LIF and HPGDS

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LIF	HPGDS
Description		LIF interleukin 6 family cytokine	hematopoietic prostaglandin D synthase
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Signaling Receptor Binding Cytokine Activity Leukemia Inhibitory Factor Receptor Binding Protein Binding Growth Factor Activity	Magnesium Ion Binding Glutathione Transferase Activity Prostaglandin-D Synthase Activity Calcium Ion Binding Protein Binding Transferase Activity Isomerase Activity Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Cell Morphogenesis Response To Hypoxia Blood Vessel Remodeling Immune Response Embryo Implantation Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Gene Expression Positive Regulation Of Gene Expression Regulation Of Cell Communication Regulation Of Signaling Cell Differentiation Macrophage Differentiation Lung Development Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cell Adhesion Mediated By Integrin Somatic Stem Cell Population Maintenance Positive Regulation Of MAPK Cascade Regulation Of Cell Differentiation Positive Regulation Of Macrophage Differentiation Negative Regulation Of Meiotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Decidualization Negative Regulation Of Hormone Secretion Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Lung Alveolus Development Muscle Organ Morphogenesis Neuron Development Positive Regulation Of Astrocyte Differentiation Leukemia Inhibitory Factor Signaling Pathway Stem Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Multicellular Organismal Process Maternal Process Involved In Female Pregnancy Lung Vasculature Development Lung Lobe Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Cell Surface Receptor Signaling Pathway Via STAT Meiotic Nuclear Division Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Multicellular Organismal Development	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Glutathione Metabolic Process Signal Transduction Locomotory Behavior Response To Nematode Response To Selenium Ion Negative Regulation Of Male Germ Cell Proliferation
Pathways		Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions	Glutathione conjugation Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs			Glutathione Tretinoin 2-(2f-Benzothiazolyl)-5-Styryl-3-(4f-Phthalhydrazidyl)Tetrazolium Chloride Glutathione disulfide Deoxycholic acid 3-phenyl-5-(1H-pyrazol-3-yl)isoxazole PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE Tranilast 4-{[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acid 4-(BENZHYDRYLOXY)-1-[3-(1H-TETRAAZOL-5-YL)PROPYL]PIPERIDINE Nocodazole 3-(4-nitrophenyl)-1H-pyrazole 1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
Diseases
GWAS		Delirium ( 29631748) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 23128233) Inflammatory bowel disease (early onset) ( 19915574) Nephropathy ( 21399633) Tonsillectomy ( 27941131)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Blood protein levels ( 30072576) Testicular germ cell tumor ( 23666239 28604728 28604732)
Interacting Genes		6 interacting genes: HPGDS IL6ST KRT31 KRTAP12-3 LIFR NCALD	7 interacting genes: ABHD17A ARRDC3 C14orf39 HK3 LIF MELTF PDE3B
Entrez ID		3976	27306
HPRD ID		08869	04001
Ensembl ID		ENSG00000128342	ENSG00000163106
Uniprot IDs		P15018	A0A384P5J0 O60760
PDB IDs		1EMR 1PVH 2Q7N 7N0A 8D6A	1IYH 1IYI 1V40 2CVD 2VCQ 2VCW 2VCX 2VCZ 2VD0 2VD1 3EE2 3KXO 3VI5 3VI7 4EC0 4EDY 4EDZ 4EE0 5AIS 5AIV 5AIX 5YWE 5YWX 5YX1 6N4E 6W58 6W8H 6ZTC 7JR6 7JR8
Enriched GO Terms of Interacting Partners?		Leukemia Inhibitory Factor Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M Receptor Activity Oncostatin-M-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Ciliary Neurotrophic Factor Receptor Binding Cytokine Binding Growth Factor Binding Cytokine Receptor Activity Cell Body Interleukin-27 Receptor Activity Regulation Of Gliogenesis Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Keratin Filament Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Schwann Cell Proliferation Prostaglandin-D Synthase Activity Negative Regulation Of Male Germ Cell Proliferation Interleukin-11 Receptor Activity Interleukin-11 Binding Intermediate Filament Regulation Of Male Germ Cell Proliferation Regulation Of Cell Population Proliferation Negative Regulation Of Interleukin-6-mediated Signaling Pathway Regulation Of Germ Cell Proliferation Interleukin-11-mediated Signaling Pathway Receptor Complex Interleukin-6 Receptor Binding Clathrin Coat Of Trans-Golgi Network Vesicle Interleukin-27-mediated Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Positive Regulation Of Early Endosome To Late Endosome Transport Response To Nematode Intestinal Epithelial Cell Development Positive Regulation Of Protein Localization To Early Endosome Osteoblast Proliferation Response To Selenium Ion Positive Regulation Of Platelet Aggregation Positive Regulation Of Astrocyte Differentiation Positive Regulation Of Protein Localization To Endosome T-helper 17 Cell Lineage Commitment Negative Regulation Of Osteoblast Proliferation Ectoderm Development Columnar/cuboidal Epithelial Cell Development Lens Fiber Cell Differentiation Protein Tyrosine Kinase Activator Activity	Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Heat Generation Hexokinase Activity Mannokinase Activity Glucokinase Activity Fructokinase Activity Leukemia Inhibitory Factor Signaling Pathway Leukemia Inhibitory Factor Receptor Binding Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Locomotion Involved In Locomotory Behavior Beta-3 Adrenergic Receptor Binding Negative Regulation Of Protein Localization To Microtubule Meiotic DNA Double-strand Break Processing Involved In Reciprocal Meiotic Recombination Meiotic DNA Double-strand Break Processing Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Postsynaptic Recycling Endosome Membrane Protein Depalmitoylation Positive Regulation Of Protein Metabolic Process Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Regulation Of Cell Adhesion Muscle Organ Morphogenesis Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Lung Lobe Morphogenesis Positive Regulation Of Plasminogen Activation Guanyl-nucleotide Exchange Factor Complex Regulation Of Locomotion Involved In Locomotory Behavior Heat Generation Central Element
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