ARNT and SIM1

Number of citations: 0 (PubMedID 9020169)
Data Source: HPRD (two hybrid, in vitro, in vivo)

		ARNT	SIM1
Name		aryl hydrocarbon receptor nuclear translocator	SIM bHLH transcription factor 1
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Body Aryl Hydrocarbon Receptor Complex Nuclear Aryl Hydrocarbon Receptor Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Aryl Hydrocarbon Receptor Binding Protein Homodimerization Activity Sequence-specific DNA Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity Protein Dimerization Activity
	Biological Process	Response To Hypoxia Embryonic Placenta Development Positive Regulation Of Endothelial Cell Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Vascular Endothelial Growth Factor Production Cell Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Sumoylation Cellular Response To Oxidative Stress Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hormone Biosynthetic Process Negative Regulation Of Inflammatory Response Intestinal Epithelial Structure Maintenance	Ureteric Bud Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Cell Differentiation System Development
Pathways		Regulation of gene expression by Hypoxia-inducible Factor PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling NPAS4 regulates expression of target genes NPAS4 regulates expression of target genes	None
GWAS		Body mass index ( 26426971 ) Congenital left-sided heart lesions ( 26965164 ) Cutaneous squamous cell carcinoma ( 32041948 ) Estimated glomerular filtration rate ( 31451708 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Fasting glucose ( 34059833 ) Hip circumference adjusted for BMI ( 34021172 ) Melanoma ( 21983785 28212542 ) Metabolic syndrome ( 31589552 ) Platelet count ( 32888494 ) Rhegmatogenous retinal detachment ( 23585552 ) Tea consumption ( 31046077 ) Urate levels ( 23263486 )	Body size at age 10 ( 32376654 ) Creatinine levels ( 29403010 ) Erectile dysfunction ( 30297428 ) Estimated glomerular filtration rate ( 31152163 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Gait speed in old age ( 28077804 ) Glomerular filtration rate ( 29403010 ) Iris color (L* coordinate) ( 30895295 ) Irritable mood ( 29500382 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Major depressive disorder ( 27479909 ) Menarche (age at onset) ( 25231870 ) Neurociticism ( 29500382 ) Neuroticism ( 29255261 ) Sociability score ( 34054130 ) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971 )
Interacting Genes		78 interacting genes: ADH5 AHR AHRR AIP AKT1 ARL14 ARNT2 BECN1 BRCA1 CALCOCO1 CASP3 CASP9 CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CLOCK CSNK2A1 DIABLO EP300 EPAS1 EPHA2 ERBB2 ESR1 FGFR4 FZR1 GLIS1 GLIS2 GMNN GTF2F1 GTF2F2 HEY1 HEY2 HGF HIF1A HIF3A HNF4A IRAK4 KPNA1 KPNA3 KPNA5 KPNA6 LATS2 LSM8 MAP2K5 MAPK14 MTA3 MYC NCOA1 NCOA2 NCOA7 NCOR2 NF2 NPAS2 NPAS4 PDGFRA PML PTGES3 RAF1 RELA SENP6 SIM1 SIM2 SMAD9 SP1 STK11 STRBP TACC3 TEAD2 TGM2 TNFAIP1 TRIP11 TUBB2A UBE2I	3 interacting genes: ARNT ARNT2 HSP90AA1
Entrez ID		405	6492
HPRD ID		00524	07049
Ensembl ID		ENSG00000143437	ENSG00000112246
Uniprot IDs		A8K6P0 B0AZM1 P27540 Q53F30	P81133
PDB IDs		1X0O 2A24 2B02 2HV1 2K7S 3F1N 3F1O 3F1P 3H7W 3H82 4EQ1 4GHI 4GS9 4H6J 4LPZ 4PKY 4XT2 5TBM 5UFP 5V0L 6CZW 6D09 6D0B 6D0C 6X21 6X28 6X2H 6X37 6X3D 8CK3 8CK4 8CK8 8G4A 8XS6 8XS7 8XS8 8XS9 8XSA 8XSB	Not available
GO Terms Enriched among Interactors		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Dimerization Activity Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Positive Regulation Of Metabolic Process Transcription Regulator Complex Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Regulation Of Gene Expression Rhythmic Process Developmental Process Cytoplasm Cell Differentiation Regulation Of Cell Cycle Signal Transduction Animal Organ Development Transcription By RNA Polymerase II Regulation Of Apoptotic Process Positive Regulation Of Cell Population Proliferation DNA-templated Transcription Regulation Of Programmed Cell Death DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Cytosol DNA-binding Transcription Factor Activity Regulation Of Intracellular Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cellular Developmental Process	Aryl Hydrocarbon Receptor Binding Aryl Hydrocarbon Receptor Complex Positive Regulation Of Erythrocyte Differentiation Response To Hypoxia Response To Decreased Oxygen Levels Response To Oxygen Levels Regulation Of Erythrocyte Differentiation Positive Regulation Of Catabolic Process Sequence-specific Double-stranded DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Myeloid Cell Differentiation DNA-binding Transcription Factor Activity CTP Binding DATP Binding Nuclear Aryl Hydrocarbon Receptor Complex Positive Regulation Of Muscle Atrophy Initiation Of Primordial Ovarian Follicle Growth Cellular Response To Corticosterone Stimulus Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Protein Dimerization Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Response To Water-immersion Restraint Stress Rho GDP-dissociation Inhibitor Binding Regulation Of Myeloid Cell Differentiation Chromatin Cellular Response To Oxidative Stress DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Mitochondrial Transcription Factor Activity Antral Ovarian Follicle Growth Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Response To Stress Regulation Of Post-translational Protein Modification Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Sperm Mitochondrial Sheath Regulation Of Muscle System Process Telomerase Holoenzyme Complex Assembly Cellular Response To Chemical Stress Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Intestinal Epithelial Structure Maintenance RNA Polymerase II Transcription Repressor Complex Response To Xenobiotic Stimulus Mitochondrial Transcription Chaperone-mediated Autophagy Nitric-oxide Synthase Regulator Activity