ARRB2 and NTS

Number of citations of the paper that reports this interaction (PubMedID 12473660)
0

Data Source:
HPRD (in vitro, in vivo)

		ARRB2	NTS
Description		arrestin beta 2	neurotensin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane Endocytic Vesicle Endocytic Vesicle Membrane Cytoplasmic Vesicle Postsynapse Glutamatergic Synapse	Extracellular Region Transport Vesicle Cytoplasmic Vesicle Axon Terminus
	Molecular Function	G Protein-coupled Receptor Binding Signaling Receptor Binding Protein Binding Enzyme Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Angiotensin Receptor Binding D1 Dopamine Receptor Binding Protein Kinase B Binding Molecular Adaptor Activity	Neuropeptide Hormone Activity Protein Binding Receptor Ligand Activity Neuropeptide Receptor Binding
	Biological Process	Desensitization Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Internalization Positive Regulation Of Receptor Internalization Transcription By RNA Polymerase II Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Adult Walking Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Protein Transport Protein Ubiquitination Sensory Perception Of Pain Negative Regulation Of Protein Ubiquitination Receptor Internalization Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Modulation Of Chemical Synaptic Transmission Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Excitatory Postsynaptic Potential Cell Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Postsynaptic Signal Transduction Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cardiac Muscle Cell Differentiation	Signal Transduction Neuropeptide Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Killing Of Cells Of Another Organism Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Blood Vessel Diameter Maintenance
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus G alpha (s) signalling events Thrombin signalling through proteinase activated receptors (PARs) WNT5A-dependent internalization of FZD4 Activation of SMO Activation of SMO MAP2K and MAPK activation Ub-specific processing proteases Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Signaling downstream of RAS mutants Signaling by RAF1 mutants TGFBR3 regulates TGF-beta signaling	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs
Diseases
GWAS		Behcet's disease ( 33393726) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) White blood cell count ( 32888494)	Metabolite levels ( 23823483)
Interacting Genes		60 interacting genes: ADRB2 AGTR1 AGTR2 AP1B1 AP2M1 ARF6 AVPR2 BCAS1 C5AR1 CDC42 CLTC CRHR1 CSNK2A1 CSNK2A2 CXCR4 CYTH2 DLG4 DVL2 EGFR EIF2AK4 FLNA FZD4 HCRTR1 HIPK3 HTR2C ITCH LHCGR LIMK1 MAP2K4 MAP3K5 MAPK1 MAPK10 MAPK9 MAS1 MDM2 MED8 NDUFS7 NEDD4L NFKBIA NTS NTSR1 OPRD1 OXER1 OXTR PDE4D PTAFR PTGDS RAF1 RALGDS RHO SLC9A5 SMARCC2 SNCA STC2 SUMO1 SUMO2 TGFBR3 TRH UBC UBE2I	10 interacting genes: ACE2 ARRB2 CPE MEP1A MFF NLN NTSR1 NTSR2 PREP SORT1
Entrez ID		409	4922
HPRD ID		00147	08878
Ensembl ID		ENSG00000141480	ENSG00000133636
Uniprot IDs		K7ENA6 P32121 Q59EM5 Q68DZ5	P30990 Q6FH20
PDB IDs			2LNE 2LNF 2LNG 2LYW 2OYV 2OYW 3F6K 4PO7 5LUZ 6UP7 8VJY
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Plasma Membrane Signal Transduction Regulation Of Biological Quality Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Regulation Of Multicellular Organismal Process Protein Serine Kinase Activity Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Intracellular Signal Transduction Protein Serine/threonine Kinase Activity Protein Kinase Activity Clathrin-coated Endocytic Vesicle Membrane Angiotensin Type II Receptor Activity Regulation Of Transport Positive Regulation Of Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Metal Ion Transport Regulation Of MAPK Cascade Regulation Of System Process Regulation Of Systemic Arterial Blood Pressure Glutamatergic Synapse Regulation Of Developmental Process Positive Regulation Of Locomotion Negative Regulation Of Systemic Arterial Blood Pressure Ubiquitin Protein Ligase Binding Enzyme Binding Blood Vessel Diameter Maintenance Regulation Of Tube Size Kinase Activity Import Into Cell Postsynapse Regulation Of Monoatomic Ion Transport Response To Stress Regulation Of Blood Pressure Neuron Spine Positive Regulation Of Neuron Projection Arborization Endocytosis Positive Regulation Of Cell Migration	Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Neuropeptide Signaling Pathway Metallocarboxypeptidase Activity G Protein-coupled Neurotensin Receptor Activity Metallopeptidase Activity Hormone Metabolic Process Peptidase Activity Protein Processing Proteolysis Protein Maturation Angiotensin Maturation G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Amino Acid Transport Carboxypeptidase Activity Regulation Of Biological Quality Regulation Of Hormone Levels Import Into Cell Peptide Metabolic Process Neurotensin Receptor Activity, Non-G Protein-coupled Plasma Membrane Endocytic Vesicle Membrane Angiotensin Receptor Binding Clathrin-coated Pit Adult Locomotory Behavior Cytoplasmic Vesicle Epidermal Growth Factor Receptor Ligand Maturation Meprin A Complex Inositol Phosphate Catabolic Process Regulation Of Amine Transport Oligopeptidase Activity Nerve Growth Factor Receptor Activity Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Peptidyl-dipeptidase Activity Regulation Of Striated Muscle Cell Differentiation Hydrolase Activity Metalloendopeptidase Activity Positive Regulation Of Synaptic Transmission, Dopaminergic Regulation Of Membrane Potential Membrane Protein Localization To Secretory Granule Positive Regulation Of Gamma-aminobutyric Acid Secretion Entry Receptor-mediated Virion Attachment To Host Cell Endocytosis Amino Acid Transport Symmetric Synapse Regulation Of Skeletal Muscle Fiber Differentiation Viral Translation Viral Life Cycle
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