CHEK1 and LATS2

Number of citations of the paper that reports this interaction (PMID 21118956)
5

Data Source:
BioGRID (enzymatic study, enzymatic study)

		CHEK1	LATS2
Gene Name		checkpoint kinase 1	large tumor suppressor kinase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Condensed Nuclear Chromosome Extracellular Space Nucleus Nucleoplasm Replication Fork Centrosome Cytosol Intracellular Membrane-bounded Organelle	Spindle Pole Nucleus Cytoplasm Microtubule Organizing Center Cytosol
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Histone Kinase Activity (H3-T11 Specific)	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Peptidyl-threonine Phosphorylation G2 DNA Damage Checkpoint Histone H3-T11 Phosphorylation Regulation Of Cell Proliferation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Centrosome Separation Chromatin-mediated Maintenance Of Transcription Cellular Response To Mechanical Stimulus Cellular Response To Caffeine Replicative Senescence Negative Regulation Of DNA Biosynthetic Process Regulation Of Histone H3-K9 Acetylation	G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Mitotic Nuclear Division Hormone-mediated Signaling Pathway Keratinocyte Differentiation Cellular Protein Localization Hippo Signaling Intracellular Signal Transduction Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Signaling by SCF-KIT Ubiquitin Mediated Degradation of Phosphorylated Cdc25A G2/M DNA damage checkpoint G2/M Checkpoints Activation of ATR in response to replication stress Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex p53-Independent DNA Damage Response Cell Cycle Checkpoints p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints	Signaling by Hippo
Drugs
Diseases
GWAS
Protein-Protein Interactions		37 interactors: AATF AKT1 APP ATM ATR BLM BRCA1 CDC25A CDC25B CDC25C CHUK CLSPN CSNK2B CUL1 CUL4A DTL FANCE HSP90AA1 LATS2 MCPH1 MDM4 PIGM PRKDC RAD51 RB1 RELA SMAD4 TIMELESS TLK1 TOPBP1 TP53 UBB USP7 XIAP XPO1 XRCC6 YWHAG	19 interactors: ABL1 AJUBA AMOT AURKB CDK2 CDKN1A CHEK1 CHEK2 CTNNB1 DYRK1A MOB3A MOB3B MOB3C MOB4 SNAI1 STK3 TAZ YAP1 YWHAG
Entrez ID		1111	26524
HPRD ID		04356	07277
Ensembl ID		ENSG00000149554	ENSG00000150457
Uniprot IDs		B4DT73 O14757	Q9NRM7
PDB IDs		1IA8 1NVQ 1NVR 1NVS 1ZLT 1ZYS 2AYP 2BR1 2BRB 2BRG 2BRH 2BRM 2BRN 2BRO 2C3J 2C3K 2C3L 2CGU 2CGV 2CGW 2CGX 2E9N 2E9O 2E9P 2E9U 2E9V 2GDO 2GHG 2HOG 2HXL 2HXQ 2HY0 2QHM 2QHN 2R0U 2WMQ 2WMR 2WMS 2WMT 2WMU 2WMV 2WMW 2WMX 2X8D 2X8E 2X8I 2XEY 2XEZ 2XF0 2YDI 2YDJ 2YDK 2YER 2YEX 2YM3 2YM4 2YM5 2YM6 2YM7 2YM8 2YWP 3F9N 3JVR 3JVS 3NLB 3OT3 3OT8 3PA3 3PA4 3PA5 3TKH 3TKI 3U9N 4FSM 4FSN 4FSQ 4FSR 4FST 4FSU 4FSW 4FSY 4FSZ 4FT0 4FT3 4FT5 4FT7 4FT9 4FTA 4FTC 4FTI 4FTJ 4FTK 4FTL 4FTM 4FTN 4FTO 4FTQ 4FTR 4FTT 4FTU 4GH2 4HYH 4HYI 4JIK
Enriched GO Terms of Interacting Partners?		Cell Cycle Cell Cycle Process Mitotic Cell Cycle Regulation Of Cell Cycle Cellular Response To DNA Damage Stimulus Regulation Of Protein Metabolic Process Cellular Response To Stress Mitotic Cell Cycle Process Regulation Of Cell Cycle Process Response To Abiotic Stimulus Response To Radiation DNA Repair Cell Cycle Phase Transition Cellular Response To Stimulus Response To Stress DNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Phase Transition Response To Ionizing Radiation Regulation Of Mitotic Cell Cycle DNA Damage Checkpoint Cell Cycle Checkpoint Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Apoptotic Signaling Pathway Regulation Of Metabolic Process Response To Stimulus Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Double-strand Break Repair Apoptotic Process Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Programmed Cell Death Regulation Of Phosphorus Metabolic Process Cell Death Death Regulation Of Protein Catabolic Process Cellular Response To Ionizing Radiation Positive Regulation Of Cell Cycle Intracellular Signal Transduction Regulation Of Protein Kinase Activity G2/M Transition Of Mitotic Cell Cycle Cellular Protein Modification Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Cellular Response To Radiation Regulation Of Cell Cycle Phase Transition	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Cell Cycle Hippo Signaling Regulation Of Cellular Component Organization Positive Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Cycle Mitotic Cell Cycle Phase Transition Regulation Of Protein Metabolic Process Cell Cycle Phase Transition DNA Damage Induced Protein Phosphorylation Positive Regulation Of Stem Cell Differentiation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Developmental Process Intrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction Regulation Of Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Signal Transduction Regulation Of Mitotic Cell Cycle Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Protein Autophosphorylation Cell Cycle Checkpoint Negative Regulation Of Signaling Negative Regulation Of Kinase Activity Regulation Of Metabolic Process Regulation Of Gene Expression Signal Transduction In Response To DNA Damage Regulation Of Nitrogen Compound Metabolic Process Regulation Of Signaling Regulation Of Cell Cycle Process Protein Phosphorylation Phosphorylation Intracellular Signal Transduction Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle Negative Regulation Of Transferase Activity Regulation Of Wnt Signaling Pathway Regulation Of Response To DNA Damage Stimulus Histone Phosphorylation Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of RNA Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Proliferation Cellular Response To Radiation Apoptotic Signaling Pathway
Tagcloud ?		aggressive atr bcss clinically consequences cytoplasmic deregulated doxycycline knock lymphovascular mb mcf10a mcf7 mda mitotic personalized phenotypes pleomorphism positivity predictor rational restored ser345 serine345 signalling tumorigenic univariate ve	address approach bioinformatics carried challenging contribute damage discovery efficiently especially genome hlats1 lats1 mutations numerous opportunities powerful predicted projects putative question regulators silico sort support suppressor suppressors understood unprecedented
Tagcloud (Difference) ?		aggressive atr bcss clinically consequences cytoplasmic deregulated doxycycline knock lymphovascular mb mcf10a mcf7 mda mitotic personalized phenotypes pleomorphism positivity predictor rational restored ser345 serine345 signalling tumorigenic univariate ve	address approach bioinformatics carried challenging contribute damage discovery efficiently especially genome hlats1 lats1 mutations numerous opportunities powerful predicted projects putative question regulators silico sort support suppressor suppressors understood unprecedented
Tagcloud (Intersection) ?