LIFR and IL6ST

Number of citations of the paper that reports this interaction (PMID 8999038)
51

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		LIFR	IL6ST
Gene Name		leukemia inhibitory factor receptor alpha	interleukin 6 signal transducer
Image
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Receptor Complex Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Plasma Membrane Interleukin-6 Receptor Complex Oncostatin-M Receptor Complex External Side Of Plasma Membrane Membrane Dendrite Neuronal Cell Body Extracellular Vesicular Exosome Ciliary Neurotrophic Factor Receptor Complex
	Molecular Function	Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Growth Factor Binding	Ciliary Neurotrophic Factor Receptor Activity Interleukin-6 Receptor Activity Interleukin-11 Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Protein Binding Growth Factor Binding Interleukin-11 Binding Interleukin-6 Binding Protein Homodimerization Activity Interleukin-27 Receptor Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Response To Cytokine Oncostatin-M-mediated Signaling Pathway Leukemia Inhibitory Factor Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway	Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Adaptive Immune Response Glycogen Metabolic Process Positive Regulation Of Cell Proliferation Regulation Of Notch Signaling Pathway Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Cardiac Muscle Hypertrophy Viral Process Cytokine-mediated Signaling Pathway Response To Cytokine Interleukin-11-mediated Signaling Pathway Oncostatin-M-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Astrocyte Differentiation Leukemia Inhibitory Factor Signaling Pathway Interleukin-6-mediated Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Interleukin-27-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway
Pathways			Signaling by Interleukins Interleukin-6 signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS			Crohn's disease ( 23128233) IgG glycosylation ( 23382691) Rheumatoid arthritis ( 20453842)
Protein-Protein Interactions		12 interactors: CNTF CNTFR CTF1 IL31RA IL6ST LIF MAPK1 OSM PLCG1 POU2F1 PTPN11 PTPN6	31 interactors: AR CDK9 CNTF CNTFR CTF1 ERBB2 ERBB3 HCK IL31RA IL6 IL6R JAK1 KCNIP3 LIF LIFR MAGEA11 OSM OSMR PIK3CG PLAUR PRKCD PTPN11 PTPN6 SGTB SHC1 SOCS3 STAT3 TLE1 TYK2 UBQLN1 VAV1
Entrez ID		3977	3572
HPRD ID		01048	02824
Ensembl ID		ENSG00000113594	ENSG00000134352
Uniprot IDs		A8K1Z4 P42702	D6RH03 P40189 Q17RA0
PDB IDs		3E0G	1BJ8 1BQU 1I1R 1N2Q 1P9M 1PVH 3L5H 3L5I 3L5J
Enriched GO Terms of Interacting Partners?		Cellular Response To Cytokine Stimulus Response To Cytokine Cytokine-mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation JAK-STAT Cascade Regulation Of Protein Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Protein Phosphorylation Leukemia Inhibitory Factor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Signal Transduction Ciliary Neurotrophic Factor-mediated Signaling Pathway Regulation Of Phosphorylation System Development Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Multicellular Organismal Development Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Anatomical Structure Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of JAK-STAT Cascade Positive Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Developmental Process Regulation Of Cellular Protein Metabolic Process Signaling Cell Communication Regulation Of Protein Metabolic Process Regulation Of JAK-STAT Cascade Nervous System Development Cell Differentiation Abortive Mitotic Cell Cycle Regulation Of MAPK Cascade Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Signal Transduction Regulation Of Signal Transduction Regulation Of Immune System Process Organ Development Oncostatin-M-mediated Signaling Pathway	Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Cell Surface Receptor Signaling Pathway Response To Cytokine Cellular Response To Organic Substance Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Signaling Cellular Response To Stimulus Regulation Of Cell Proliferation Cell Communication Response To Organic Substance Positive Regulation Of Cell Proliferation Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Signal Transduction Response To Stimulus Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Defense Response Regulation Of Signaling Peptidyl-tyrosine Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Cell Death Response To Stress Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Ciliary Neurotrophic Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Phosphorus Metabolic Process Immune System Process Regulation Of Protein Metabolic Process JAK-STAT Cascade Positive Regulation Of Signal Transduction Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Immune Response Regulation Of Cellular Ketone Metabolic Process Leukocyte Migration Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Phosphorylation Negative Regulation Of Cell Death Positive Regulation Of Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction Regulation Of JAK-STAT Cascade
Tagcloud ?		box chimeric coexpression consensus constructs contained converges dominant entire gp130 jak lacking mapk maximal maximally mitogen motif polypeptide polypeptides positions putative ras shp2 similarly stimulate stimulation tyk tyr y118f	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il3ra lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Difference) ?		box chimeric coexpression consensus constructs contained converges dominant entire gp130 jak lacking mapk maximal maximally mitogen motif polypeptide polypeptides positions putative ras shp2 similarly stimulate stimulation tyk tyr y118f	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il3ra lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Intersection) ?		lifr