LGALS3 and FCGR2A

Number of citations of the paper that reports this interaction (PubMedID 10704522)
0

Data Source:
HPRD (in vitro)

		LGALS3	FCGR2A
Description		galectin 3	Fc gamma receptor IIa
Image
GO Annotations	Cellular Component	Immunological Synapse Extracellular Region Extracellular Space Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Mitochondrial Inner Membrane Cytosol Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Extracellular Matrix Extracellular Exosome Ficolin-1-rich Granule Membrane	Plasma Membrane External Side Of Plasma Membrane Membrane Secretory Granule Membrane
	Molecular Function	RNA Binding Protein Phosphatase Inhibitor Activity Protein Binding IgE Binding Protein Phosphatase Binding Carbohydrate Binding Signaling Receptor Inhibitor Activity Chemoattractant Activity Laminin Binding Disaccharide Binding Oligosaccharide Binding Molecular Condensate Scaffold Activity Receptor Ligand Inhibitor Activity	Protein Binding IgG Receptor Activity IgG Binding
	Biological Process	Immune System Process Monocyte Chemotaxis MRNA Processing RNA Splicing Cell Differentiation Neutrophil Chemotaxis Epithelial Cell Differentiation Positive Regulation Of Protein-containing Complex Assembly Killing Of Cells Of Another Organism Regulation Of T Cell Proliferation Innate Immune Response Negative Regulation Of Endocytosis Eosinophil Chemotaxis Macrophage Chemotaxis Negative Regulation Of T Cell Receptor Signaling Pathway Positive Chemotaxis NK T Cell Activation Negative Regulation Of NK T Cell Activation Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Regulation Of T Cell Apoptotic Process Mononuclear Cell Migration Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Calcium Ion Import Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Immunological Synapse Formation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Dendritic Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Antibody-dependent Cellular Cytotoxicity Immune System Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Fc-gamma Receptor Signaling Pathway Positive Regulation Of Phagocytosis
Pathways		Neutrophil degranulation Advanced glycosylation endproduct receptor signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX2 regulates genes involved in differentiation of myeloid cells	FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Neutrophil degranulation FCGR3A-mediated IL10 synthesis
Drugs		2,3,5,6-Tetrafluoro-4-Methoxy-Benzamide Lactose	Cetuximab Etanercept Human immunoglobulin G Abciximab Alemtuzumab Daclizumab Bevacizumab Catumaxomab Sarilumab
Diseases			Systemic lupus erythematosus
GWAS		Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Leukoderma in response to rhododendrol ( 32558222) Protein biomarker ( 23056639) Testicular germ cell tumor ( 28604728)	Ankylosing spondylitis ( 23749187) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Hematocrit ( 27863252) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 28067908 23128233) Kawasaki disease ( 33772158 28886140 22081228) Lipid metabolism phenotypes ( 22286219) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 26663301 28714469 27399966 26502338 24871463) Takayasu arteritis ( 23830517) Ulcerative colitis ( 28067908 19915573 21297633 20228799)
Interacting Genes		32 interacting genes: ANXA1 APP C1GALT1C1 CRX CSNK1A1 CSNK2A1 CSNK2A2 CUBN ELN FCGR2A GEMIN4 GOLGA2 INCA1 KIF16B LGALS3BP LIM2 LINC00632 MCAM MCPH1 MEFV MMP2 MYOC PPIG PRR13 SNCA SS18L1 SUFU TRIM17 TRIM22 TRIM23 TRIM6 ZFTRAF1	26 interacting genes: ADAM33 AGPAT4 BLK CDIPT CMTM5 CRP CRYAB CSGALNACT2 CXCL9 FXYD3 FYN GIMAP1 GP6 GRB2 HCK LAT LGALS3 LYN MIP NSG1 PIK3R1 SERP2 SHC1 SYK UBQLN1 UPK2
