CHEK1 and SMAD4

Number of citations of the paper that reports this interaction (PMID 15761153)
154

Data Source:
HPRD (in vivo)

		CHEK1	SMAD4
Gene Name		checkpoint kinase 1	SMAD family member 4
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Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Condensed Nuclear Chromosome Extracellular Space Nucleus Nucleoplasm Replication Fork Centrosome Cytosol Intracellular Membrane-bounded Organelle	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Centrosome Cytosol Activin Responsive Factor Complex SMAD Protein Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Histone Kinase Activity (H3-T11 Specific)	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Core Promoter Proximal Region Sequence-specific DNA Binding Protein Binding Transcription Factor Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Factor Binding DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Collagen Binding Transforming Growth Factor Beta Receptor, Common-partner Cytoplasmic Mediator Activity Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Metal Ion Binding I-SMAD Binding R-SMAD Binding
	Biological Process	DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Peptidyl-threonine Phosphorylation G2 DNA Damage Checkpoint Histone H3-T11 Phosphorylation Regulation Of Cell Proliferation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Centrosome Separation Chromatin-mediated Maintenance Of Transcription Cellular Response To Mechanical Stimulus Cellular Response To Caffeine Replicative Senescence Negative Regulation Of DNA Biosynthetic Process Regulation Of Histone H3-K9 Acetylation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Branching Involved In Ureteric Bud Morphogenesis Response To Hypoxia In Utero Embryonic Development Gastrulation With Mouth Forming Second Atrioventricular Valve Formation Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Cardiac Septum Development Brainstem Development Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Axon Guidance Endoderm Development Mesoderm Development Cell Proliferation Negative Regulation Of Cell Proliferation Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Neural Crest Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Growth BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of BMP Signaling Pathway Somite Rostral/caudal Axis Specification Regulation Of Transforming Growth Factor Beta2 Production Somatic Stem Cell Maintenance Intracellular Signal Transduction Atrioventricular Canal Development Endothelial Cell Activation Negative Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Developmental Growth Neuron Fate Commitment Sebaceous Gland Development Formation Of Anatomical Boundary Regulation Of Binding Regulation Of Hair Follicle Development Palate Development Positive Regulation Of SMAD Protein Import Into Nucleus SMAD Protein Signal Transduction Negative Regulation Of Cell Death Endocardial Cell Differentiation Response To Transforming Growth Factor Beta Metanephric Mesenchyme Morphogenesis Nephrogenic Mesenchyme Morphogenesis
Pathways		Signaling by SCF-KIT Ubiquitin Mediated Degradation of Phosphorylated Cdc25A G2/M DNA damage checkpoint G2/M Checkpoints Activation of ATR in response to replication stress Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex p53-Independent DNA Damage Response Cell Cycle Checkpoints p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints	Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by BMP Transcriptional regulation of pluripotent stem cells Generic Transcription Pathway Signaling by NODAL TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by Activin TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS			Immune response to anthrax vaccine ( 22658931)
Protein-Protein Interactions		37 interactors: AATF AKT1 APP ATM ATR BLM BRCA1 CDC25A CDC25B CDC25C CHUK CLSPN CSNK2B CUL1 CUL4A DTL FANCE HSP90AA1 LATS2 MCPH1 MDM4 PIGM PRKDC RAD51 RB1 RELA SMAD4 TIMELESS TLK1 TOPBP1 TP53 UBB USP7 XIAP XPO1 XRCC6 YWHAG	174 interactors: ACVR1B AKT1 AP2B1 APBB2 AR ARFRP1 ARL5B ATF2 ATF7IP BRCA1 BTRC CAMK2G CD59 CEBPA CEBPB CEBPD CHEK1 CITED1 CNKSR1 COPS5 CREBBP CSH1 CSH2 CTCF CTNNB1 CYFIP2 DACH1 DCP1A DCP1B DLX1 DNAJB2 DVL1 ECSIT EEF1A1 EID2 EIF2AK4 EP300 ERBB2IP ESR1 ESR2 EWSR1 FBLN1 FBXO30 FBXO34 FHL2 FHL3 FN1 FOXG1 FOXH1 FOXO1 FOXO3 FOXO4 FSTL3 GATA2 GLI3 GPNMB HDGF HDLBP HMG20A HNF4A HOXA9 HOXC8 ITK JUN JUNB JUND LEF1 LMO4 MAPK1 MAPK13 MAX MDM4 MECOM MEF2A MEX3B MYOD1 NAT8 NEK6 NELFCD NF1 NKX3-2 NOTCH4 NR0B2 NRAS NUAK2 NUP214 OTUB1 PAK1 PAPPA2 PARD3 PARD3B PBK PIAS1 PIAS2 PIAS3 PIAS4 PLG PLK4 PRKAR1B PRKAR2A PRPF40A PSG2 PSG9 PSMD11 RAB13 RAB25 RAB2B RAB34 RAB38 RAB3B RAC2 RALA RASD2 RASL12 RASSF5 RBL1 RELA RFX1 RHEBL1 RHOD RHOG RHOJ RIPK2 RMND5B RPL28 RPS27A RRAS2 RSPH14 SASH3 SERPINA1 SKI SKIL SKP2 SMAD1 SMAD2 SMAD3 SMAD5 SMAD7 SMAD9 SNIP1 SNRNP70 SNW1 SOX12 SP1 SPTBN1 SQSTM1 STK11IP STK35 STUB1 TCTA TDG TENM3 TFE3 TGFBR1 TGFBR2 TGFBRAP1 TM9SF2 TOB1 TRAP1 TSSK3 UBA52 UBB UBE2I UBE2L3 UBE2Z UHRF2 USB1 USP9X XPO5 ZBED5 ZMYM2 ZNF423 ZNF521 ZNF8
