LIFR and CTF1

Number of citations of the paper that reports this interaction (PMID 11834704)
8

Data Source:
HPRD (in vivo)

		LIFR	CTF1
Gene Name		leukemia inhibitory factor receptor alpha	cardiotrophin 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Receptor Complex Extracellular Vesicular Exosome	Extracellular Region Extracellular Space
	Molecular Function	Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Growth Factor Binding	Cytokine Activity Leukemia Inhibitory Factor Receptor Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Response To Cytokine Oncostatin-M-mediated Signaling Pathway Leukemia Inhibitory Factor Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway	Cell-cell Signaling Nervous System Development Muscle Organ Development Cell Proliferation Positive Regulation Of Cell Proliferation Neuron Development Leukemia Inhibitory Factor Signaling Pathway
Pathways
Drugs
Diseases
GWAS			Triglycerides ( 20686565)
Protein-Protein Interactions		12 interactors: CNTF CNTFR CTF1 IL31RA IL6ST LIF MAPK1 OSM PLCG1 POU2F1 PTPN11 PTPN6	5 interactors: APP EP300 IL6ST LIFR MAGEA6
Entrez ID		3977	1489
HPRD ID		01048	02699
Ensembl ID		ENSG00000113594	ENSG00000150281
Uniprot IDs		A8K1Z4 P42702	Q16619
PDB IDs		3E0G
Enriched GO Terms of Interacting Partners?		Cellular Response To Cytokine Stimulus Response To Cytokine Cytokine-mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation JAK-STAT Cascade Regulation Of Protein Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Protein Phosphorylation Leukemia Inhibitory Factor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Signal Transduction Ciliary Neurotrophic Factor-mediated Signaling Pathway Regulation Of Phosphorylation System Development Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Multicellular Organismal Development Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Anatomical Structure Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of JAK-STAT Cascade Positive Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Developmental Process Regulation Of Cellular Protein Metabolic Process Signaling Cell Communication Regulation Of Protein Metabolic Process Regulation Of JAK-STAT Cascade Nervous System Development Cell Differentiation Abortive Mitotic Cell Cycle Regulation Of MAPK Cascade Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Signal Transduction Regulation Of Signal Transduction Regulation Of Immune System Process Organ Development Oncostatin-M-mediated Signaling Pathway	Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Histone H2B Acetylation Interleukin-11-mediated Signaling Pathway Notch Signaling Pathway Regulation Of Protein Binding Synaptic Growth At Neuromuscular Junction Interleukin-27-mediated Signaling Pathway Collateral Sprouting In Absence Of Injury N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Interleukin-6-mediated Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Tubulin Deacetylation Regulation Of Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Cell Surface Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Neuron Remodeling Positive Regulation By Host Of Viral Transcription Positive Regulation Of Astrocyte Differentiation Positive Regulation Of Cytokine Production N-terminal Protein Amino Acid Acetylation Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Cellular Amino Acid Metabolic Process Interleukin-6-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Cardiac Muscle Hypertrophy Cellular Copper Ion Homeostasis Regulation Of Cellular Ketone Metabolic Process Cellular Response To Organic Substance Regulation Of Androgen Receptor Signaling Pathway Copper Ion Homeostasis Suckling Behavior Regulation Of Cytokine Production Regulation Of Cellular Protein Metabolic Process Viral Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Interleukin-6 Cellular Response To Cytokine Stimulus N-terminal Protein Amino Acid Modification Positive Regulation Of Acute Inflammatory Response Regulation Of Astrocyte Differentiation
Tagcloud ?		box chimeric coexpression consensus constructs contained converges dominant entire gp130 jak lacking mapk maximal maximally mitogen motif polypeptide polypeptides positions putative ras shp2 similarly stimulate stimulation tyk tyr y118f	colonization ctf2 deltactf1 deltactf1deltactf2 deltactf2 existence fungal fungus fusarium gly inoculation lip1 lip2 lip22 lip3 lip5 lipase lipases lipolytic lycopersici mutants oxysporum pathogenicity pentapeptide severely silico thirteen tomato virulence
Tagcloud (Difference) ?		box chimeric coexpression consensus constructs contained converges dominant entire gp130 jak lacking mapk maximal maximally mitogen motif polypeptide polypeptides positions putative ras shp2 similarly stimulate stimulation tyk tyr y118f	colonization ctf2 deltactf1 deltactf1deltactf2 deltactf2 existence fungal fungus fusarium gly inoculation lip1 lip2 lip22 lip3 lip5 lipase lipases lipolytic lycopersici mutants oxysporum pathogenicity pentapeptide severely silico thirteen tomato virulence
Tagcloud (Intersection) ?