LRPAP1 and TTC3

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		LRPAP1	TTC3
Description		LDL receptor related protein associated protein 1	tetratricopeptide repeat domain 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endosome Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Golgi Lumen Cis-Golgi Network Plasma Membrane Cell Surface Endomembrane System Endosome Lumen Vesicle Rough Endoplasmic Reticulum Lumen	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Amyloid-beta Binding Signaling Receptor Binding Protein Binding Heparin Binding Lipase Binding Receptor Ligand Activity Receptor Antagonist Activity Low-density Lipoprotein Particle Receptor Binding Very-low-density Lipoprotein Particle Receptor Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Receptor Internalization Signal Transduction Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Regulation Of Receptor-mediated Endocytosis Amyloid-beta Clearance By Transcytosis Extracellular Negative Regulation Of Signal Transduction Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Clearance	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K48-linked Ubiquitination
Pathways
Drugs
Diseases
GWAS		Cholesterol, total ( 24097068 25961943) Fibrinogen ( 23969696) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Total cholesterol levels ( 28334899) Triglyceride levels ( 28334899) Triglycerides ( 24097068 25961943) Tuberculosis ( 29036319)	Eye color traits ( 20463881)
Interacting Genes		21 interacting genes: ASPH ETV7 IFNAR1 LDLR LRP1 LRP1B LRP2 LRP8 MAPK1 MAPK3 POLA2 PPM1G RAF1 RALGDS RANBP2 RTN4 SNCA SORL1 SORT1 TTC3 VLDLR	72 interacting genes: AKAP17A AKT1 APP ARID1A ATF7IP ATP2A2 ATP6V0A1 BLOC1S2 CADPS CADPS2 CEP290 CHUK CKAP2 CKAP5 COG4 COPS5 DAAM2 DLEU7 DSP DST EIF4G2 ETS2 EXOC4 FBXO7 FMNL2 FUT8 HARS1 HERC2 HSPB1 IFIT5 JADE2 JAK1 KANSL2 LCOR LRPAP1 MDH1 MIR7-1 MORF4L1 NR1D2 NR1H2 NUFIP1 PAX6 PBX2 PKNOX1 POLG PPFIBP1 PRKDC PSMD7 PSME1 RAI14 SH3BP5 SHROOM2 SMARCA4 SPARCL1 SPTAN1 SPTBN1 STXBP1 TAF1 THOP1 TJP1 TRAF6 TTN UBE2D2 UBE2E3 UBE3A UBR4 USP28 VHL WAC WHAMM XRN2 YWHAE
Entrez ID		4043	7267
HPRD ID		00082	03773
Ensembl ID		ENSG00000163956	ENSG00000182670
Uniprot IDs		P30533	H7BZ57 P53804
PDB IDs		1LRE 1NRE 1OP1 1OV2 2FCW 2FTU 2FYL 2P01 2P03
Enriched GO Terms of Interacting Partners?		Low-density Lipoprotein Particle Receptor Activity Endocytosis Import Into Cell Receptor-mediated Endocytosis Receptor Complex Very-low-density Lipoprotein Particle Receptor Activity Positive Regulation Of Lysosomal Protein Catabolic Process Clathrin-coated Pit Cargo Receptor Activity Vesicle-mediated Transport Positive Regulation Of Protein Catabolic Process In The Vacuole ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Regulation Of Lysosomal Protein Catabolic Process Calcium Ion Binding Apolipoprotein Binding Pseudopodium Reelin Receptor Activity Schwann Cell Development Retinoid Metabolic Process Early Endosome Diterpenoid Metabolic Process Protein Transport Face Development Plasma Membrane ERBB2 Signaling Pathway Amyloid-beta Metabolic Process Amyloid-beta Binding Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Amyloid-beta Clearance Interleukin-34-mediated Signaling Pathway Terpenoid Metabolic Process Positive Regulation Of Macrophage Migration Thyroid Gland Development Isoprenoid Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Golgi Inheritance Establishment Of Protein Localization Positive Regulation Of Protein Localization Golgi Apparatus Positive Regulation Of Defense Response Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Regulation Of Intracellular Transport Regulation Of Neuroinflammatory Response Intracellular Protein Localization Regulation Of Macrophage Migration Anatomical Structure Morphogenesis Regulation Of Cellular Localization	Positive Regulation Of RNA Biosynthetic Process Protein-containing Complex Cytosol Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Protein Polyubiquitination Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Biosynthetic Process Dense Core Granule Exocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle Establishment Of Vesicle Localization Protein K48-linked Ubiquitination Vesicle Localization Ubiquitin-protein Transferase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Calmodulin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein K11-linked Ubiquitination Organelle Localization Toll-like Receptor 4 Signaling Pathway Regulation Of Autophagy Regulation Of Gene Expression Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Cell Cycle Protein Modification Process Regulation Of Metabolic Process Enzyme Binding Intracellular Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Cadherin Binding Positive Regulation Of Macromolecule Metabolic Process Protein Localization To Cell-cell Junction Secretory Granule Localization Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Cellular Response To Stress Nucleoplasm Positive Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Cell Cortex Regulation Of RNA Metabolic Process Golgi To Plasma Membrane Transport Ubiquitin-dependent Protein Catabolic Process Proteasome Complex
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