DAB2 and SGIP1

Number of citations of the paper that reports this interaction (PubMedID 27237791)
54

Data Source:
BioGRID (pull down)

		DAB2	SGIP1
Description		DAB adaptor protein 2	SH3GL interacting endocytic adaptor 1
Image
GO Annotations	Cellular Component	Fibrillar Center Cytoplasm Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit Focal Adhesion Membrane Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane AP-2 Adaptor Complex Clathrin-coated Vesicle Presynapse
	Molecular Function	Protein Binding Clathrin Adaptor Activity Cargo Receptor Activity SMAD Binding Low-density Lipoprotein Particle Receptor Binding	Protein Binding Phospholipid Binding Microtubule Binding Tubulin Binding SH3 Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endocytosis Receptor-mediated Endocytosis Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Neuron Projection Development Protein Transport Wnt Signaling Pathway Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Leading Edge Cell Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Clathrin Coat Assembly Response To Steroid Hormone Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Response To Salt Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Aldosterone Secretion	Response To Dietary Excess Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis Energy Homeostasis Positive Regulation Of Feeding Behavior
Pathways		Gap junction degradation Formation of annular gap junctions Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29083406) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301 29403010) Birth weight ( 31043758) Chronic kidney disease ( 20383146 31152163) Creatinine levels ( 31015462) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31451708 31152163 30604766 31015462) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) HDL cholesterol levels ( 32203549) Health literacy ( 31250787) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Non-albumin protein levels ( 29403010) Pancreatic cancer ( 22158540) Premature menopause in childhood cancer survivors ( 29432556) Self-reported allergy ( 23817569) Systemic lupus erythematosus ( 19838195) Urate levels ( 23263486) Waist-hip ratio ( 28552196)	Automobile speeding propensity ( 30643258) Cerebellum white matter volume ( 31530798) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Chronotype ( 30696823) Crohn's disease ( 28067908) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908) Menopause (age at onset) ( 23307926) Presence of antiphospholipid antibodies ( 23509613) Pulse pressure ( 30224653 30578418) Systolic blood pressure ( 30578418) TPE interval (resting) ( 32386560) Ulcerative colitis ( 28067908)
Interacting Genes		40 interacting genes: AP2M1 APLP1 APLP2 APP ATXN1L AXIN1 CDC16 CDK1 CSK DAB2IP DIP2A DVL1 DVL3 FCHO1 FCHO2 FGR GRB2 INPP5D ITGB3 ITGB5 ITSN1 LDLR LRP1 LRP2 LRP8 MIB1 MYO6 NECAP1 PIN1 PRKCB PRKCD PRKCG SGIP1 SMAD2 SMAD3 SMURF2 SRC SUMO2 TGFBR1 TGFBR2	2 interacting genes: APP DAB2
Entrez ID		1601	84251
HPRD ID		03139	10910
Ensembl ID		ENSG00000153071	ENSG00000118473
Uniprot IDs		B2RAW0 P98082	A0A804HHV6 A0A804HI01 A0A804HJG4 A0A804HJX5 B7Z691 Q9BQI5
PDB IDs		2LSW 6O5O 6OVF	5AWR 5AWS 5AWT 5AWU 6A9Y
Enriched GO Terms of Interacting Partners?		Clathrin-coated Pit Endocytosis Import Into Cell Plasma Membrane Cell Surface Receptor Signaling Pathway Anatomical Structure Morphogenesis Receptor Complex Signal Transduction Regulation Of Endocytosis Regulation Of Vesicle-mediated Transport Receptor-mediated Endocytosis Vesicle-mediated Transport Regulation Of Cellular Component Organization Intracellular Signal Transduction Regulation Of Protein Catabolic Process Regulation Of Signaling Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cellular Component Organization Positive Regulation Of Developmental Process Response To Growth Factor Regulation Of Cell Communication Clathrin-dependent Endocytosis Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Cellular Response To Growth Factor Stimulus Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Tube Morphogenesis Positive Regulation Of Protein Catabolic Process Regulation Of Transport Low-density Lipoprotein Particle Receptor Activity Membrane I-SMAD Binding Cellular Response To Oxygen-containing Compound Presynaptic Endocytosis Regulation Of Cellular Response To Growth Factor Stimulus Vesicle-mediated Transport In Synapse Regulation Of Protein Localization Immune Response-activating Cell Surface Receptor Signaling Pathway SMAD Binding Cytosol Positive Regulation Of Lysosomal Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Neuron Projection Morphogenesis Enzyme-linked Receptor Protein Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Cell Projection Morphogenesis	Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Proteolysis Acetylcholine Receptor Activator Activity Negative Regulation Of Canonical Wnt Signaling Pathway Amyloid-beta Complex PTB Domain Binding Protein Homooligomerization Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Protein Catabolic Process Endosome To Plasma Membrane Transport Vesicle Protein Tetramerization Negative Regulation Of Protein Localization Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Endocytosis Growth Cone Filopodium Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Clathrin-coated Pit Positive Regulation Of Small Molecule Metabolic Process Protein-containing Complex Assembly Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Aldosterone Biosynthetic Process Leading Edge Cell Differentiation Positive Regulation Of Aldosterone Secretion Positive Regulation Of Ribosome Biogenesis Protein-containing Complex Organization Regulation Of Canonical Wnt Signaling Pathway Protein Complex Oligomerization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Translational Elongation Intermediate-density Lipoprotein Particle Regulation Of ERK1 And ERK2 Cascade
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