LIFR and LIF

Number of citations of the paper that reports this interaction (PMID 12601009)
2

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		LIFR	LIF
Gene Name		leukemia inhibitory factor receptor alpha	leukemia inhibitory factor
Image
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Receptor Complex Extracellular Vesicular Exosome	Extracellular Space Cytoplasm
	Molecular Function	Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Growth Factor Binding	RNA Polymerase II Transcription Factor Recruiting Transcription Factor Activity Receptor Binding Cytokine Activity Leukemia Inhibitory Factor Receptor Binding Growth Factor Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Response To Cytokine Oncostatin-M-mediated Signaling Pathway Leukemia Inhibitory Factor Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway	Blood Vessel Remodeling Transcription From RNA Polymerase II Promoter Immune Response Multicellular Organismal Development Embryo Implantation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Stem Cell Maintenance Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of MAPK Cascade Positive Regulation Of Macrophage Differentiation Negative Regulation Of Meiotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Decidualization Negative Regulation Of Hormone Secretion Lung Alveolus Development Muscle Organ Morphogenesis Neuron Development Positive Regulation Of Astrocyte Differentiation Leukemia Inhibitory Factor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Lung Vasculature Development Lung Lobe Morphogenesis Trophoblast Giant Cell Differentiation Spongiotrophoblast Differentiation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Histone H3-K27 Acetylation
Pathways
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Inflammatory bowel disease (early onset) ( 19915574) Nephropathy ( 21399633)
Protein-Protein Interactions		12 interactors: CNTF CNTFR CTF1 IL31RA IL6ST LIF MAPK1 OSM PLCG1 POU2F1 PTPN11 PTPN6	2 interactors: IL6ST LIFR
Entrez ID		3977	3976
HPRD ID		01048	08869
Ensembl ID		ENSG00000113594	ENSG00000128342
Uniprot IDs		A8K1Z4 P42702	P15018
PDB IDs		3E0G	1EMR 1PVH 2Q7N
Enriched GO Terms of Interacting Partners?		Cellular Response To Cytokine Stimulus Response To Cytokine Cytokine-mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation JAK-STAT Cascade Regulation Of Protein Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Protein Phosphorylation Leukemia Inhibitory Factor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Signal Transduction Ciliary Neurotrophic Factor-mediated Signaling Pathway Regulation Of Phosphorylation System Development Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Multicellular Organismal Development Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Anatomical Structure Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of JAK-STAT Cascade Positive Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Developmental Process Regulation Of Cellular Protein Metabolic Process Signaling Cell Communication Regulation Of Protein Metabolic Process Regulation Of JAK-STAT Cascade Nervous System Development Cell Differentiation Abortive Mitotic Cell Cycle Regulation Of MAPK Cascade Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Signal Transduction Regulation Of Signal Transduction Regulation Of Immune System Process Organ Development Oncostatin-M-mediated Signaling Pathway	Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Interleukin-11-mediated Signaling Pathway Interleukin-27-mediated Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Astrocyte Differentiation Response To Cytokine Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Interleukin-6-mediated Signaling Pathway Positive Regulation Of Cell Proliferation Positive Regulation Of Cardiac Muscle Hypertrophy Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Interleukin-6 Positive Regulation Of Acute Inflammatory Response Regulation Of Astrocyte Differentiation Regulation Of Cardiac Muscle Hypertrophy Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Response To Interleukin-6 Positive Regulation Vascular Endothelial Growth Factor Production Negative Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Glial Cell Differentiation Negative Regulation Of Response To Cytokine Stimulus Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Cell Proliferation Positive Regulation Of Gliogenesis Glycogen Metabolic Process Positive Regulation Of JAK-STAT Cascade Regulation Of Notch Signaling Pathway Regulation Of Acute Inflammatory Response Positive Regulation Of Osteoblast Differentiation Cellular Response To Organic Substance Regulation Of Glial Cell Differentiation Polysaccharide Metabolic Process Positive Regulation Of T Cell Proliferation Regulation Of JAK-STAT Cascade Positive Regulation Of Inflammatory Response Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Ossification Regulation Of Gliogenesis Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Osteoblast Differentiation Response To Organic Substance Energy Reserve Metabolic Process
Tagcloud ?		box chimeric coexpression consensus constructs contained converges dominant entire gp130 jak lacking mapk maximal maximally mitogen motif polypeptide polypeptides positions putative ras shp2 similarly stimulate stimulation tyk tyr y118f	cis1 cis3 ctll2 cytokine fcgammari forced fos hel ifnbeta ifngamma il6 ilf jab jak jh1 kinetics m1 modulators ones parental possess possesses sh2 slower structurally supporting unlike ut weaker
Tagcloud (Difference) ?		box chimeric coexpression consensus constructs contained converges dominant entire gp130 lacking mapk maximal maximally mitogen motif polypeptide polypeptides positions putative ras shp2 similarly stimulate stimulation tyk tyr y118f	cis1 cis3 ctll2 cytokine fcgammari forced fos hel ifnbeta ifngamma il6 ilf jab jh1 kinetics m1 modulators ones parental possess possesses sh2 slower structurally supporting unlike ut weaker
Tagcloud (Intersection) ?		jak