LIF

Name	LIF interleukin 6 family cytokine
Structure
Novel Interactors	1 novel interactors: NF2
Interactors	6 interactors: HPGDS IL6ST KRT31 KRTAP12-3 LIFR NCALD
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol
	Molecular Function	Signaling Receptor Binding Cytokine Activity Leukemia Inhibitory Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Cell Morphogenesis Response To Hypoxia Blood Vessel Remodeling Immune Response Embryo Implantation Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Gene Expression Positive Regulation Of Gene Expression Regulation Of Cell Communication Regulation Of Signaling Cell Differentiation Macrophage Differentiation Lung Development Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cell Adhesion Mediated By Integrin Somatic Stem Cell Population Maintenance Positive Regulation Of MAPK Cascade Regulation Of Cell Differentiation Positive Regulation Of Macrophage Differentiation Negative Regulation Of Meiotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Decidualization Negative Regulation Of Hormone Secretion Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Lung Alveolus Development Muscle Organ Morphogenesis Neuron Development Positive Regulation Of Astrocyte Differentiation Leukemia Inhibitory Factor Signaling Pathway Stem Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Multicellular Organismal Process Maternal Process Involved In Female Pregnancy Lung Vasculature Development Lung Lobe Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Cell Surface Receptor Signaling Pathway Via STAT Meiotic Nuclear Division Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Multicellular Organismal Development
Pathways	Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions
GWAS	Delirium ( 29631748 ) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644 ) Heel bone mineral density ( 30598549 ) Inflammatory bowel disease ( 23128233 ) Inflammatory bowel disease (early onset) ( 19915574 ) Nephropathy ( 21399633 ) Tonsillectomy ( 27941131 )
Entrez ID	3976
HPRD ID	08869
Ensembl ID	ENSG00000128342
Uniprot IDs	P15018
PDB IDs	1EMR 1PVH 2Q7N 7N0A 8D6A
GO Terms Enriched among Interactors ?	Leukemia Inhibitory Factor Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M Receptor Activity Oncostatin-M-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Ciliary Neurotrophic Factor Receptor Binding Cytokine Binding Growth Factor Binding Cytokine Receptor Activity Cell Body Interleukin-27 Receptor Activity Regulation Of Gliogenesis Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Keratin Filament Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Schwann Cell Proliferation Prostaglandin-D Synthase Activity Negative Regulation Of Male Germ Cell Proliferation Interleukin-11 Receptor Activity Interleukin-11 Binding Intermediate Filament Regulation Of Male Germ Cell Proliferation Regulation Of Cell Population Proliferation Negative Regulation Of Interleukin-6-mediated Signaling Pathway Regulation Of Germ Cell Proliferation Interleukin-11-mediated Signaling Pathway Receptor Complex Interleukin-6 Receptor Binding Clathrin Coat Of Trans-Golgi Network Vesicle Interleukin-27-mediated Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Positive Regulation Of Early Endosome To Late Endosome Transport Response To Nematode Intestinal Epithelial Cell Development Positive Regulation Of Protein Localization To Early Endosome Osteoblast Proliferation Response To Selenium Ion Positive Regulation Of Platelet Aggregation Positive Regulation Of Astrocyte Differentiation Positive Regulation Of Protein Localization To Endosome T-helper 17 Cell Lineage Commitment Negative Regulation Of Osteoblast Proliferation Ectoderm Development Columnar/cuboidal Epithelial Cell Development Lens Fiber Cell Differentiation Protein Tyrosine Kinase Activator Activity