LIFR and IL31RA

Number of citations of the paper that reports this interaction (PMID 15184896)
67

Data Source:
HPRD (in vivo)

		LIFR	IL31RA
Gene Name		leukemia inhibitory factor receptor alpha	interleukin 31 receptor A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Receptor Complex Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Growth Factor Binding	Transcription Coactivator Activity Cytokine Receptor Activity Protein Kinase Binding Cytokine Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Response To Cytokine Oncostatin-M-mediated Signaling Pathway Leukemia Inhibitory Factor Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway	MAPK Cascade Defense Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway JAK-STAT Cascade Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Monocyte Differentiation Macrophage Differentiation Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Homeostatic Process Negative Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS			Crohn's disease ( 23128233)
Protein-Protein Interactions		12 interactors: CNTF CNTFR CTF1 IL31RA IL6ST LIF MAPK1 OSM PLCG1 POU2F1 PTPN11 PTPN6	2 interactors: IL6ST LIFR
Entrez ID		3977	133396
HPRD ID		01048	17145
Ensembl ID		ENSG00000113594	ENSG00000164509
Uniprot IDs		A8K1Z4 P42702	B4DNJ2 J3KNB6 Q8NI17
PDB IDs		3E0G
Enriched GO Terms of Interacting Partners?		Cellular Response To Cytokine Stimulus Response To Cytokine Cytokine-mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation JAK-STAT Cascade Regulation Of Protein Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Protein Phosphorylation Leukemia Inhibitory Factor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Signal Transduction Ciliary Neurotrophic Factor-mediated Signaling Pathway Regulation Of Phosphorylation System Development Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Multicellular Organismal Development Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Anatomical Structure Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of JAK-STAT Cascade Positive Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Developmental Process Regulation Of Cellular Protein Metabolic Process Signaling Cell Communication Regulation Of Protein Metabolic Process Regulation Of JAK-STAT Cascade Nervous System Development Cell Differentiation Abortive Mitotic Cell Cycle Regulation Of MAPK Cascade Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Signal Transduction Regulation Of Signal Transduction Regulation Of Immune System Process Organ Development Oncostatin-M-mediated Signaling Pathway	Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Interleukin-11-mediated Signaling Pathway Interleukin-27-mediated Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Astrocyte Differentiation Response To Cytokine Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Interleukin-6-mediated Signaling Pathway Positive Regulation Of Cell Proliferation Positive Regulation Of Cardiac Muscle Hypertrophy Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Interleukin-6 Positive Regulation Of Acute Inflammatory Response Regulation Of Astrocyte Differentiation Regulation Of Cardiac Muscle Hypertrophy Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Response To Interleukin-6 Positive Regulation Vascular Endothelial Growth Factor Production Negative Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Glial Cell Differentiation Negative Regulation Of Response To Cytokine Stimulus Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Cell Proliferation Positive Regulation Of Gliogenesis Glycogen Metabolic Process Positive Regulation Of JAK-STAT Cascade Regulation Of Notch Signaling Pathway Regulation Of Acute Inflammatory Response Positive Regulation Of Osteoblast Differentiation Cellular Response To Organic Substance Regulation Of Glial Cell Differentiation Polysaccharide Metabolic Process Positive Regulation Of T Cell Proliferation Regulation Of JAK-STAT Cascade Positive Regulation Of Inflammatory Response Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Ossification Regulation Of Gliogenesis Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Osteoblast Differentiation Response To Organic Substance Energy Reserve Metabolic Process
Tagcloud ?		box chimeric coexpression consensus constructs contained converges dominant entire gp130 jak lacking mapk maximal maximally mitogen motif polypeptide polypeptides positions putative ras shp2 similarly stimulate stimulation tyk tyr y118f	ag490 bms chx concert cox2 cycloheximide extrinsic fgf13 hgf hsf igfbp4 igfbp6 igfl2 il1a il1b il1r1 il21r il6 iotal17beta iotal18 iotal19 iotal28beta mmp12 ptgs2 qrt rho stat3 substantially trail
Tagcloud (Difference) ?		box chimeric coexpression consensus constructs contained converges dominant entire gp130 jak lacking mapk maximal maximally mitogen motif polypeptide polypeptides positions putative ras shp2 similarly stimulate stimulation tyk tyr y118f	ag490 bms chx concert cox2 cycloheximide extrinsic fgf13 hgf hsf igfbp4 igfbp6 igfl2 il1a il1b il1r1 il21r il6 iotal17beta iotal18 iotal19 iotal28beta mmp12 ptgs2 qrt rho stat3 substantially trail
Tagcloud (Intersection) ?