APOB and MTTP

Number of citations: 0 (PubMedID 9915855)
Data Source: HPRD (two hybrid, in vivo)

		APOB	MTTP
Name		apolipoprotein B	microsomal triglyceride transfer protein
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Clathrin-coated Endocytic Vesicle Membrane Endosome Lumen Mature Chylomicron Chylomicron Remnant Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Chylomicron Neuronal Cell Body Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Endoplasmic Reticulum Exit Site Endocytic Vesicle Lumen	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Cytosol Basolateral Plasma Membrane Brush Border Membrane Microvillus Membrane Vesicle Receptor Complex
	Molecular Function	Lipid Transporter Activity Protein Binding Phospholipid Binding Heparin Binding Lipase Binding Receptor Ligand Activity Low-density Lipoprotein Particle Receptor Binding Cholesterol Transfer Activity	Lipid Transporter Activity Protein Binding Phospholipid Transporter Activity Lipid Binding Apolipoprotein Binding Protein-containing Complex Binding Protein Heterodimerization Activity Phospholipid Transfer Activity Phosphatidylcholine Transfer Activity Cholesterol Transfer Activity Triglyceride Transfer Activity Ceramide 1-phosphate Transfer Activity Phosphatidylethanolamine Transfer Activity
	Biological Process	In Utero Embryonic Development Lipid Metabolic Process Triglyceride Mobilization Lipid Transport Signal Transduction Spermatogenesis Nervous System Development Steroid Metabolic Process Cholesterol Metabolic Process Fertilization Response To Virus Post-embryonic Development Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Positive Regulation Of Cholesterol Storage Lipid Catabolic Process Triglyceride Catabolic Process Cholesterol Transport Flagellated Sperm Motility Cholesterol Efflux Low-density Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Assembly Low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Lipoprotein Catabolic Process Cholesterol Homeostasis Lipoprotein Transport Regulation Of Cholesterol Biosynthetic Process Artery Morphogenesis Establishment Of Localization In Cell Cellular Response To Lipoprotein Particle Stimulus Cellular Response To Amyloid-beta	Lipid Metabolic Process Triglyceride Metabolic Process Lipid Transport Circadian Rhythm Protein Secretion Phospholipid Transport Sterol Transport Triglyceride Transport Low-density Lipoprotein Particle Remodeling Plasma Lipoprotein Particle Assembly Chylomicron Assembly Very-low-density Lipoprotein Particle Assembly Lipoprotein Metabolic Process Cholesterol Homeostasis Lipoprotein Transport Response To Calcium Ion Establishment Of Localization In Cell Intermembrane Lipid Transfer Ceramide 1-phosphate Transport
Pathways		Cell surface interactions at the vascular wall Scavenging by Class B Receptors Scavenging by Class B Receptors Scavenging by Class A Receptors Scavenging by Class A Receptors Scavenging by Class F Receptors Scavenging by Class F Receptors Scavenging by Class H Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Platelet sensitization by LDL Regulation of TLR by endogenous ligand Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance Chylomicron clearance LDL clearance LDL clearance LDL remodeling VLDL clearance VLDL clearance Heme signaling Retinoid metabolism and transport Retinoid metabolism and transport	VLDL assembly Chylomicron assembly LDL remodeling
Drugs		Zinc chloride Zinc sulfate, unspecified form	Hesperetin Implitapide SLx-4090 Lomitapide
Diseases		Hypercholesterolemia, autosomal dominant; Hyperlipoproteinemia, type IIa	Abetalipoproteinemia; Bassen-Kornzweig Disease
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717 ) Apolipoprotein A1 levels ( 32203549 ) Apolipoprotein B levels ( 32203549 ) Barrett's esophagus or Esophageal adenocarcinoma ( 31527586 ) Binge eating behaviour and bipolar disorder ( 24882193 ) Cardiovascular disease risk factors ( 21943158 ) Carotid intima media thickness ( 30510157 ) Cholesterol, total ( 19060911 20686565 24097068 25961943 26582766 ) Coronary artery disease ( 32469254 33020668 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Erectile dysfunction and prostate cancer treatment ( 20932654 ) Gastroesophageal reflux disease ( 31527586 ) HDL cholesterol ( 19060911 20686565 20864672 25961943 30275531 ) HDL cholesterol levels ( 32203549 ) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535 ) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535 ) High density lipoprotein cholesterol levels ( 33339817 ) Hypertriglyceridemia ( 20657596 ) LDL (oxidized) ( 23247145 ) LDL cholesterol ( 18193043 18193044 18262040 19060906 19060910 19060911 20686565 20864672 21059979 21347282 23726366 24097068 24507774 25961943 26582766 26780889 30275531 ) LDL cholesterol levels ( 17463246 26690388 28334899 30698716 31087446 32203549 32759990 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels in HIV infection ( 33109212 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535 ) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535 ) Lipid metabolism phenotypes ( 19936222 ) Lipid or lipoprotein levels ( 23696881 ) Lipoprotein (a) levels ( 33730874 ) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302 ) Low density lipoprotein cholesterol levels ( 33339817 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Metabolic syndrome ( 22399527 31589552 ) Metabolic traits ( 19060910 ) Metabolite levels ( 22916037 ) Non-HDL cholesterol levels ( 32902719 ) Oxidized LDL cholesterol levels ( 31150472 ) Pancreatic cancer ( 30206226 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 ) Pulse pressure ( 30224653 ) Red cell distribution width ( 32888494 ) Response to statin therapy ( 20339536 ) Serum alkaline phosphatase levels ( 33547301 ) Serum metabolite levels ( 31636271 33031748 ) Serum metabolite levels (CMS) ( 31636271 ) Total cholesterol levels ( 26690388 28334899 30275531 30718733 31087446 32902719 33339817 ) Triglyceride levels ( 29403010 32154731 32203549 33339817 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535 ) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535 ) Triglycerides ( 18193044 19060906 19060911 20686565 20864672 25961943 26160806 )	Alanine aminotransferase levels ( 34315874 ) Aspartate aminotransferase levels ( 34315874 ) Celiac disease ( 23936387 ) HDL cholesterol ( 30275531 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Percent liver fat ( 34128465 ) Regular attendance at a pub or social club ( 29970889 ) Triglyceride levels ( 32203549 )
Interacting Genes		25 interacting genes: AKT2 APOA1 ARFGAP1 BGN CALR CANX CD36 HSP90AA1 HSP90B1 HSPA1A HSPA5 HSPA8 LDLR LIPC LRP2 LRP6 MDM2 MTTP PDIA4 PPIB PRDX4 SEC61A2 SEC61B SMAD3 TREM2	2 interacting genes: APOB HSP90B1
Entrez ID		338	4547
HPRD ID		00133	01144
Ensembl ID		ENSG00000084674	ENSG00000138823
Uniprot IDs		A0AAG2UUW0 P04114 Q59HB3 Q7Z7Q0	B7Z7X3 E9PBP6 P55157
PDB IDs		9BD1 9BD8 9BDE 9BDT 9COO 9E9R 9EA7 9EAG	8EOJ
GO Terms Enriched among Interactors		Unfolded Protein Binding Protein Folding Intracellular Protein Localization Endoplasmic Reticulum Lumen Lipoprotein Particle Binding Protein Folding Chaperone Establishment Of Protein Localization Protein Transport Regulation Of Protein Stability ATP-dependent Protein Folding Chaperone Protein Folding In Endoplasmic Reticulum Low-density Lipoprotein Particle Receptor Activity Catabolic Process Melanosome Protein Catabolic Process Low-density Lipoprotein Particle Binding Endocytic Vesicle Lumen Response To Endoplasmic Reticulum Stress Protein Stabilization Amyloid-beta Metabolic Process Endoplasmic Reticulum Amyloid-beta Clearance Cholesterol Import Plasma Lipoprotein Particle Clearance Protein Refolding Macromolecule Catabolic Process Sterol Transport Amyloid-beta Clearance By Cellular Catabolic Process Post-translational Protein Targeting To Membrane, Translocation Ubiquitin Protein Ligase Binding ERAD Pathway Cellular Response To Lipoprotein Particle Stimulus High-density Lipoprotein Particle Binding Endoplasmic Reticulum Chaperone Complex Positive Regulation Of Protein Catabolic Process Cellular Response To Stress Regulation Of Protein Catabolic Process Brush Border Membrane Regulation Of Defense Response Protein Metabolic Process Response To Hormone Apolipoprotein Binding Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Cellular Response To Oxygen-containing Compound Heat Shock Protein Binding Cell Surface Regulation Of Programmed Cell Death Cholesterol Transport Negative Regulation Of Programmed Cell Death	Endocytic Vesicle Lumen Smooth Endoplasmic Reticulum Low-density Lipoprotein Particle Receptor Binding Mature Chylomicron Response To Virus Triglyceride Mobilization Positive Regulation Of Cholesterol Storage Very-low-density Lipoprotein Particle Assembly Lipoprotein Biosynthetic Process Extracellular Exosome Lipoprotein Catabolic Process Chylomicron Remnant Intermediate-density Lipoprotein Particle Lipase Binding Endoplasmic Reticulum Lumen Sequestering Of Calcium Ion Actin Rod Assembly Sarcoplasmic Reticulum Lumen Endoplasmic Reticulum Chaperone Complex Positive Regulation Of Toll-like Receptor Signaling Pathway Sperm Plasma Membrane Protein Folding In Endoplasmic Reticulum Cellular Response To Manganese Ion Interleukin-23-mediated Signaling Pathway Growth Hormone Receptor Binding Interleukin-10-mediated Signaling Pathway Interleukin-12 Receptor Complex Positive Regulation Of Natural Killer Cell Proliferation Extrinsic Component Of Plasma Membrane Positive Regulation Of NK T Cell Proliferation Interleukin-12-mediated Signaling Pathway Interleukin-23 Receptor Complex Type III Interferon-mediated Signaling Pathway Positive Regulation Of NK T Cell Activation Lipoprotein Transport Low-density Lipoprotein Particle Remodeling Chylomicron Low-density Lipoprotein Particle Low-density Lipoprotein Particle Clearance Retrograde Protein Transport, ER To Cytosol Cellular Response To ATP Response To Manganese Ion Type II Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of Natural Killer Cell Proliferation Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Triglyceride Catabolic Process Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of Macrophage Derived Foam Cell Differentiation Very-low-density Lipoprotein Particle