LIF and LIFR

Number of citations: 0 (PubMedID 12601009)
Data Source: BioGRID (pull down), HPRD (in vitro)

		LIF	LIFR
Name		LIF interleukin 6 family cytokine	LIF receptor subunit alpha
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Cytokine Activity Leukemia Inhibitory Factor Receptor Binding Protein Binding Growth Factor Activity	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Growth Factor Binding Cytokine Binding
	Biological Process	Cell Morphogenesis Response To Hypoxia Blood Vessel Remodeling Immune Response Embryo Implantation Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Gene Expression Positive Regulation Of Gene Expression Regulation Of Cell Communication Regulation Of Signaling Cell Differentiation Macrophage Differentiation Lung Development Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cell Adhesion Mediated By Integrin Somatic Stem Cell Population Maintenance Positive Regulation Of MAPK Cascade Regulation Of Cell Differentiation Positive Regulation Of Macrophage Differentiation Negative Regulation Of Meiotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Decidualization Negative Regulation Of Hormone Secretion Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Lung Alveolus Development Muscle Organ Morphogenesis Neuron Development Positive Regulation Of Astrocyte Differentiation Leukemia Inhibitory Factor Signaling Pathway Stem Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Multicellular Organismal Process Maternal Process Involved In Female Pregnancy Lung Vasculature Development Lung Lobe Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Cell Surface Receptor Signaling Pathway Via STAT Meiotic Nuclear Division Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Multicellular Organismal Development	Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Response To Cytokine Oncostatin-M-mediated Signaling Pathway Leukemia Inhibitory Factor Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway
Pathways		Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions	IL-6-type cytokine receptor ligand interactions RUNX1 regulates transcription of genes involved in interleukin signaling
Diseases		None	Stuve-Wiedemann syndrome
GWAS		Delirium ( 29631748 ) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644 ) Heel bone mineral density ( 30598549 ) Inflammatory bowel disease ( 23128233 ) Inflammatory bowel disease (early onset) ( 19915574 ) Nephropathy ( 21399633 ) Tonsillectomy ( 27941131 )	Blood protein levels ( 30072576 ) Crohn's disease ( 26192919 ) Inflammatory bowel disease ( 26192919 ) Pursuit maintenance gain ( 29064472 ) Ulcerative colitis ( 26192919 )
Interacting Genes		6 interacting genes: HPGDS IL6ST KRT31 KRTAP12-3 LIFR NCALD	12 interacting genes: CNTF CNTFR CTF1 IL31RA IL6ST LIF MAPK1 OSM PLCG1 POU2F1 PTPN11 PTPN6
Entrez ID		3976	3977
HPRD ID		08869	01048
Ensembl ID		ENSG00000128342	ENSG00000113594
Uniprot IDs		P15018	A8K1Z4 P42702
PDB IDs		1EMR 1PVH 2Q7N 7N0A 8D6A	3E0G 8D6A 8D74 8D7R 8V29 8V2A
GO Terms Enriched among Interactors		Leukemia Inhibitory Factor Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M Receptor Activity Oncostatin-M-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Ciliary Neurotrophic Factor Receptor Binding Cytokine Binding Growth Factor Binding Cytokine Receptor Activity Cell Body Interleukin-27 Receptor Activity Regulation Of Gliogenesis Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Keratin Filament Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Schwann Cell Proliferation Prostaglandin-D Synthase Activity Negative Regulation Of Male Germ Cell Proliferation Interleukin-11 Receptor Activity Interleukin-11 Binding Intermediate Filament Regulation Of Male Germ Cell Proliferation Regulation Of Cell Population Proliferation Negative Regulation Of Interleukin-6-mediated Signaling Pathway Regulation Of Germ Cell Proliferation Interleukin-11-mediated Signaling Pathway Receptor Complex Interleukin-6 Receptor Binding Clathrin Coat Of Trans-Golgi Network Vesicle Interleukin-27-mediated Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Positive Regulation Of Early Endosome To Late Endosome Transport Response To Nematode Intestinal Epithelial Cell Development Positive Regulation Of Protein Localization To Early Endosome Osteoblast Proliferation Response To Selenium Ion Positive Regulation Of Platelet Aggregation Positive Regulation Of Astrocyte Differentiation Positive Regulation Of Protein Localization To Endosome T-helper 17 Cell Lineage Commitment Negative Regulation Of Osteoblast Proliferation Ectoderm Development Columnar/cuboidal Epithelial Cell Development Lens Fiber Cell Differentiation Protein Tyrosine Kinase Activator Activity	Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Tyrosine Phosphorylation Of STAT Protein Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Phosphorylation Leukemia Inhibitory Factor Receptor Binding Cell Development Regulation Of Phosphorus Metabolic Process Ciliary Neurotrophic Factor Receptor Complex Positive Regulation Of Macromolecule Metabolic Process Signal Transduction Regulation Of Protein Modification Process Interleukin-11 Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Binding Enzyme-linked Receptor Protein Signaling Pathway Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M-mediated Signaling Pathway Cytokine Binding Phosphotyrosine Residue Binding Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Metabolic Process Cytokine Receptor Activity Regulation Of Inflammatory Response Response To Epidermal Growth Factor Ciliary Neurotrophic Factor Receptor Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Protein Metabolic Process Interleukin-6 Receptor Binding Interleukin-11-mediated Signaling Pathway Regulation Of Defense Response Negative Regulation Of Neutrophil Activation Epidermal Growth Factor Receptor Signaling Pathway Cytokine Activity Muscle Organ Morphogenesis Negative Regulation Of Hormone Secretion Regulation Of Multicellular Organismal Process ERBB Signaling Pathway