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CHEK1 and FANCE
Number of citations of the paper that reports this interaction (PubMedID
17296736
)
32
Data Source:
BioGRID
(enzymatic study)
CHEK1
FANCE
Description
checkpoint kinase 1
FA complementation group E
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Condensed Nuclear Chromosome
Extracellular Space
Nucleus
Nucleoplasm
Replication Fork
Chromosome
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Protein-containing Complex
Chromatin
Nucleus
Nucleoplasm
Chromosome
Centrosome
Cytosol
Fanconi Anaemia Nuclear Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Domain Specific Binding
Histone H3T11 Kinase Activity
Protein Serine Kinase Activity
Protein Binding
Biological Process
DNA Damage Checkpoint Signaling
G2/M Transition Of Mitotic Cell Cycle
Inner Cell Mass Cell Proliferation
DNA Replication
DNA Repair
Chromatin Remodeling
Protein Phosphorylation
Apoptotic Process
DNA Damage Response
Nucleus Organization
Nuclear Envelope Organization
Mitotic Nuclear Membrane Disassembly
Mitotic G2 DNA Damage Checkpoint Signaling
Regulation Of Gene Expression
Regulation Of Double-strand Break Repair Via Homologous Recombination
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Peptidyl-threonine Phosphorylation
Regulation Of Cell Population Proliferation
Signal Transduction In Response To DNA Damage
Mitotic G2/M Transition Checkpoint
Positive Regulation Of Cell Cycle
Negative Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Mitotic Nuclear Division
Regulation Of Mitotic Centrosome Separation
Negative Regulation Of G0 To G1 Transition
Cellular Response To Mechanical Stimulus
Replicative Senescence
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Cell Cycle Phase Transition
Apoptotic Process Involved In Development
Ovarian Follicle Development
DNA Repair
DNA Damage Response
Gene Expression
Interstrand Cross-link Repair
Homeostasis Of Number Of Cells
Pathways
Signaling by SCF-KIT
Activation of ATR in response to replication stress
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
TP53 Regulates Transcription of DNA Repair Genes
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Transcriptional Regulation by E2F6
Fanconi Anemia Pathway
PKR-mediated signaling
Drugs
XL844
Enzastaurin
CHIR-124
N-{5-[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]-1H-PYRROLO[2,3-B]PYRIDIN-3-YL}NICOTINAMIDE
3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)QUINOLIN-2(1H)-ONE
2,2'-{[9-(HYDROXYIMINO)-9H-FLUORENE-2,7-DIYL]BIS(OXY)}DIACETIC ACID
(2S)-1-AMINO-3-[(5-NITROQUINOLIN-8-YL)AMINO]PROPAN-2-OL
2-(cyclohexylamino)benzoic acid
3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)-1H-INDAZOLE-6-CARBONITRILE
(3Z)-6-(4-HYDROXY-3-METHOXYPHENYL)-3-(1H-PYRROL-2-YLMETHYLENE)-1,3-DIHYDRO-2H-INDOL-2-ONE
5-ETHYL-3-METHYL-1,5-DIHYDRO-4H-PYRAZOLO[4,3-C]QUINOLIN-4-ONE
(5-{3-[5-(PIPERIDIN-1-YLMETHYL)-1H-INDOL-2-YL]-1H-INDAZOL-6-YL}-2H-1,2,3-TRIAZOL-4-YL)METHANOL
1-(5-CHLORO-2-METHOXYPHENYL)-3-{6-[2-(DIMETHYLAMINO)-1-METHYLETHOXY]PYRAZIN-2-YL}UREA
(3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLATE
18-CHLORO-11,12,13,14-TETRAHYDRO-1H,10H-8,4-(AZENO)-9,15,1,3,6-BENZODIOXATRIAZACYCLOHEPTADECIN-2-ONE
