LRPAP1 and POLA2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LRPAP1	POLA2
Description		LDL receptor related protein associated protein 1	DNA polymerase alpha 2, accessory subunit
Image
GO Annotations	Cellular Component	Extracellular Region Endosome Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Golgi Lumen Cis-Golgi Network Plasma Membrane Cell Surface Endomembrane System Endosome Lumen Vesicle Rough Endoplasmic Reticulum Lumen	Nucleus Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol Ciliary Basal Body
	Molecular Function	Amyloid-beta Binding Signaling Receptor Binding Protein Binding Heparin Binding Lipase Binding Receptor Ligand Activity Receptor Antagonist Activity Low-density Lipoprotein Particle Receptor Binding Very-low-density Lipoprotein Particle Receptor Binding	DNA Binding Protein Binding
	Biological Process	Negative Regulation Of Receptor Internalization Signal Transduction Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Regulation Of Receptor-mediated Endocytosis Amyloid-beta Clearance By Transcytosis Extracellular Negative Regulation Of Signal Transduction Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Clearance	DNA Replication DNA Replication, Synthesis Of Primer DNA Replication Initiation Protein Import Into Nucleus
Pathways			Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis
Drugs			Dacarbazine
Diseases
GWAS		Cholesterol, total ( 24097068 25961943) Fibrinogen ( 23969696) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Total cholesterol levels ( 28334899) Triglyceride levels ( 28334899) Triglycerides ( 24097068 25961943) Tuberculosis ( 29036319)	Acne (severe) ( 24927181) Appendicular lean mass ( 33097823) Hip circumference adjusted for BMI ( 34021172) Serum uric acid levels ( 32514006)
Interacting Genes		21 interacting genes: ASPH ETV7 IFNAR1 LDLR LRP1 LRP1B LRP2 LRP8 MAPK1 MAPK3 POLA2 PPM1G RAF1 RALGDS RANBP2 RTN4 SNCA SORL1 SORT1 TTC3 VLDLR	33 interacting genes: AKTIP APP ASCC2 ATP5F1C CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SETDB1 SNU13 STK40 ULK2 XPNPEP1
Entrez ID		4043	23649
HPRD ID		00082	10160
Ensembl ID		ENSG00000163956	ENSG00000014138
Uniprot IDs		P30533	A0A9L9PY44 H0YDR7 Q14181
PDB IDs		1LRE 1NRE 1OP1 1OV2 2FCW 2FTU 2FYL 2P01 2P03	2KEB 4E2I 4Y97 5EXR 7OPL 7U5C 8B9D 8D0B 8D0K 8D9D 8QJ7 8VY3 9C8V
Enriched GO Terms of Interacting Partners?		Low-density Lipoprotein Particle Receptor Activity Endocytosis Import Into Cell Receptor-mediated Endocytosis Receptor Complex Very-low-density Lipoprotein Particle Receptor Activity Positive Regulation Of Lysosomal Protein Catabolic Process Clathrin-coated Pit Cargo Receptor Activity Vesicle-mediated Transport Positive Regulation Of Protein Catabolic Process In The Vacuole ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Regulation Of Lysosomal Protein Catabolic Process Calcium Ion Binding Apolipoprotein Binding Pseudopodium Reelin Receptor Activity Schwann Cell Development Retinoid Metabolic Process Early Endosome Diterpenoid Metabolic Process Protein Transport Face Development Plasma Membrane ERBB2 Signaling Pathway Amyloid-beta Metabolic Process Amyloid-beta Binding Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Amyloid-beta Clearance Interleukin-34-mediated Signaling Pathway Terpenoid Metabolic Process Positive Regulation Of Macrophage Migration Thyroid Gland Development Isoprenoid Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Golgi Inheritance Establishment Of Protein Localization Positive Regulation Of Protein Localization Golgi Apparatus Positive Regulation Of Defense Response Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Regulation Of Intracellular Transport Regulation Of Neuroinflammatory Response Intracellular Protein Localization Regulation Of Macrophage Migration Anatomical Structure Morphogenesis Regulation Of Cellular Localization	DNA Replication, Synthesis Of Primer Regulation Of Phosphorus Metabolic Process Nucleic Acid Metabolic Process Collateral Sprouting RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Macromolecule Metabolic Process Alpha DNA Polymerase:primase Complex Regulation Of Glycolytic Process
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