LGALS3 and MYOC

Number of citations of the paper that reports this interaction (PMID 16289162)
20

Data Source:
HPRD (two hybrid)

		LGALS3	MYOC
Gene Name		lectin, galactoside-binding, soluble, 3	myocilin, trabecular meshwork inducible glucocorticoid response
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Immunological Synapse Proteinaceous Extracellular Matrix Extracellular Space Nucleus Spliceosomal Complex Cytoplasm Mitochondrial Inner Membrane Plasma Membrane External Side Of Plasma Membrane Membrane Extracellular Matrix Extracellular Vesicular Exosome	Proteinaceous Extracellular Matrix Extracellular Space Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Cytoplasmic Membrane-bounded Vesicle Extracellular Matrix Cytoplasmic Vesicle Node Of Ranvier Extracellular Vesicular Exosome
	Molecular Function	Protein Binding IgE Binding Carbohydrate Binding Chemoattractant Activity Laminin Binding Poly(A) RNA Binding	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding
	Biological Process	Skeletal System Development Monocyte Chemotaxis MRNA Processing RNA Splicing Extracellular Matrix Organization Neutrophil Chemotaxis Epithelial Cell Differentiation Regulation Of T Cell Proliferation Innate Immune Response Negative Regulation Of Endocytosis Eosinophil Chemotaxis Macrophage Chemotaxis Negative Regulation Of T Cell Receptor Signaling Pathway Positive Chemotaxis Regulation Of T Cell Apoptotic Process Mononuclear Cell Migration Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Calcium Ion Import Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Immunological Synapse Formation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway Via JNK Cascade ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Advanced glycosylation endproduct receptor signaling Innate Immune System
Drugs
Diseases
GWAS		Protein biomarker ( 23056639)
Protein-Protein Interactions		20 interactors: APP BARD1 C1GALT1C1 CSNK1A1 CSNK2A1 CSNK2A2 CUBN CYHR1 ELN FCGR2A GEMIN4 GOLGA2 LGALS3BP LIM2 MMP2 MYOC PPIG PRR13 SS18L1 SUFU	40 interactors: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 TGFBR1 TIMP1 TKT TNFRSF1A
Entrez ID		3958	4653
HPRD ID		01090	03387
Ensembl ID		ENSG00000131981	ENSG00000034971
Uniprot IDs		P17931	Q99972
PDB IDs		1A3K 1KJL 1KJR 2NMN 2NMO 2NN8 2XG3 3AYA 3AYC 3AYD 3AYE 3T1L 3T1M 3ZSJ 3ZSK 3ZSL 3ZSM 4JC1 4JCK
Enriched GO Terms of Interacting Partners?		Neuron Differentiation Neuron Projection Development Negative Regulation Of Cellular Protein Catabolic Process Wnt Signaling Pathway Neuron Development Negative Regulation Of Protein Catabolic Process Endocytosis Generation Of Neurons Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Neurogenesis Cell Projection Organization Cell Morphogenesis Involved In Differentiation Regulation Of Protein Catabolic Process Axon Guidance Regulation Of Protein Processing Neuron Maturation Cell Development Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Axonogenesis Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Metaphase/anaphase Transition Skeletal Muscle Hypertrophy ERBB2-ERBB3 Signaling Pathway Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cell Morphogenesis Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nervous System Development Negative Regulation Of Proteasomal Protein Catabolic Process Neuron Projection Morphogenesis Cell Surface Receptor Signaling Pathway Regulation Of Proteolysis Synaptic Growth At Neuromuscular Junction ERBB2 Signaling Pathway Negative Regulation Of MRNA 3'-end Processing Anatomical Structure Morphogenesis Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Negative Regulation Of Intracellular Protein Transport Negative Regulation Of Chromosome Organization Collateral Sprouting In Absence Of Injury Mitotic Cell Cycle Extracellular Matrix Disassembly	Extracellular Matrix Organization Extracellular Structure Organization Platelet Activation Extracellular Matrix Disassembly Cell Activation Response To Wounding Blood Coagulation Regulation Of Body Fluid Levels Hemostasis Wound Healing Cardiovascular System Development Collagen Fibril Organization System Development Developmental Process Blood Vessel Development Platelet Degranulation Multicellular Organismal Development Vasculature Development Glycolytic Process Organ Development Pyruvate Metabolic Process Pathogenesis Anatomical Structure Development Response To Stress Anatomical Structure Morphogenesis Monosaccharide Metabolic Process Carbohydrate Catabolic Process Locomotion Cell Development Glucose Metabolic Process Cell Differentiation Regulation Of Cellular Component Movement Vesicle-mediated Transport Response To Stimulus Movement Of Cell Or Subcellular Component Hexose Metabolic Process Immune System Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Skeletal System Development Platelet Aggregation Generation Of Precursor Metabolites And Energy Blood Vessel Morphogenesis Secretion Regulation Of Cell Motility Regulation Of Immune Response Organic Acid Metabolic Process Tissue Development Regulation Of Locomotion Cell Adhesion
Tagcloud ?		clnd23 clnd8 colorectal cytoscape database david degs detailed differentially downloaded downregulated enriched foxo3 go gse8671 microarray network omnibus ontology pgfdr ppi shed spia string tcf7l2 tfats top upregulated valuable	accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glaucoma glycerol hubs hydrophilic inherited mapped movements myocilin ocular olf olfactomedin onto overlapping propellers pursuit solved synonymous
Tagcloud (Difference) ?		clnd23 clnd8 colorectal cytoscape database david degs detailed differentially downloaded downregulated enriched foxo3 go gse8671 microarray network omnibus ontology pgfdr ppi shed spia string tcf7l2 tfats top upregulated valuable	accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glaucoma glycerol hubs hydrophilic inherited mapped movements myocilin ocular olf olfactomedin onto overlapping propellers pursuit solved synonymous
Tagcloud (Intersection) ?