1-(5-CHLORO-2,4-DIMETHOXYPHENYL)-3-(5-CYANOPYRAZIN-2-YL)UREA
4-(6-{[(4-METHYLCYCLOHEXYL)AMINO]METHYL}-1,4-DIHYDROINDENO[1,2-C]PYRAZOL-3-YL)BENZOIC ACID
4-[3-(1H-BENZIMIDAZOL-2-YL)-1H-INDAZOL-6-YL]-2-METHOXYPHENOL
(2R)-1-[(5,6-DIPHENYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)AMINO]PROPAN-2-OL
(2R)-3-{[(4Z)-5,6-DIPHENYL-6,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-YLIDENE]AMINO}PROPANE-1,2-DIOL
N-(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)GLYCINE
(5,6-DIPHENYL-FURO[2,3-D]PYRIMIDIN-4-YLAMINO)-ACETIC
3-AMINO-3-BENZYL-[4.3.0]BICYCLO-1,6-DIAZANONAN-2-ONE
3-(1H-BENZIMIDAZOL-2-YL)-1H-INDAZOLE
2-[5,6-BIS-(4-METHOXY-PHENYL)-FURO[2,3-D]PYRIMIDIN-4-YLAMINO]-ETHANOL
2-[(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)AMINO]ETHANOL
REL-(9R,12S)-9,10,11,12-TETRAHYDRO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG:3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-1,3(2H)-DIONE
1-[(2S)-4-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl)morpholin-2-yl]methanamine
N-(4-OXO-5,6,7,8-TETRAHYDRO-4H-[1,3]THIAZOLO[5,4-C]AZEPIN-2-YL)ACETAMIDE
5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE
[4-amino-2-(tert-butylamino)-1,3-thiazol-5-yl](phenyl)methanone
2-(methylsulfanyl)-5-(thiophen-2-ylmethyl)-1H-imidazol-4-ol
6-MORPHOLIN-4-YL-9H-PURINE
1-[(2S)-4-(5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDIN-4-YL)MORPHOLIN-2-YL]METHANAMINE
Prexasertib
Fostamatinib
LY-2608204
PF-477736
Diseases
Fanconi anemia
GWAS
Breast cancer (survival) (
25890600
)
Squamous cell lung carcinoma (
28604730
)
Height (
28552196
)
Ovarian cancer (
30557369
)
Pulmonary function (smoking interaction) (
23284291
)
Interacting Genes
61 interacting genes:
AATF
AKT1
APP
ATM
ATR
ATXN3
BAD
BCL2L1
BLM
BRCA1
BRCA2
CDC14B
CDC25A
CDC25B
CDC25C
CDH1
CEBPA
CHUK
CLSPN
CNTN2
CSNK2B
CUL1
CUL4A
DBF4
DTL
FANCE
HSP90AA1
ILKAP
LATS2
MAPT
MCM6
MCM7
MCPH1
MDM4
MED1
NPM1
PIGM
PPP1R12A
PRKAA1
PRKDC
RAD23A
RAD51
RB1
RELA
SMAD4
TIMELESS
TLK1
TOPBP1
TP53
TP53BP1
TRAF4
UBA1
UBA2
UBB
UBC
UBE2T
USP3
XIAP
XPO1
XRCC6
YWHAG
8 interacting genes:
BRCA2
CHEK1
FANCA
FANCC
FANCD2
FANCF
FANCG
HES1
Entrez ID
1111
2178
HPRD ID
04356
02943
Ensembl ID
ENSG00000149554
ENSG00000112039
Uniprot IDs
B4DT73
E7EPP6
O14757
A0A8Q3WL50
A0A8Q3WMB8
Q9HB96
PDB IDs
1IA8
1NVQ
1NVR
1NVS
1ZLT
1ZYS
2AYP
2BR1
2BRB
2BRG
2BRH
2BRM
2BRN
2BRO
2C3J
2C3K
2C3L
2CGU
2CGV
2CGW
2CGX
2E9N
2E9O
2E9P
2E9U
2E9V
2GDO
2GHG
2HOG
2HXL
2HXQ
2HY0
2QHM
2QHN
2R0U
2WMQ
2WMR
2WMS
2WMT
2WMU
2WMV
2WMW
2WMX
2X8D
2X8E
2X8I
2XEY
2XEZ
2XF0
2YDI
2YDJ
2YDK
2YER
2YEX
2YM3
2YM4
2YM5
2YM6
2YM7
2YM8
2YWP
3F9N
3JVR
3JVS
3NLB
3OT3
3OT8
3PA3
3PA4
3PA5
3TKH
3TKI
3U9N
4FSM
4FSN
4FSQ
4FSR
4FST
4FSU
4FSW
4FSY
4FSZ
4FT0
4FT3
4FT5
4FT7
4FT9
4FTA
4FTC
4FTI
4FTJ
4FTK
4FTL
4FTM
4FTN
4FTO
4FTQ
4FTR
4FTT
4FTU
4GH2
4HYH
4HYI
4JIK
4QYE
4QYF
4QYG
4QYH
4RVK
4RVL
4RVM
5DLS
5F4N
5OOP
5OOR
5OOT
5OP2
5OP4
5OP5
5OP7
5OPB
5OPR
5OPS
5OPU
5OPV
5OQ5
5OQ6
5OQ7
5OQ8
5WI2
6FC8
6FCF
6FCK
7AKM
7AKO
7BJD
7BJE
7BJH
7BJJ
7BJM
7BJO
7BJR
7BJX
7BK1
7BK2
7BK3
7BKN
7BKO
7MCK
7SUF
7SUG
7SUH
7SUI
7SUJ
8E80
8E81
8SIV
8SIW
8SIX
9CE4
2ILR
7KZP
7KZQ
7KZR
7KZS
7KZT
7KZV
Enriched GO Terms of Interacting Partners
?
