ARNT and LATS2

Number of citations of the paper that reports this interaction (PubMedID 28205554)
55

Data Source:
BioGRID (fluorescent resonance energy transfer)

		ARNT	LATS2
Description		aryl hydrocarbon receptor nuclear translocator	large tumor suppressor kinase 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Body Aryl Hydrocarbon Receptor Complex Nuclear Aryl Hydrocarbon Receptor Complex RNA Polymerase II Transcription Regulator Complex	Spindle Pole Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Centriolar Satellite
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Aryl Hydrocarbon Receptor Binding Protein Homodimerization Activity Sequence-specific DNA Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Response To Hypoxia Embryonic Placenta Development Positive Regulation Of Endothelial Cell Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Vascular Endothelial Growth Factor Production Cell Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Sumoylation Cellular Response To Oxidative Stress Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hormone Biosynthetic Process Negative Regulation Of Inflammatory Response Intestinal Epithelial Structure Maintenance	G1/S Transition Of Mitotic Cell Cycle Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Protein Phosphorylation Intracellular Protein Localization Hormone-mediated Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Keratinocyte Differentiation Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Mitotic Cell Cycle Phase Transition Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cell Division Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Pathways		Regulation of gene expression by Hypoxia-inducible Factor PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling NPAS4 regulates expression of target genes NPAS4 regulates expression of target genes	Signaling by Hippo
Drugs
Diseases
GWAS		Body mass index ( 26426971) Congenital left-sided heart lesions ( 26965164) Cutaneous squamous cell carcinoma ( 32041948) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Fasting glucose ( 34059833) Hip circumference adjusted for BMI ( 34021172) Melanoma ( 21983785 28212542) Metabolic syndrome ( 31589552) Platelet count ( 32888494) Rhegmatogenous retinal detachment ( 23585552) Tea consumption ( 31046077) Urate levels ( 23263486)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference adjusted for BMI ( 34021172) Refractive error ( 32231278)
Interacting Genes		78 interacting genes: ADH5 AHR AHRR AIP AKT1 ARL14 ARNT2 BECN1 BRCA1 CALCOCO1 CASP3 CASP9 CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CLOCK CSNK2A1 DIABLO EP300 EPAS1 EPHA2 ERBB2 ESR1 FGFR4 FZR1 GLIS1 GLIS2 GMNN GTF2F1 GTF2F2 HEY1 HEY2 HGF HIF1A HIF3A HNF4A IRAK4 KPNA1 KPNA3 KPNA5 KPNA6 LATS2 LSM8 MAP2K5 MAPK14 MTA3 MYC NCOA1 NCOA2 NCOA7 NCOR2 NF2 NPAS2 NPAS4 PDGFRA PML PTGES3 RAF1 RELA SENP6 SIM1 SIM2 SMAD9 SP1 STK11 STRBP TACC3 TEAD2 TGM2 TNFAIP1 TRIP11 TUBB2A UBE2I	70 interacting genes: ABL1 AJUBA AKT1 ARAF ARNT AURKA AURKB BECN1 BRAF CBLC CCND2 CCNE1 CD44 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDKN2B CDKN2C CHEK1 CHEK2 CTNNB1 DCAF1 DYRK1A EPHA2 ERBB2 EZH2 FGFR4 FHL3 FZR1 GLIS1 GLIS2 GRAP2 GRM1 HGF HIF1A KAT2A KDELR2 KIF23 MAP2K3 MAP2K5 MAPK14 MDM4 MET MOB3A MOB3B MOB3C MOB4 MYC NFIC PDGFRA RAF1 RASSF1 RELA SIAH2 SMAD2 SNAI1 SRC STK11 STK3 SUZ12 TAFAZZIN TEAD2 TP53 TSC1 WWTR1 YAP1 YWHAG YWHAZ
Entrez ID		405	26524
HPRD ID		00524	07277
Ensembl ID		ENSG00000143437	ENSG00000150457
Uniprot IDs		A8K6P0 B0AZM1 P27540 Q53F30	Q9NRM7
PDB IDs		1X0O 2A24 2B02 2HV1 2K7S 3F1N 3F1O 3F1P 3H7W 3H82 4EQ1 4GHI 4GS9 4H6J 4LPZ 4PKY 4XT2 5TBM 5UFP 5V0L 6CZW 6D09 6D0B 6D0C 6X21 6X28 6X2H 6X37 6X3D 8CK3 8CK4 8CK8 8G4A 8XS6 8XS7 8XS8 8XS9 8XSA 8XSB	4ZRI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Dimerization Activity Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Positive Regulation Of Metabolic Process Transcription Regulator Complex Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Regulation Of Gene Expression Rhythmic Process Developmental Process Cytoplasm Cell Differentiation Regulation Of Cell Cycle Signal Transduction Animal Organ Development Transcription By RNA Polymerase II Regulation Of Apoptotic Process Positive Regulation Of Cell Population Proliferation DNA-templated Transcription Regulation Of Programmed Cell Death DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Cytosol DNA-binding Transcription Factor Activity Regulation Of Intracellular Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cellular Developmental Process	Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Kinase Activity Protein Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Intracellular Signal Transduction Signal Transduction Regulation Of Cell Population Proliferation Animal Organ Development Negative Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Response To Growth Factor Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Protein Serine/threonine Kinase Activity Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Apoptotic Process Protein Serine Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Phase Transition Nucleus Regulation Of Programmed Cell Death Intracellular Signaling Cassette Positive Regulation Of Signal Transduction Regulation Of Metabolic Process Protein Phosphorylation Protein Modification Process Regulation Of Protein Modification Process Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Population Proliferation Cell Differentiation Regulation Of Mitotic Cell Cycle Cellular Response To Stress Regulation Of Macromolecule Metabolic Process Transferase Activity Phosphorylation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process
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