LRPAP1 and VLDLR

Number of citations of the paper that reports this interaction (PubMedID 7592875)
0

Data Source:
HPRD (in vivo, in vitro)

		LRPAP1	VLDLR
Description		LDL receptor related protein associated protein 1	very low density lipoprotein receptor
Image
GO Annotations	Cellular Component	Extracellular Region Endosome Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Golgi Lumen Cis-Golgi Network Plasma Membrane Cell Surface Endomembrane System Endosome Lumen Vesicle Rough Endoplasmic Reticulum Lumen	Extracellular Space Lysosomal Membrane Plasma Membrane Clathrin-coated Pit Membrane Very-low-density Lipoprotein Particle Receptor Complex Synapse Glutamatergic Synapse
	Molecular Function	Amyloid-beta Binding Signaling Receptor Binding Protein Binding Heparin Binding Lipase Binding Receptor Ligand Activity Receptor Antagonist Activity Low-density Lipoprotein Particle Receptor Binding Very-low-density Lipoprotein Particle Receptor Binding	Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Very-low-density Lipoprotein Particle Binding Cargo Receptor Activity Reelin Receptor Activity Calcium-dependent Protein Binding
	Biological Process	Negative Regulation Of Receptor Internalization Signal Transduction Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Regulation Of Receptor-mediated Endocytosis Amyloid-beta Clearance By Transcytosis Extracellular Negative Regulation Of Signal Transduction Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Clearance	Lipid Metabolic Process Lipid Transport Endocytosis Receptor-mediated Endocytosis Signal Transduction Nervous System Development Memory Steroid Metabolic Process Cholesterol Metabolic Process Ventral Spinal Cord Development Glycoprotein Transport Very-low-density Lipoprotein Particle Clearance Reelin-mediated Signaling Pathway Dendrite Morphogenesis Regulation Of Synapse Assembly Positive Regulation Of Dendrite Development
Pathways			Reelin signalling pathway VLDLR internalisation and degradation VLDL clearance
Drugs			Lauric acid
Diseases
GWAS		Cholesterol, total ( 24097068 25961943) Fibrinogen ( 23969696) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Total cholesterol levels ( 28334899) Triglyceride levels ( 28334899) Triglycerides ( 24097068 25961943) Tuberculosis ( 29036319)	Alzheimer's disease (age of onset) ( 22005931) Apolipoprotein B levels ( 32203549) Cholesterol, total ( 24097068) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Gambling ( 22780124) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Inflammatory biomarkers (multivariate analysis) ( 33110245) LDL cholesterol ( 30275531 24097068) LDL cholesterol levels ( 28334899 32203549) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Systolic blood pressure ( 26969751) Total cholesterol levels ( 30275531) Vascular endothelial growth factor levels ( 21757650 31217265 27989323 26910538) White blood cell count ( 32888494) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621)
Interacting Genes		21 interacting genes: ASPH ETV7 IFNAR1 LDLR LRP1 LRP1B LRP2 LRP8 MAPK1 MAPK3 POLA2 PPM1G RAF1 RALGDS RANBP2 RTN4 SNCA SORL1 SORT1 TTC3 VLDLR	12 interacting genes: APOE CD36 CLU DAB1 DYRK1A ITSN1 LPL LRPAP1 MYLIP RELN SNX17 ZSCAN12
Entrez ID		4043	7436
HPRD ID		00082	01895
Ensembl ID		ENSG00000163956	ENSG00000147852
Uniprot IDs		P30533	A0A7P0T897 A0A7P0T8N9 A0A7P0T9P7 P98155 Q5VVF5
PDB IDs		1LRE 1NRE 1OP1 1OV2 2FCW 2FTU 2FYL 2P01 2P03	1V9U 3DPR 6BYV 8IHP 8UA4 8UA8 8UFB 8UFC 8X0K 8X0L 8X0M 8XI4 8XI5 8YS2 8YS4 8YVZ 8YW0 8YW1 8YW2
Enriched GO Terms of Interacting Partners?		Low-density Lipoprotein Particle Receptor Activity Endocytosis Import Into Cell Receptor-mediated Endocytosis Receptor Complex Very-low-density Lipoprotein Particle Receptor Activity Positive Regulation Of Lysosomal Protein Catabolic Process Clathrin-coated Pit Cargo Receptor Activity Vesicle-mediated Transport Positive Regulation Of Protein Catabolic Process In The Vacuole ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Regulation Of Lysosomal Protein Catabolic Process Calcium Ion Binding Apolipoprotein Binding Pseudopodium Reelin Receptor Activity Schwann Cell Development Retinoid Metabolic Process Early Endosome Diterpenoid Metabolic Process Protein Transport Face Development Plasma Membrane ERBB2 Signaling Pathway Amyloid-beta Metabolic Process Amyloid-beta Binding Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Amyloid-beta Clearance Interleukin-34-mediated Signaling Pathway Terpenoid Metabolic Process Positive Regulation Of Macrophage Migration Thyroid Gland Development Isoprenoid Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Golgi Inheritance Establishment Of Protein Localization Positive Regulation Of Protein Localization Golgi Apparatus Positive Regulation Of Defense Response Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Regulation Of Intracellular Transport Regulation Of Neuroinflammatory Response Intracellular Protein Localization Regulation Of Macrophage Migration Anatomical Structure Morphogenesis Regulation Of Cellular Localization	Very-low-density Lipoprotein Particle Receptor Binding Low-density Lipoprotein Particle Receptor Binding Regulation Of Neurofibrillary Tangle Assembly Lipoprotein Particle Binding Receptor Ligand Activity Regulation Of Endocytosis Regulation Of Inclusion Body Assembly Amyloid-beta Binding Regulation Of Amyloid-beta Clearance Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Cellular Component Organization Amyloid-beta Clearance Plasma Lipoprotein Particle Clearance Regulation Of Vesicle-mediated Transport Lateral Motor Column Neuron Migration Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Dendritic Spine Development Low-density Lipoprotein Particle Mediated Signaling Spinal Cord Motor Neuron Migration Positive Regulation Of Nitric Oxide Metabolic Process Tau Protein Binding Very-low-density Lipoprotein Particle Clearance Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Endocytosis NMDA Glutamate Receptor Clustering Positive Regulation Of Inclusion Body Assembly Regulation Of Amyloid-beta Formation Negative Regulation Of Cellular Component Organization Regulation Of Amyloid Precursor Protein Catabolic Process Signaling Receptor Binding Regulation Of Dendritic Spine Development Receptor-mediated Endocytosis Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Protein Import Positive Regulation Of Cholesterol Storage Regulation Of Nitric Oxide Biosynthetic Process Very-low-density Lipoprotein Particle Remodeling Positive Regulation Of Amyloid-beta Clearance Cholesterol Catabolic Process Regulation Of Nitric Oxide Metabolic Process Ventral Spinal Cord Development Cholesterol Transport Nitric Oxide-cGMP-mediated Signaling Triglyceride-rich Lipoprotein Particle Remodeling Sterol Transport Regulation Of Amide Metabolic Process Reelin-mediated Signaling Pathway Neurotransmitter-gated Ion Channel Clustering Cholesterol Homeostasis Chylomicron
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