LIF and KRTAP12-3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LIF	KRTAP12-3
Description		LIF interleukin 6 family cytokine	keratin associated protein 12-3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Signaling Receptor Binding Cytokine Activity Leukemia Inhibitory Factor Receptor Binding Protein Binding Growth Factor Activity	Protein Binding Identical Protein Binding
	Biological Process	Cell Morphogenesis Response To Hypoxia Blood Vessel Remodeling Immune Response Embryo Implantation Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Gene Expression Positive Regulation Of Gene Expression Regulation Of Cell Communication Regulation Of Signaling Cell Differentiation Macrophage Differentiation Lung Development Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cell Adhesion Mediated By Integrin Somatic Stem Cell Population Maintenance Positive Regulation Of MAPK Cascade Regulation Of Cell Differentiation Positive Regulation Of Macrophage Differentiation Negative Regulation Of Meiotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Decidualization Negative Regulation Of Hormone Secretion Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Lung Alveolus Development Muscle Organ Morphogenesis Neuron Development Positive Regulation Of Astrocyte Differentiation Leukemia Inhibitory Factor Signaling Pathway Stem Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Multicellular Organismal Process Maternal Process Involved In Female Pregnancy Lung Vasculature Development Lung Lobe Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Cell Surface Receptor Signaling Pathway Via STAT Meiotic Nuclear Division Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Multicellular Organismal Development
Pathways		Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions	Keratinization
Drugs
Diseases
GWAS		Delirium ( 29631748) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 23128233) Inflammatory bowel disease (early onset) ( 19915574) Nephropathy ( 21399633) Tonsillectomy ( 27941131)
Interacting Genes		6 interacting genes: HPGDS IL6ST KRT31 KRTAP12-3 LIFR NCALD	145 interacting genes: ADAMTSL3 ADAMTSL4 AGXT ALDH3B1 BCL6B BMP7 C11orf87 C22orf39 CARD10 CATSPER1 CBX2 CELF5 CHIC2 CHRD CHRNG CNNM3 COL8A1 CRCT1 CREB5 CYSRT1 DALRD3 DHRS1 DHX57 DNAL4 DOCK2 FASLG FBXW5 GLRX3 GNE GTF3C5 HOXA1 ITGB4 JOSD1 KPRP KRT20 KRTAP1-1 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP13-1 KRTAP13-2 KRTAP13-3 KRTAP19-7 KRTAP3-3 KRTAP4-2 KRTAP4-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP9-2 KRTAP9-3 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LIF LMNTD2 LNX1 LYVE1 MAPKBP1 MEOX2 MISP MOBP NBPF19 NKD1 NMU NOTCH2NLA NPDC1 NR1D2 NR4A3 NUFIP2 OTX1 OXER1 P2RX4 P2RY6 P3H3 P4HB PDE9A PDGFRB PGAP6 PHLDA1 POU4F2 PTGDS PTPMT1 R3HDM2 RSPO2 SELENOM SHFL SLC13A5 SLC15A2 SLC23A1 SMCP SPATA3 SPRY1 TCEA2 TCEANC TFAP2D TMIE TNP2 TNS2 TTPA UTP23 UXT VASN VGLL3 VSTM4 WDR25 WNT11 YY1 ZDHHC1 ZNF101 ZNF124 ZNF138 ZNF20 ZNF408 ZNF417 ZNF439 ZNF440 ZNF467 ZNF490 ZNF491 ZNF497 ZNF578 ZNF587 ZNF648 ZNF696 ZNF80 ZNF835 ZNF837 ZSCAN21
Entrez ID		3976	386683
HPRD ID		08869	11199
Ensembl ID		ENSG00000128342	ENSG00000205439
Uniprot IDs		P15018	P60328
PDB IDs		1EMR 1PVH 2Q7N 7N0A 8D6A
Enriched GO Terms of Interacting Partners?		Leukemia Inhibitory Factor Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M Receptor Activity Oncostatin-M-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Ciliary Neurotrophic Factor Receptor Binding Cytokine Binding Growth Factor Binding Cytokine Receptor Activity Cell Body Interleukin-27 Receptor Activity Regulation Of Gliogenesis Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Keratin Filament Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Schwann Cell Proliferation Prostaglandin-D Synthase Activity Negative Regulation Of Male Germ Cell Proliferation Interleukin-11 Receptor Activity Interleukin-11 Binding Intermediate Filament Regulation Of Male Germ Cell Proliferation Regulation Of Cell Population Proliferation Negative Regulation Of Interleukin-6-mediated Signaling Pathway Regulation Of Germ Cell Proliferation Interleukin-11-mediated Signaling Pathway Receptor Complex Interleukin-6 Receptor Binding Clathrin Coat Of Trans-Golgi Network Vesicle Interleukin-27-mediated Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Positive Regulation Of Early Endosome To Late Endosome Transport Response To Nematode Intestinal Epithelial Cell Development Positive Regulation Of Protein Localization To Early Endosome Osteoblast Proliferation Response To Selenium Ion Positive Regulation Of Platelet Aggregation Positive Regulation Of Astrocyte Differentiation Positive Regulation Of Protein Localization To Endosome T-helper 17 Cell Lineage Commitment Negative Regulation Of Osteoblast Proliferation Ectoderm Development Columnar/cuboidal Epithelial Cell Development Lens Fiber Cell Differentiation Protein Tyrosine Kinase Activator Activity	Keratinization Intermediate Filament Epidermis Development Keratin Filament Protein Binding Tissue Development DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Regulation Of Transcription By RNA Polymerase II Identical Protein Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
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