ARRB2 and NTSR1

Number of citations of the paper that reports this interaction (PubMedID 11279203)
0

Data Source:
HPRD (in vivo)

		ARRB2	NTSR1
Description		arrestin beta 2	neurotensin receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane Endocytic Vesicle Endocytic Vesicle Membrane Cytoplasmic Vesicle Postsynapse Glutamatergic Synapse	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Membrane Axon Dendrite Symmetric Synapse Neuronal Cell Body Terminal Bouton Dendritic Spine Dendritic Shaft Perikaryon Axon Terminus Neuron Spine Membrane Raft
	Molecular Function	G Protein-coupled Receptor Binding Signaling Receptor Binding Protein Binding Enzyme Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Angiotensin Receptor Binding D1 Dopamine Receptor Binding Protein Kinase B Binding Molecular Adaptor Activity	G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Neurotensin Receptor Activity Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Desensitization Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Internalization Positive Regulation Of Receptor Internalization Transcription By RNA Polymerase II Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Adult Walking Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Protein Transport Protein Ubiquitination Sensory Perception Of Pain Negative Regulation Of Protein Ubiquitination Receptor Internalization Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Modulation Of Chemical Synaptic Transmission Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Excitatory Postsynaptic Potential Cell Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Postsynaptic Signal Transduction Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cardiac Muscle Cell Differentiation	Temperature Homeostasis Negative Regulation Of Systemic Arterial Blood Pressure Regulation Of Membrane Depolarization CAMP Biosynthetic Process Response To Stress Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Learning Associative Learning Adult Locomotory Behavior Positive Regulation Of Gene Expression Positive Regulation Of Glutamate Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Response To Food Regulation Of Inositol Trisphosphate Biosynthetic Process Response To Lipid Positive Regulation Of Locomotion Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Respiratory Gaseous Exchange Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Inositol Phosphate Biosynthetic Process D-aspartate Import Across Plasma Membrane Inositol Phosphate Catabolic Process Vocalization Behavior Positive Regulation Of Arachidonate Secretion Positive Regulation Of Inhibitory Postsynaptic Potential L-glutamate Import Across Plasma Membrane Conditioned Place Preference Regulation Of Behavioral Fear Response
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus G alpha (s) signalling events Thrombin signalling through proteinase activated receptors (PARs) WNT5A-dependent internalization of FZD4 Activation of SMO Activation of SMO MAP2K and MAPK activation Ub-specific processing proteases Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Signaling downstream of RAS mutants Signaling by RAF1 mutants TGFBR3 regulates TGF-beta signaling	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs
Diseases
GWAS		Behcet's disease ( 33393726) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) White blood cell count ( 32888494)	Cellular nuclear factor (erythroid-derived 2)-like 2 levels ( 30767168) Metabolite levels ( 23823483)
Interacting Genes		60 interacting genes: ADRB2 AGTR1 AGTR2 AP1B1 AP2M1 ARF6 AVPR2 BCAS1 C5AR1 CDC42 CLTC CRHR1 CSNK2A1 CSNK2A2 CXCR4 CYTH2 DLG4 DVL2 EGFR EIF2AK4 FLNA FZD4 HCRTR1 HIPK3 HTR2C ITCH LHCGR LIMK1 MAP2K4 MAP3K5 MAPK1 MAPK10 MAPK9 MAS1 MDM2 MED8 NDUFS7 NEDD4L NFKBIA NTS NTSR1 OPRD1 OXER1 OXTR PDE4D PTAFR PTGDS RAF1 RALGDS RHO SLC9A5 SMARCC2 SNCA STC2 SUMO1 SUMO2 TGFBR3 TRH UBC UBE2I	2 interacting genes: ARRB2 NTS
Entrez ID		409	4923
HPRD ID		00147	01218
Ensembl ID		ENSG00000141480	ENSG00000101188
Uniprot IDs		K7ENA6 P32121 Q59EM5 Q68DZ5	P30989
PDB IDs			2LYW 6OS9 6OSA 6PWC 6UP7 7UL2 8JPB 8JPC 8JPF
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Plasma Membrane Signal Transduction Regulation Of Biological Quality Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Regulation Of Multicellular Organismal Process Protein Serine Kinase Activity Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Intracellular Signal Transduction Protein Serine/threonine Kinase Activity Protein Kinase Activity Clathrin-coated Endocytic Vesicle Membrane Angiotensin Type II Receptor Activity Regulation Of Transport Positive Regulation Of Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Metal Ion Transport Regulation Of MAPK Cascade Regulation Of System Process Regulation Of Systemic Arterial Blood Pressure Glutamatergic Synapse Regulation Of Developmental Process Positive Regulation Of Locomotion Negative Regulation Of Systemic Arterial Blood Pressure Ubiquitin Protein Ligase Binding Enzyme Binding Blood Vessel Diameter Maintenance Regulation Of Tube Size Kinase Activity Import Into Cell Postsynapse Regulation Of Monoatomic Ion Transport Response To Stress Regulation Of Blood Pressure Neuron Spine Positive Regulation Of Neuron Projection Arborization Endocytosis Positive Regulation Of Cell Migration	Protein Kinase B Binding Regulation Of Interleukin-12 Production Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Angiotensin Receptor Binding Regulation Of Interleukin-6 Production Regulation Of Protein Ubiquitination Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Gene Expression Regulation Of Lymphocyte Mediated Immunity Neuropeptide Receptor Binding Protein-macromolecule Adaptor Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Synaptic Transmission, Dopaminergic Regulation Of Post-translational Protein Modification Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication D1 Dopamine Receptor Binding Negative Adaptation Of Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Signaling Regulation Of Canonical NF-kappaB Signal Transduction Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Interleukin-17A-mediated Signaling Pathway Regulation Of Synaptic Transmission, Dopaminergic Interleukin-33-mediated Signaling Pathway DNA-templated Transcription Enzyme Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Innate Immune Response Positive Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Positive Regulation Of Cardiac Muscle Cell Differentiation CD40 Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway CD40 Receptor Complex Positive Regulation Of JUN Kinase Activity TRIF-dependent Toll-like Receptor Signaling Pathway T-helper 1 Type Immune Response Interleukin-17-mediated Signaling Pathway G Protein-coupled Receptor Internalization Negative Regulation Of Biosynthetic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Cardiocyte Differentiation MyD88-dependent Toll-like Receptor Signaling Pathway Ubiquitin-ubiquitin Ligase Activity
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