Entrez ID		3958	2212
HPRD ID		01090	00906
Ensembl ID		ENSG00000131981	ENSG00000143226
Uniprot IDs		A0A024R693 P17931	A0A8V8TPS4 P12318
PDB IDs		1A3K 1KJL 1KJR 2NMN 2NMO 2NN8 2XG3 3AYA 3AYC 3AYD 3AYE 3T1L 3T1M 3ZSJ 3ZSK 3ZSL 3ZSM 4BLI 4BLJ 4BM8 4JC1 4JCK 4LBJ 4LBK 4LBL 4LBM 4LBN 4LBO 4R9A 4R9B 4R9C 4R9D 4RL7 4XBN 5E88 5E89 5E8A 5EXO 5H9P 5H9R 5IUQ 5NF7 5NF9 5NFA 5NFB 5NFC 5OAX 5ODY 6B8K 6EOG 6EOL 6EXY 6EYM 6F2Q 6F6Y 6FK2 6FOF 6G0V 6H64 6I74 6I75 6I76 6I77 6I78 6KXA 6KXB 6Q0Q 6Q17 6QGE 6QGF 6QLN 6QLO 6QLP 6QLQ 6QLR 6QLS 6QLT 6QLU 6RHL 6RHM 6RZF 6RZG 6RZH 6RZI 6RZJ 6RZK 6RZL 6RZM 6TF6 6TF7 6Y4C 6Y78 6ZVF 7BE3 7CXA 7DF5 7RDO 7RDP 7RGX 7RGY 7RGZ 7RH0 7RH1 7RH3 7RH4 7XFA 7ZQX 8BZ3 8ITX 8ITZ 8OJI 8OJK 8OJM 8OJO 8PBF 8PF9 8PFF 8PPN 8RMT 8RMU 8RMV 8RR7 8RR8 8RR9 8RRA 8RRB 8RRC 8RRE 8RRF 8RRG 8S67 8YMD 8Z1S 8Z1T 8Z25 8ZUV	1FCG 1H9V 3D5O 3RY4 3RY5 3RY6 8CHA
Enriched GO Terms of Interacting Partners?		Regulation Of Autophagy Positive Regulation Of Autophagy Protein Kinase CK2 Complex Positive Regulation Of Catabolic Process Negative Regulation Of Catabolic Process Innate Immune Response Defense Response To Symbiont Defense Response To Other Organism Defense Response Response To External Biotic Stimulus Cell Surface Receptor Signaling Pathway Positive Regulation Of Vesicle Fusion Response To Interleukin-1 Regulation Of Proteolysis Protein Tetramerization Regulation Of Protein Catabolic Process Regulation Of Neurotransmitter Uptake Ubiquitin Protein Ligase Activity Negative Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Defense Response Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Metabolic Process Regulation Of Inflammatory Response Response To Other Organism Vesicle-mediated Transport Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Cellular Response To Copper Ion Identical Protein Binding Negative Regulation Of Autophagy Regulation Of Receptor Recycling	Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Effector Process Immune Response-regulating Signaling Pathway Leukocyte Degranulation Regulation Of Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Regulated Exocytosis Negative Regulation Of Inflammatory Response To Antigenic Stimulus Leukocyte Migration Non-membrane Spanning Protein Tyrosine Kinase Activity Lymphocyte Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Peptidyl-tyrosine Phosphorylation Immune Response Cell Activation IgE Binding Negative Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Adaptive Immune Response Lymphocyte Mediated Immunity Fc-epsilon Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Leukocyte Activation Mast Cell Degranulation Exocytosis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune System Process Membrane Defense Response Negative Regulation Of Immune Response Ephrin Receptor Binding Regulation Of Reactive Oxygen Species Metabolic Process Leukocyte Mediated Immunity Immune Response-activating Signaling Pathway Regulation Of Cell Activation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Response To Stress Hypersensitivity Immunoglobulin Mediated Immune Response Secretion By Cell Response To Other Organism Regulation Of Transport Activation Of Immune Response IgG Binding Defense Response To Symbiont B Cell Mediated Immunity
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