LIF and IL6ST

Number of citations of the paper that reports this interaction (PMID 12707269)
9

Data Source:
HPRD (in vivo)

		LIF	IL6ST
Gene Name		leukemia inhibitory factor	interleukin 6 signal transducer
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm	Extracellular Region Extracellular Space Plasma Membrane Interleukin-6 Receptor Complex Oncostatin-M Receptor Complex External Side Of Plasma Membrane Membrane Dendrite Neuronal Cell Body Extracellular Vesicular Exosome Ciliary Neurotrophic Factor Receptor Complex
	Molecular Function	RNA Polymerase II Transcription Factor Recruiting Transcription Factor Activity Receptor Binding Cytokine Activity Leukemia Inhibitory Factor Receptor Binding Growth Factor Activity	Ciliary Neurotrophic Factor Receptor Activity Interleukin-6 Receptor Activity Interleukin-11 Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Protein Binding Growth Factor Binding Interleukin-11 Binding Interleukin-6 Binding Protein Homodimerization Activity Interleukin-27 Receptor Activity
	Biological Process	Blood Vessel Remodeling Transcription From RNA Polymerase II Promoter Immune Response Multicellular Organismal Development Embryo Implantation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Stem Cell Maintenance Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of MAPK Cascade Positive Regulation Of Macrophage Differentiation Negative Regulation Of Meiotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Decidualization Negative Regulation Of Hormone Secretion Lung Alveolus Development Muscle Organ Morphogenesis Neuron Development Positive Regulation Of Astrocyte Differentiation Leukemia Inhibitory Factor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Lung Vasculature Development Lung Lobe Morphogenesis Trophoblast Giant Cell Differentiation Spongiotrophoblast Differentiation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Histone H3-K27 Acetylation	Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Adaptive Immune Response Glycogen Metabolic Process Positive Regulation Of Cell Proliferation Regulation Of Notch Signaling Pathway Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Cardiac Muscle Hypertrophy Viral Process Cytokine-mediated Signaling Pathway Response To Cytokine Interleukin-11-mediated Signaling Pathway Oncostatin-M-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Astrocyte Differentiation Leukemia Inhibitory Factor Signaling Pathway Interleukin-6-mediated Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Interleukin-27-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway
Pathways			Signaling by Interleukins Interleukin-6 signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Inflammatory bowel disease (early onset) ( 19915574) Nephropathy ( 21399633)	Crohn's disease ( 23128233) IgG glycosylation ( 23382691) Rheumatoid arthritis ( 20453842)
Protein-Protein Interactions		2 interactors: IL6ST LIFR	31 interactors: AR CDK9 CNTF CNTFR CTF1 ERBB2 ERBB3 HCK IL31RA IL6 IL6R JAK1 KCNIP3 LIF LIFR MAGEA11 OSM OSMR PIK3CG PLAUR PRKCD PTPN11 PTPN6 SGTB SHC1 SOCS3 STAT3 TLE1 TYK2 UBQLN1 VAV1
Entrez ID		3976	3572
HPRD ID		08869	02824
Ensembl ID		ENSG00000128342	ENSG00000134352
Uniprot IDs		P15018	D6RH03 P40189 Q17RA0
PDB IDs		1EMR 1PVH 2Q7N	1BJ8 1BQU 1I1R 1N2Q 1P9M 1PVH 3L5H 3L5I 3L5J
Enriched GO Terms of Interacting Partners?		Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Interleukin-11-mediated Signaling Pathway Interleukin-27-mediated Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Astrocyte Differentiation Response To Cytokine Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Interleukin-6-mediated Signaling Pathway Positive Regulation Of Cell Proliferation Positive Regulation Of Cardiac Muscle Hypertrophy Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Interleukin-6 Positive Regulation Of Acute Inflammatory Response Regulation Of Astrocyte Differentiation Regulation Of Cardiac Muscle Hypertrophy Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Response To Interleukin-6 Positive Regulation Vascular Endothelial Growth Factor Production Negative Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Glial Cell Differentiation Negative Regulation Of Response To Cytokine Stimulus Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Cell Proliferation Positive Regulation Of Gliogenesis Glycogen Metabolic Process Positive Regulation Of JAK-STAT Cascade Regulation Of Notch Signaling Pathway Regulation Of Acute Inflammatory Response Positive Regulation Of Osteoblast Differentiation Cellular Response To Organic Substance Regulation Of Glial Cell Differentiation Polysaccharide Metabolic Process Positive Regulation Of T Cell Proliferation Regulation Of JAK-STAT Cascade Positive Regulation Of Inflammatory Response Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Ossification Regulation Of Gliogenesis Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Osteoblast Differentiation Response To Organic Substance Energy Reserve Metabolic Process	Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Cell Surface Receptor Signaling Pathway Response To Cytokine Cellular Response To Organic Substance Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Signaling Cellular Response To Stimulus Regulation Of Cell Proliferation Cell Communication Response To Organic Substance Positive Regulation Of Cell Proliferation Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Signal Transduction Response To Stimulus Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Defense Response Regulation Of Signaling Peptidyl-tyrosine Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Cell Death Response To Stress Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Ciliary Neurotrophic Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Phosphorus Metabolic Process Immune System Process Regulation Of Protein Metabolic Process JAK-STAT Cascade Positive Regulation Of Signal Transduction Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Immune Response Regulation Of Cellular Ketone Metabolic Process Leukocyte Migration Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Phosphorylation Negative Regulation Of Cell Death Positive Regulation Of Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction Regulation Of JAK-STAT Cascade
Tagcloud ?		cis1 cis3 ctll2 cytokine fcgammari forced fos hel ifnbeta ifngamma il6 ilf jab jak jh1 kinetics m1 modulators ones parental possess possesses sh2 slower structurally supporting unlike ut weaker	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il3ra lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Difference) ?		cis1 cis3 ctll2 cytokine fcgammari forced fos hel ifnbeta ifngamma il6 ilf jab jak jh1 kinetics m1 modulators ones parental possess possesses sh2 slower structurally supporting unlike ut weaker	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il3ra lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Intersection) ?