LRPAP1 and RALGDS

Number of citations of the paper that reports this interaction (PubMedID 10783161)
33

Data Source:
BioGRID (two hybrid)

		LRPAP1	RALGDS
Description		LDL receptor related protein associated protein 1	ral guanine nucleotide dissociation stimulator
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GO Annotations	Cellular Component	Extracellular Region Endosome Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Golgi Lumen Cis-Golgi Network Plasma Membrane Cell Surface Endomembrane System Endosome Lumen Vesicle Rough Endoplasmic Reticulum Lumen	Nucleus Cytoplasm Cytosol Plasma Membrane Brush Border
	Molecular Function	Amyloid-beta Binding Signaling Receptor Binding Protein Binding Heparin Binding Lipase Binding Receptor Ligand Activity Receptor Antagonist Activity Low-density Lipoprotein Particle Receptor Binding Very-low-density Lipoprotein Particle Receptor Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity
	Biological Process	Negative Regulation Of Receptor Internalization Signal Transduction Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Regulation Of Receptor-mediated Endocytosis Amyloid-beta Clearance By Transcytosis Extracellular Negative Regulation Of Signal Transduction Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Clearance	Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction
Pathways			p38MAPK events p38MAPK events RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Cholesterol, total ( 24097068 25961943) Fibrinogen ( 23969696) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Total cholesterol levels ( 28334899) Triglyceride levels ( 28334899) Triglycerides ( 24097068 25961943) Tuberculosis ( 29036319)	Blood protein levels in cardiovascular risk ( 28369058)
Interacting Genes		21 interacting genes: ASPH ETV7 IFNAR1 LDLR LRP1 LRP1B LRP2 LRP8 MAPK1 MAPK3 POLA2 PPM1G RAF1 RALGDS RANBP2 RTN4 SNCA SORL1 SORT1 TTC3 VLDLR	26 interacting genes: AFDN ARRB1 ARRB2 CD68 CNKSR1 CYSRT1 HOXA1 HRAS KRAS KRTAP10-8 LRPAP1 MAPK3 MRAS NF2 PDPK1 RAP1A RAP1B RAP1GAP RAP2A RAP2B RAPGEF2 RIN1 RIT1 RIT2 RRAS RRAS2
Entrez ID		4043	5900
HPRD ID		00082	03371
Ensembl ID		ENSG00000163956	ENSG00000160271
Uniprot IDs		P30533	Q12967 Q8N4Y1
PDB IDs		1LRE 1NRE 1OP1 1OV2 2FCW 2FTU 2FYL 2P01 2P03	1RAX 2B3A 2RGF 3KH0
Enriched GO Terms of Interacting Partners?		Low-density Lipoprotein Particle Receptor Activity Endocytosis Import Into Cell Receptor-mediated Endocytosis Receptor Complex Very-low-density Lipoprotein Particle Receptor Activity Positive Regulation Of Lysosomal Protein Catabolic Process Clathrin-coated Pit Cargo Receptor Activity Vesicle-mediated Transport Positive Regulation Of Protein Catabolic Process In The Vacuole ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Regulation Of Lysosomal Protein Catabolic Process Calcium Ion Binding Apolipoprotein Binding Pseudopodium Reelin Receptor Activity Schwann Cell Development Retinoid Metabolic Process Early Endosome Diterpenoid Metabolic Process Protein Transport Face Development Plasma Membrane ERBB2 Signaling Pathway Amyloid-beta Metabolic Process Amyloid-beta Binding Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Amyloid-beta Clearance Interleukin-34-mediated Signaling Pathway Terpenoid Metabolic Process Positive Regulation Of Macrophage Migration Thyroid Gland Development Isoprenoid Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Golgi Inheritance Establishment Of Protein Localization Positive Regulation Of Protein Localization Golgi Apparatus Positive Regulation Of Defense Response Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Regulation Of Intracellular Transport Regulation Of Neuroinflammatory Response Intracellular Protein Localization Regulation Of Macrophage Migration Anatomical Structure Morphogenesis Regulation Of Cellular Localization	GDP Binding G Protein Activity Small GTPase-mediated Signal Transduction Intracellular Signaling Cassette GTPase Activity Ras Protein Signal Transduction Rap Protein Signal Transduction GTP Binding Intracellular Signal Transduction Plasma Membrane Signal Transduction Regulation Of MAPK Cascade Establishment Of Endothelial Barrier Regulation Of Vesicle-mediated Transport Endothelial Cell Development Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cellular Component Organization Epithelial Cell Development Positive Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Regulation Of Microvillus Assembly Nucleotide Binding Positive Regulation Of Vasculogenesis Regulation Of Cell Migration MAPK Cascade Establishment Of Endothelial Intestinal Barrier Regulation Of Cell Motility Regulation Of Vasculogenesis Angiotensin Receptor Binding Regulation Of Locomotion Cell Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Endocytosis Schwann Cell Migration Modulation Of Chemical Synaptic Transmission Regulation Of Signal Transduction Membrane Hydrolase Activity Actin Cytoskeleton Organization Positive Regulation Of Cell Projection Organization Positive Regulation Of Cell Migration Positive Regulation Of Microvillus Assembly Positive Regulation Of Cell Motility Regulation Of Cell Projection Assembly Positive Regulation Of Locomotion Regulation Of Cellular Component Organization Anchoring Junction Actin Filament-based Process Desensitization Of G Protein-coupled Receptor Signaling Pathway
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