease pathogenesis Nef mediated downregulation of MHC class I complex cell surface expression Clathrin derived vesicle budding Lysosome Vesicle Biogenesis MHC class II antigen presentation trans-Golgi Network Vesicle Budding Adaptive Immune System
Drugs
Diseases
GWAS			Carotid atherosclerosis in HIV infection ( 20009918)
Protein-Protein Interactions		47 interactors: ADRB2 AGTR1 AP1B1 AP2M1 ARF6 AVPR2 C5AR1 CDC42 CLTC CSNK2A1 CSNK2A2 CXCR4 CYTH2 DVL2 FLNA FZD4 HCRTR1 HIPK3 HTR2C ITCH LHCGR LIMK1 MAP2K4 MAP3K5 MAPK1 MAPK10 MAPK9 MDM2 MED8 NDUFS7 NFKBIA NTS NTSR1 OPRD1 OXTR PARK2 PDE4D PTAFR PTGDS RAF1 RALGDS SLC9A5 SMARCC2 STC2 TGFBR3 TRH USP33	22 interactors: AMPH AP1G1 AP1M1 AP1M2 ARF1 ARF5 ARF6 ARRB2 ATF7IP ATM ATR BARD1 BUB1 BUB1B CLTC CREBBP KIF13A NTRK2 PIP5K1C PRKDC SHBG SMAD2
Entrez ID		409	162
HPRD ID		00147	02541
Ensembl ID		ENSG00000141480	ENSG00000100280
Uniprot IDs		K7ENA6 P32121 Q59EM5	Q10567
PDB IDs			4HMY
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Signaling Signal Transduction Regulation Of Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Response To External Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Stress-activated MAPK Cascade Immune Response-regulating Signaling Pathway Intracellular Signal Transduction Cellular Response To Organic Substance Response To Stimulus Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of JNK Cascade Response To Organic Substance Positive Regulation Of MAPK Cascade Regulation Of Protein Phosphorylation Chemotaxis Positive Regulation Of Protein Modification Process Regulation Of Catalytic Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Phosphorylation Locomotion Immune System Process Regulation Of Metabolic Process Regulation Of Cellular Process Positive Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Fc Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Apoptotic Process Response To Stress Positive Regulation Of Cellular Metabolic Process Programmed Cell Death Regulation Of MAP Kinase Activity Response To Lipid	Post-Golgi Vesicle-mediated Transport Regulation Of Defense Response To Virus By Virus Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Protein Localization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Organelle Organization Golgi Vesicle Transport Protein Transport Establishment Of Protein Localization Cellular Localization Viral Process Regulation Of Defense Response To Virus Establishment Of Vesicle Localization Melanosome Organization Pigment Granule Organization Vesicle Localization Cell Cycle Cell Cycle Checkpoint Antigen Processing And Presentation Of Peptide Antigen Cell Cycle Process Regulation Of Cellular Response To Heat Regulation Of Cellular Component Organization Establishment Of Localization In Cell Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Antigen Processing And Presentation Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Chromosome Segregation Negative Regulation Of Mitotic Cell Cycle Phase Transition Establishment Of Organelle Localization Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Cell Differentiation Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Cell Cycle Checkpoint Negative Regulation Of Proteolysis Cellular Protein Localization Response To Gamma Radiation Negative Regulation Of Protein Processing Cellular Pigmentation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Temperature Stimulus Endosome To Melanosome Transport Pigment Granule Maturation Regulation Of Protein Processing Negative Regulation Of Proteasomal Protein Catabolic Process
Tagcloud ?		17p13 22q11 adrbk2 adrenergic ark ark1 ark2 arrestin assignment band chromosome coding cofactor coupled desensitization grk4 grk5 grk6 includes it11 mapped mapping multigene occupied phosphorylates q37 refine rhodopsin sag
Tagcloud (Difference) ?		17p13 22q11 adrbk2 adrenergic ark ark1 ark2 arrestin assignment band chromosome coding cofactor coupled desensitization grk4 grk5 grk6 includes it11 mapped mapping multigene occupied phosphorylates q37 refine rhodopsin sag
Tagcloud (Intersection) ?