LIFR and POU2F1

Number of citations of the paper that reports this interaction (PMID 10383413)
9

Data Source:
HPRD (in vitro)

		LIFR	POU2F1
Gene Name		leukemia inhibitory factor receptor alpha	POU class 2 homeobox 1
Image
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Receptor Complex Extracellular Vesicular Exosome	Nucleus Nucleoplasm Transcription Factor Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Growth Factor Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Response To Cytokine Oncostatin-M-mediated Signaling Pathway Leukemia Inhibitory Factor Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway	Transcription From RNA Polymerase III Promoter Gene Expression Olfactory Placode Formation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Lens Induction In Camera-type Eye
Pathways			RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase III Abortive And Retractive Initiation
Drugs
Diseases
GWAS			Liver enzyme levels ( 18940312)
Protein-Protein Interactions		12 interactors: CNTF CNTFR CTF1 IL31RA IL6ST LIF MAPK1 OSM PLCG1 POU2F1 PTPN11 PTPN6	50 interactors: AES APP AR BARD1 BRCA1 CEBPE CREB1 EPRS ESR1 FDXR HCFC1 HMGA1 HMGB2 HNF1A HOXB13 HOXC9 IRF9 LIFR MNAT1 MSX1 NCOR2 NFYA NPAT NR3C1 PARP1 PBX1 PGR PKNOX1 PLK3 POGZ POU2AF1 PRKACA PRKDC RARA RELA RXRA SNAPC4 SOX2 SP1 SP4 STAT5A STAT5B TBP THRA TLE4 TLX2 TNF TXNRD1 VDR XRCC6
Entrez ID		3977	5451
HPRD ID		01048	01250
Ensembl ID		ENSG00000113594	ENSG00000143190
Uniprot IDs		A8K1Z4 P42702	J3KP77 P14859
PDB IDs		3E0G	1CQT 1E3O 1GT0 1HF0 1O4X 1OCT 1POG 1POU
Enriched GO Terms of Interacting Partners?		Cellular Response To Cytokine Stimulus Response To Cytokine Cytokine-mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation JAK-STAT Cascade Regulation Of Protein Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Protein Phosphorylation Leukemia Inhibitory Factor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Signal Transduction Ciliary Neurotrophic Factor-mediated Signaling Pathway Regulation Of Phosphorylation System Development Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Multicellular Organismal Development Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Anatomical Structure Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of JAK-STAT Cascade Positive Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Developmental Process Regulation Of Cellular Protein Metabolic Process Signaling Cell Communication Regulation Of Protein Metabolic Process Regulation Of JAK-STAT Cascade Nervous System Development Cell Differentiation Abortive Mitotic Cell Cycle Regulation Of MAPK Cascade Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Signal Transduction Regulation Of Signal Transduction Regulation Of Immune System Process Organ Development Oncostatin-M-mediated Signaling Pathway	Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Gland Development Negative Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Organ Development Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Response To Hormone DNA-templated Transcription, Initiation Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Response To Steroid Hormone Organ Morphogenesis Reproductive Process Hormone-mediated Signaling Pathway Anatomical Structure Morphogenesis Intracellular Receptor Signaling Pathway Multicellular Organismal Development System Development
Tagcloud ?		box chimeric coexpression consensus constructs contained converges dominant entire gp130 jak lacking mapk maximal maximally mitogen motif polypeptide polypeptides positions putative ras shp2 similarly stimulate stimulation tyk tyr y118f	build built compendium connected controlling databases delineate deoxyribonuclease encode experimentally footprinting gata3 hnf1b hypersensitivity klf4 locations matrices motifs orthologs rarb runx2 rxra silico smad3 sp1 sp3 umod upstream uromodulin
Tagcloud (Difference) ?		box chimeric coexpression consensus constructs contained converges dominant entire gp130 jak lacking mapk maximal maximally mitogen motif polypeptide polypeptides positions putative ras shp2 similarly stimulate stimulation tyk tyr y118f	build built compendium connected controlling databases delineate deoxyribonuclease encode experimentally footprinting gata3 hnf1b hypersensitivity klf4 locations matrices motifs orthologs rarb runx2 rxra silico smad3 sp1 sp3 umod upstream uromodulin
Tagcloud (Intersection) ?