LGALS3 and GEMIN4

Number of citations of the paper that reports this interaction (PMID 11522829)
20

Data Source:
HPRD (in vitro, in vivo)

		LGALS3	GEMIN4
Gene Name		lectin, galactoside-binding, soluble, 3	gem (nuclear organelle) associated protein 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Immunological Synapse Proteinaceous Extracellular Matrix Extracellular Space Nucleus Spliceosomal Complex Cytoplasm Mitochondrial Inner Membrane Plasma Membrane External Side Of Plasma Membrane Membrane Extracellular Matrix Extracellular Vesicular Exosome	Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Small Nuclear Ribonucleoprotein Complex SMN Complex SMN-Sm Protein Complex Extracellular Vesicular Exosome Gemini Of Coiled Bodies
	Molecular Function	Protein Binding IgE Binding Carbohydrate Binding Chemoattractant Activity Laminin Binding Poly(A) RNA Binding	Protein Binding
	Biological Process	Skeletal System Development Monocyte Chemotaxis MRNA Processing RNA Splicing Extracellular Matrix Organization Neutrophil Chemotaxis Epithelial Cell Differentiation Regulation Of T Cell Proliferation Innate Immune Response Negative Regulation Of Endocytosis Eosinophil Chemotaxis Macrophage Chemotaxis Negative Regulation Of T Cell Receptor Signaling Pathway Positive Chemotaxis Regulation Of T Cell Apoptotic Process Mononuclear Cell Migration Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Calcium Ion Import Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Immunological Synapse Formation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Spliceosomal SnRNP Assembly RRNA Processing Gene Expression NcRNA Metabolic Process
Pathways		Advanced glycosylation endproduct receptor signaling Innate Immune System	snRNP Assembly Metabolism of non-coding RNA
Drugs
Diseases
GWAS		Protein biomarker ( 23056639)	Prostate cancer ( 23535732)
Protein-Protein Interactions		20 interactors: APP BARD1 C1GALT1C1 CSNK1A1 CSNK2A1 CSNK2A2 CUBN CYHR1 ELN FCGR2A GEMIN4 GOLGA2 LGALS3BP LIM2 MMP2 MYOC PPIG PRR13 SS18L1 SUFU	25 interactors: AGO2 CALCOCO2 DDX20 DHX9 DMPK FLAD1 GEMIN5 GLYR1 KARS LGALS1 LGALS3 MORC4 PIAS3 RN7SL1 RNU1-1 RNU2-1 SNRPB SNRPD1 SNRPD2 SPRY1 SQSTM1 SRRT STXBP2 STXBP3 TOP1
Entrez ID		3958	50628
HPRD ID		01090	07370
Ensembl ID		ENSG00000131981	ENSG00000179409
Uniprot IDs		P17931	I3L2C7 P57678 Q8WUM5
PDB IDs		1A3K 1KJL 1KJR 2NMN 2NMO 2NN8 2XG3 3AYA 3AYC 3AYD 3AYE 3T1L 3T1M 3ZSJ 3ZSK 3ZSL 3ZSM 4JC1 4JCK
Enriched GO Terms of Interacting Partners?		Neuron Differentiation Neuron Projection Development Negative Regulation Of Cellular Protein Catabolic Process Wnt Signaling Pathway Neuron Development Negative Regulation Of Protein Catabolic Process Endocytosis Generation Of Neurons Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Neurogenesis Cell Projection Organization Cell Morphogenesis Involved In Differentiation Regulation Of Protein Catabolic Process Axon Guidance Regulation Of Protein Processing Neuron Maturation Cell Development Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Axonogenesis Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Metaphase/anaphase Transition Skeletal Muscle Hypertrophy ERBB2-ERBB3 Signaling Pathway Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cell Morphogenesis Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nervous System Development Negative Regulation Of Proteasomal Protein Catabolic Process Neuron Projection Morphogenesis Cell Surface Receptor Signaling Pathway Regulation Of Proteolysis Synaptic Growth At Neuromuscular Junction ERBB2 Signaling Pathway Negative Regulation Of MRNA 3'-end Processing Anatomical Structure Morphogenesis Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Negative Regulation Of Intracellular Protein Transport Negative Regulation Of Chromosome Organization Collateral Sprouting In Absence Of Injury Mitotic Cell Cycle Extracellular Matrix Disassembly	Spliceosomal SnRNP Assembly RNA Processing MRNA Processing NcRNA Metabolic Process Ribonucleoprotein Complex Assembly MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Ribonucleoprotein Complex Biogenesis Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecular Complex Assembly Neutrophil Degranulation RNA Metabolic Process Nitrogen Compound Metabolic Process Neutrophil Activation Involved In Immune Response Gene Expression Immune Response Cellular Component Assembly Neutrophil Mediated Immunity Production Of MiRNAs Involved In Gene Silencing By MiRNA Neutrophil Activation Immune System Process Leukocyte Activation Involved In Immune Response Gene Silencing By MiRNA Cellular Response To DsRNA Posttranscriptional Gene Silencing Leukocyte Degranulation Lysyl-tRNA Aminoacylation Negative Regulation Of Immunological Synapse Formation FAD Biosynthetic Process Positive Regulation Of Erythrocyte Aggregation Regulated Secretory Pathway Vesicle Docking Involved In Exocytosis Spliceosomal Complex Assembly Gene Silencing By RNA Cellular Metabolic Process MRNA Cleavage Involved In Gene Silencing By MiRNA Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Diadenosine Tetraphosphate Biosynthetic Process Response To DsRNA Cellular Process Vesicle Docking Membrane Docking SiRNA Loading Onto RISC Involved In RNA Interference Positive Regulation Of Mononuclear Cell Migration Mononuclear Cell Migration
Tagcloud ?		clnd23 clnd8 colorectal cytoscape database david degs detailed differentially downloaded downregulated enriched foxo3 go gse8671 microarray network omnibus ontology pgfdr ppi shed spia string tcf7l2 tfats top upregulated valuable	a1 a11 a2 a4 a5 a6 accomplishments annealing annexin annexins carbohydrate conjunction cytoplasm cytoskeleton extensively galectin galectins helicase inside interacting lectin lectins outside phospholipid possesses primer summarizes synexin unwinding
Tagcloud (Difference) ?		clnd23 clnd8 colorectal cytoscape database david degs detailed differentially downloaded downregulated enriched foxo3 go gse8671 microarray network omnibus ontology pgfdr ppi shed spia string tcf7l2 tfats top upregulated valuable	a1 a11 a2 a4 a5 a6 accomplishments annealing annexin annexins carbohydrate conjunction cytoplasm cytoskeleton extensively galectin galectins helicase inside interacting lectin lectins outside phospholipid possesses primer summarizes synexin unwinding
Tagcloud (Intersection) ?