DNA Damage Response
Cellular Response To Stress
Regulation Of Cell Cycle
Nucleoplasm
DNA Repair
Regulation Of Protein Metabolic Process
DNA Metabolic Process
Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle Process
Response To Stress
Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Nucleus
Response To Radiation
Intracellular Signal Transduction
Regulation Of Cell Cycle G2/M Phase Transition
Nucleic Acid Metabolic Process
Regulation Of Metabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Response To Ionizing Radiation
Signal Transduction In Response To DNA Damage
Nucleobase-containing Compound Metabolic Process
Regulation Of Mitotic Cell Cycle
Positive Regulation Of Protein Metabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Protein Modification Process
DNA Damage Checkpoint Signaling
Negative Regulation Of Cell Cycle
Cellular Response To Ionizing Radiation
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Response To Gamma Radiation
Regulation Of Cellular Response To Stress
Negative Regulation Of Cell Cycle Process
Cellular Response To Radiation
Regulation Of DNA Metabolic Process
Double-strand Break Repair
Negative Regulation Of Cell Cycle Phase Transition
Response To Xenobiotic Stimulus
Mitotic DNA Damage Checkpoint Signaling
Regulation Of Protein Catabolic Process
Mitotic DNA Integrity Checkpoint Signaling
Response To X-ray
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Cycle
Mitotic G2/M Transition Checkpoint
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Identical Protein Binding
Protein Modification Process
Interstrand Cross-link Repair
Fanconi Anaemia Nuclear Complex
DNA Repair
DNA Metabolic Process
DNA Damage Response
Chromatin
Cellular Response To Stress
Nucleic Acid Metabolic Process
Regulation Of CD40 Signaling Pathway
Nucleoplasm
Nucleobase-containing Compound Metabolic Process
DNA Repair Complex
Inner Cell Mass Cell Proliferation
Positive Regulation Of Mitotic Cell Cycle
Signal Transduction In Response To DNA Damage
Regulation Of Mitotic Cell Cycle
Response To Stress
Neuronal Stem Cell Population Maintenance
Female Gonad Development
Regulation Of Regulatory T Cell Differentiation
Male Meiotic Nuclear Division
Nucleotide-excision Repair
Response To Gamma Radiation
BRCA2-MAGE-D1 Complex
Nucleus
Positive Regulation Of Cell Cycle
Mitotic DNA Damage Checkpoint Signaling
Negative Regulation Of Pancreatic A Cell Differentiation
N-box Binding
Negative Regulation Of Cell Fate Determination
Positive Regulation Of Mitotic Cell Cycle, Embryonic
Trochlear Nerve Development
Mitotic DNA Integrity Checkpoint Signaling
Meiotic Nuclear Division
Regulation Of T Cell Activation
Mitotic Recombination-dependent Replication Fork Processing
Nuclear Division
Response To Radiation
Macromolecule Metabolic Process
Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle
DNA Damage Checkpoint Signaling
Negative Regulation Of Stomach Neuroendocrine Cell Differentiation
Oculomotor Nerve Development
Cajal-Retzius Cell Differentiation
Negative Regulation Of Forebrain Neuron Differentiation
Hindbrain Morphogenesis
Renal Interstitial Fibroblast Development
Histone H3T11 Kinase Activity
Regulation Of Lymphocyte Activation
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Tagcloud (Intersection)
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