Entrez ID		1111	4089
HPRD ID		04356	02995
Ensembl ID		ENSG00000149554	ENSG00000141646
Uniprot IDs		B4DT73 O14757	Q13485
PDB IDs		1IA8 1NVQ 1NVR 1NVS 1ZLT 1ZYS 2AYP 2BR1 2BRB 2BRG 2BRH 2BRM 2BRN 2BRO 2C3J 2C3K 2C3L 2CGU 2CGV 2CGW 2CGX 2E9N 2E9O 2E9P 2E9U 2E9V 2GDO 2GHG 2HOG 2HXL 2HXQ 2HY0 2QHM 2QHN 2R0U 2WMQ 2WMR 2WMS 2WMT 2WMU 2WMV 2WMW 2WMX 2X8D 2X8E 2X8I 2XEY 2XEZ 2XF0 2YDI 2YDJ 2YDK 2YER 2YEX 2YM3 2YM4 2YM5 2YM6 2YM7 2YM8 2YWP 3F9N 3JVR 3JVS 3NLB 3OT3 3OT8 3PA3 3PA4 3PA5 3TKH 3TKI 3U9N 4FSM 4FSN 4FSQ 4FSR 4FST 4FSU 4FSW 4FSY 4FSZ 4FT0 4FT3 4FT5 4FT7 4FT9 4FTA 4FTC 4FTI 4FTJ 4FTK 4FTL 4FTM 4FTN 4FTO 4FTQ 4FTR 4FTT 4FTU 4GH2 4HYH 4HYI 4JIK	1DD1 1G88 1MR1 1U7F 1U7V 1YGS
Enriched GO Terms of Interacting Partners?		Cell Cycle Cell Cycle Process Mitotic Cell Cycle Regulation Of Cell Cycle Cellular Response To DNA Damage Stimulus Regulation Of Protein Metabolic Process Cellular Response To Stress Mitotic Cell Cycle Process Regulation Of Cell Cycle Process Response To Abiotic Stimulus Response To Radiation DNA Repair Cell Cycle Phase Transition Cellular Response To Stimulus Response To Stress DNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Phase Transition Response To Ionizing Radiation Regulation Of Mitotic Cell Cycle DNA Damage Checkpoint Cell Cycle Checkpoint Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Apoptotic Signaling Pathway Regulation Of Metabolic Process Response To Stimulus Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Double-strand Break Repair Apoptotic Process Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Programmed Cell Death Regulation Of Phosphorus Metabolic Process Cell Death Death Regulation Of Protein Catabolic Process Cellular Response To Ionizing Radiation Positive Regulation Of Cell Cycle Intracellular Signal Transduction Regulation Of Protein Kinase Activity G2/M Transition Of Mitotic Cell Cycle Cellular Protein Modification Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Cellular Response To Radiation Regulation Of Cell Cycle Phase Transition	Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Enzyme Linked Receptor Protein Signaling Pathway Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Regulation Of Cellular Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Growth Factor Negative Regulation Of Transcription, DNA-templated Cellular Response To Stimulus Response To Organic Substance Response To Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Signal Transduction Cell Communication Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Signaling Response To Transforming Growth Factor Beta Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Developmental Process
Tagcloud ?		aggressive atr bcss clinically consequences cytoplasmic deregulated doxycycline knock lymphovascular mb mcf10a mcf7 mda mitotic personalized phenotypes pleomorphism positivity predictor rational restored ser345 serine345 signalling tumorigenic univariate ve	adenoviral autoinhibitory cdk coactivators competing conformational constructs creb define e1a effector facilitating fragment interacting modulates oncoprotein p15 p300 participate possibility potentiates removes smad3 smads squelching tgf transactivation transduce
Tagcloud (Difference) ?		aggressive atr bcss clinically consequences cytoplasmic deregulated doxycycline knock lymphovascular mb mcf10a mcf7 mda mitotic personalized phenotypes pleomorphism positivity predictor rational restored ser345 serine345 signalling tumorigenic univariate ve	adenoviral autoinhibitory cdk coactivators competing conformational constructs creb define e1a effector facilitating fragment interacting modulates oncoprotein p15 p300 participate possibility potentiates removes smad3 smads squelching tgf transactivation transduce
Tagcloud (Intersection) ?