ARNT and EPAS1

Number of citations: 0 (PubMedID 9079689)
Data Source: HPRD (two hybrid, in vitro, in vivo)

		ARNT	EPAS1
Name		aryl hydrocarbon receptor nuclear translocator	endothelial PAS domain protein 1
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Body Aryl Hydrocarbon Receptor Complex Nuclear Aryl Hydrocarbon Receptor Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Nuclear Speck
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Aryl Hydrocarbon Receptor Binding Protein Homodimerization Activity Sequence-specific DNA Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Response To Hypoxia Embryonic Placenta Development Positive Regulation Of Endothelial Cell Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Vascular Endothelial Growth Factor Production Cell Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Sumoylation Cellular Response To Oxidative Stress Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hormone Biosynthetic Process Negative Regulation Of Inflammatory Response Intestinal Epithelial Structure Maintenance	Angiogenesis Response To Hypoxia Embryonic Placenta Development Blood Vessel Remodeling Regulation Of Heart Rate Epithelial Cell Maturation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Response To Oxidative Stress Mitochondrion Organization Signal Transduction Visual Perception Gene Expression Hemopoiesis Cell Differentiation Erythrocyte Differentiation Lung Development Intracellular Oxygen Homeostasis Norepinephrine Metabolic Process MRNA Transcription By RNA Polymerase II Surfactant Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Myoblast Fate Commitment Multicellular Organismal-level Iron Ion Homeostasis Cellular Response To Hypoxia Positive Regulation Of Cold-induced Thermogenesis Regulation Of Protein Neddylation
Pathways		Regulation of gene expression by Hypoxia-inducible Factor PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling NPAS4 regulates expression of target genes NPAS4 regulates expression of target genes	Regulation of gene expression by Hypoxia-inducible Factor Cellular response to hypoxia Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Transcriptional regulation of pluripotent stem cells PTK6 Expression Neddylation Pexophagy Regulation of PD-L1(CD274) transcription
Drugs		None	Vadadustat Belzutifan
Diseases		None	Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS		Body mass index ( 26426971 ) Congenital left-sided heart lesions ( 26965164 ) Cutaneous squamous cell carcinoma ( 32041948 ) Estimated glomerular filtration rate ( 31451708 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Fasting glucose ( 34059833 ) Hip circumference adjusted for BMI ( 34021172 ) Melanoma ( 21983785 28212542 ) Metabolic syndrome ( 31589552 ) Platelet count ( 32888494 ) Rhegmatogenous retinal detachment ( 23585552 ) Tea consumption ( 31046077 ) Urate levels ( 23263486 )	Appendicular lean mass ( 33097823 ) Birth weight ( 27680694 31043758 ) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872 ) Craniofacial microsomia ( 26853712 ) Diisocyanate-induced asthma ( 25918132 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Facial morphology ( 29921221 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 30188897 ) High altitude adaptation ( 28373541 ) Offspring birth weight ( 31043758 ) Oxygenated hemoglobin levels ( 30188897 ) P wave duration ( 28794112 ) Peak velocity of the mitral A-wave ( 28394258 ) PR interval ( 32439900 ) Refractive error ( 32231278 ) Renal cell carcinoma ( 21131975 31231134 25826619 )
Interacting Genes		78 interacting genes: ADH5 AHR AHRR AIP AKT1 ARL14 ARNT2 BECN1 BRCA1 CALCOCO1 CASP3 CASP9 CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CLOCK CSNK2A1 DIABLO EP300 EPAS1 EPHA2 ERBB2 ESR1 FGFR4 FZR1 GLIS1 GLIS2 GMNN GTF2F1 GTF2F2 HEY1 HEY2 HGF HIF1A HIF3A HNF4A IRAK4 KPNA1 KPNA3 KPNA5 KPNA6 LATS2 LSM8 MAP2K5 MAPK14 MTA3 MYC NCOA1 NCOA2 NCOA7 NCOR2 NF2 NPAS2 NPAS4 PDGFRA PML PTGES3 RAF1 RELA SENP6 SIM1 SIM2 SMAD9 SP1 STK11 STRBP TACC3 TEAD2 TGM2 TNFAIP1 TRIP11 TUBB2A UBE2I	41 interacting genes: APC ARNT ARNT2 BATF BATF2 BATF3 BBS1 BBS2 BBS4 BMAL1 BMAL2 CHD4 DBP DDIT3 EGLN1 EGLN2 EGLN3 EIF3E EP300 ESR1 ETV4 EWSR1 F12 JUN KLHL20 KPNA1 KPNA3 KPNA5 KPNA6 KPNB1 MAX MEF2C NDN PRKD1 SMAD3 SPP1 STAT5A TERF2IP UBE3B USP20 VHL
Entrez ID		405	2034
HPRD ID		00524	06787
Ensembl ID		ENSG00000143437	ENSG00000116016
Uniprot IDs		A8K6P0 B0AZM1 P27540 Q53F30	B3KW07 Q99814
PDB IDs		1X0O 2A24 2B02 2HV1 2K7S 3F1N 3F1O 3F1P 3H7W 3H82 4EQ1 4GHI 4GS9 4H6J 4LPZ 4PKY 4XT2 5TBM 5UFP 5V0L 6CZW 6D09 6D0B 6D0C 6X21 6X28 6X2H 6X37 6X3D 8CK3 8CK4 8CK8 8G4A 8XS6 8XS7 8XS8 8XS9 8XSA 8XSB	1P97 2A24 3F1N 3F1O 3F1P 3H7W 3H82 4GHI 4GS9 4PKY 4XT2 5KIZ 5TBM 5UFP 6BVB 6CZW 6D09 6D0B 6D0C 6I7Q 6I7R 6X21 6X28 6X2H 6X37 6X3D 7Q5V 7Q5X 7UJV 8CK3 8CK4 8CK8 8Q5S 8Q64 8Q6D 8Q6E 8RUT 8RUV 8RUZ 8RV1
GO Terms Enriched among Interactors		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Dimerization Activity Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Positive Regulation Of Metabolic Process Transcription Regulator Complex Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Regulation Of Gene Expression Rhythmic Process Developmental Process Cytoplasm Cell Differentiation Regulation Of Cell Cycle Signal Transduction Animal Organ Development Transcription By RNA Polymerase II Regulation Of Apoptotic Process Positive Regulation Of Cell Population Proliferation DNA-templated Transcription Regulation Of Programmed Cell Death DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Cytosol DNA-binding Transcription Factor Activity Regulation Of Intracellular Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cellular Developmental Process	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II NLS-dependent Protein Nuclear Import Complex Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Nucleus RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleoplasm Nuclear Import Signal Receptor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nuclear Localization Sequence Binding Aryl Hydrocarbon Receptor Complex NLS-bearing Protein Import Into Nucleus Transcription Regulator Complex DNA-binding Transcription Factor Binding Peptidyl-proline 4-dioxygenase Activity Integrated Stress Response Signaling Cellular Response To Stress Hypoxia-inducible Factor-proline Dioxygenase Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Sequence-specific Double-stranded DNA Binding Protein Localization To Organelle Response To Stress Response To Hypoxia BBSome Response To Decreased Oxygen Levels Aryl Hydrocarbon Receptor Binding Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Response To Oxygen Levels Cytoplasm