LIFR and CNTFR

Number of citations of the paper that reports this interaction (PMID 11285233)
14

Data Source:
HPRD (in vitro)

		LIFR	CNTFR
Gene Name		leukemia inhibitory factor receptor alpha	ciliary neurotrophic factor receptor
Image
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Receptor Complex Extracellular Vesicular Exosome	Extrinsic Component Of Membrane Anchored Component Of Membrane Ciliary Neurotrophic Factor Receptor Complex CNTFR-CLCF1 Complex
	Molecular Function	Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Growth Factor Binding	Ciliary Neurotrophic Factor Receptor Activity Receptor Binding Cytokine Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Response To Cytokine Oncostatin-M-mediated Signaling Pathway Leukemia Inhibitory Factor Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway	Suckling Behavior Brainstem Development Signal Transduction Nervous System Development Sex Differentiation Positive Regulation Of Cell Proliferation Negative Regulation Of Neuron Apoptotic Process Skeletal Muscle Organ Development Ciliary Neurotrophic Factor-mediated Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: CNTF CNTFR CTF1 IL31RA IL6ST LIF MAPK1 OSM PLCG1 POU2F1 PTPN11 PTPN6	9 interactors: APPBP2 CLCF1 CNTF CRLF1 HN1L IL6ST KRTAP4-12 LIFR PLSCR1
Entrez ID		3977	1271
HPRD ID		01048	00348
Ensembl ID		ENSG00000113594	ENSG00000122756
Uniprot IDs		A8K1Z4 P42702	P26992
PDB IDs		3E0G	1UC6
Enriched GO Terms of Interacting Partners?		Cellular Response To Cytokine Stimulus Response To Cytokine Cytokine-mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation JAK-STAT Cascade Regulation Of Protein Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Protein Phosphorylation Leukemia Inhibitory Factor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Signal Transduction Ciliary Neurotrophic Factor-mediated Signaling Pathway Regulation Of Phosphorylation System Development Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Multicellular Organismal Development Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Anatomical Structure Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of JAK-STAT Cascade Positive Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Developmental Process Regulation Of Cellular Protein Metabolic Process Signaling Cell Communication Regulation Of Protein Metabolic Process Regulation Of JAK-STAT Cascade Nervous System Development Cell Differentiation Abortive Mitotic Cell Cycle Regulation Of MAPK Cascade Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Signal Transduction Regulation Of Signal Transduction Regulation Of Immune System Process Organ Development Oncostatin-M-mediated Signaling Pathway See more	Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of JAK-STAT Cascade Regulation Of JAK-STAT Cascade Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M-mediated Signaling Pathway Response To Cytokine Positive Regulation Of Cell Proliferation Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Astrocyte Differentiation Cytokine-mediated Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Cellular Response To Cytokine Stimulus Negative Regulation Of Neuron Apoptotic Process Regulation Of Cell Proliferation Negative Regulation Of Neuron Death Positive Regulation Of Protein Phosphorylation Regulation Of Astrocyte Differentiation Regulation Of Neuron Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Glial Cell Differentiation Regulation Of Neuron Death Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Positive Regulation Of Gliogenesis Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Glial Cell Differentiation Positive Regulation Of Protein Metabolic Process Response To Organic Substance Positive Regulation Of Signal Transduction Regulation Of Cell Activation Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Interleukin-11-mediated Signaling Pathway Regulation Of Signal Transduction Regulation Of Gliogenesis Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Death Interleukin-27-mediated Signaling Pathway See more
Tagcloud ?		box chimeric coexpression consensus constructs contained converges dominant entire gp130 jak lacking mapk maximal maximally mitogen motif polypeptide polypeptides positions putative ras shp2 similarly stimulate stimulation tyk tyr y118f	acidic afgf albino bfgf ciliary college dystrophy fgf fgfr1 fibrillary gfap hybridizations igfr inherited injured minimize neurotrophic persisted photoreceptor prompt rcs retina royal slower subretinal surgeons trkb vicinity
Tagcloud (Difference) ?		box chimeric coexpression consensus constructs contained converges dominant entire gp130 jak lacking mapk maximal maximally mitogen motif polypeptide polypeptides positions putative ras shp2 similarly stimulate stimulation tyk tyr y118f	acidic afgf albino bfgf ciliary college dystrophy fgf fgfr1 fibrillary gfap hybridizations igfr inherited injured minimize neurotrophic persisted photoreceptor prompt rcs retina royal slower subretinal surgeons trkb vicinity
Tagcloud (Intersection) ?