ARNT and NPAS4

Number of citations of the paper that reports this interaction (PMID 14701734)
30

Data Source:
HPRD (two hybrid)

		ARNT	NPAS4
Gene Name		aryl hydrocarbon receptor nuclear translocator	neuronal PAS domain protein 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Factor Complex	Nucleus Transcription Factor Complex
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Aryl Hydrocarbon Receptor Activity Protein Binding Transcription Factor Binding Aryl Hydrocarbon Receptor Binding Enhancer Binding Sequence-specific DNA Binding Protein Heterodimerization Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Signal Transducer Activity Protein Heterodimerization Activity
	Biological Process	Response To Hypoxia Embryonic Placenta Development Positive Regulation Of Endothelial Cell Proliferation Transcription, DNA-templated Positive Regulation Vascular Endothelial Growth Factor Production Cell Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Sumoylation MRNA Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hormone Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia	Transcription, DNA-templated Signal Transduction Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Regulation of gene expression by Hypoxia-inducible Factor
Drugs
Diseases
GWAS		Melanoma ( 21983785) Rhegmatogenous retinal detachment ( 23585552) Urate levels ( 23263486)	Bipolar disorder ( 21926972)
Protein-Protein Interactions		37 interactors: ADH5 AHR AHRR AIP ARNT2 BRCA1 CSNK2A1 DIABLO EP300 EPAS1 ESR1 GMNN GTF2F1 GTF2F2 HEY1 HEY2 HIF1A IRAK4 LSM8 MTA3 NCOA1 NCOA2 NCOA7 NCOR2 NPAS4 PML PTGES3 SENP6 SIM1 SIM2 SMAD9 SP1 SRC STRBP TNFAIP1 TRIP11 UBE2I	3 interactors: ARNT ARNT2 ARNTL
Entrez ID		405	266743
HPRD ID		00524	12260
Ensembl ID		ENSG00000143437	ENSG00000174576
Uniprot IDs		A8K6P0 B0AZM1 F8WAP6 P27540	Q8IUM7
PDB IDs		1D7G 1X0O 2A24 2ARN 2B02 2HV1 2K7S 3F1N 3F1O 3F1P 3H7W 3H82 4EQ1 4GHI 4GS9 4H6J
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Gene Expression Regulation Of Transcription, DNA-templated RNA Metabolic Process Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Rhythmic Process Signal Transduction Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Cellular Metabolic Process Tube Development Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Developmental Process Involved In Reproduction Signaling Intracellular Receptor Signaling Pathway Embryonic Placenta Development Cell Communication Reproductive Structure Development Response To Stimulus Negative Regulation Of Biosynthetic Process Reproductive System Development Regulation Of Cellular Process Embryo Development Organ Development Single Organism Reproductive Process Multicellular Organismal Development	Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Cellular Response To Oxidative Stress Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Response To Hypoxia Oxidative Stress-induced Premature Senescence Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Skeletal Muscle Cell Differentiation Stress-induced Premature Senescence Response To Oxidative Stress Transcription, DNA-templated Negative Regulation Of Glucocorticoid Receptor Signaling Pathway RNA Biosynthetic Process Response To Redox State Positive Regulation Of Cellular Metabolic Process Regulation Of Type B Pancreatic Cell Development In Utero Embryonic Development Positive Regulation Of Hormone Biosynthetic Process MRNA Transcription From RNA Polymerase II Promoter Positive Regulation Of Glycolytic Process Positive Regulation Of Protein Sumoylation Regulation Of Skeletal Muscle Cell Differentiation Positive Regulation Of Circadian Rhythm MRNA Transcription Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Regulation Of Protein Sumoylation RNA Metabolic Process Positive Regulation Of Erythrocyte Differentiation Regulation Of Cellular Senescence Regulation Of Hair Cycle Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Stress Gene Expression Cellular Senescence Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Protein Import Into Nucleus, Translocation Regulation Of Glycolytic Process Regulation Of Hormone Biosynthetic Process Positive Regulation Of Cell Proliferation Cellular Macromolecule Biosynthetic Process Negative Regulation Of TOR Signaling Positive Regulation Of Cell Differentiation Macromolecule Biosynthetic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Tagcloud ?		belong bhlh cobalt confers dimerizes frame helix heterodimer heterodimeric heterologous hif1alpha hif2alpha hif3alpha hifs hrd1 hre hypoxia identity pas prototype reading recognizes resultant shares superfamily tacgtg tension thymus transfections	accumbens acetylated acetyltransferase addiction atf2 causal cck cholecystokinin corticotropin crf deacetylases fosb h3k18ac h3k9ac h4k5 h4k8 hat hats hdac1 hdac2 hdacs injection longterm meth methamphetamine nac neuropsychiatric psychostimulants releasing
Tagcloud (Difference) ?		belong bhlh cobalt confers dimerizes frame helix heterodimer heterodimeric heterologous hif1alpha hif2alpha hif3alpha hifs hrd1 hre hypoxia identity pas prototype reading recognizes resultant shares superfamily tacgtg tension thymus transfections	accumbens acetylated acetyltransferase addiction atf2 causal cck cholecystokinin corticotropin crf deacetylases fosb h3k18ac h3k9ac h4k5 h4k8 hat hats hdac1 hdac2 hdacs injection longterm meth methamphetamine nac neuropsychiatric psychostimulants releasing
Tagcloud (Intersection) ?