GHRL and GHSR

Number of citations of the paper that reports this interaction (PMID 10604470)
664

Data Source:
HPRD (in vivo)

		GHRL	GHSR
Gene Name		ghrelin/obestatin prepropeptide	growth hormone secretagogue receptor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Axon Secretory Granule Lumen	Plasma Membrane Cell Surface Integral Component Of Membrane Neuron Projection Membrane Raft
	Molecular Function	G-protein Coupled Receptor Binding Growth Hormone-releasing Hormone Activity Protein Tyrosine Kinase Activator Activity Ghrelin Receptor Binding	Growth Hormone Secretagogue Receptor Activity G-protein Coupled Receptor Activity Growth Hormone-releasing Hormone Receptor Activity Peptide Hormone Binding
	Biological Process	Activation Of MAPK Activity Gastric Acid Secretion Negative Regulation Of Endothelial Cell Proliferation Glucose Metabolic Process G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Actin Polymerization Or Depolymerization Adult Feeding Behavior Response To Hormone Hormone-mediated Signaling Pathway Dendrite Development Negative Regulation Of Angiogenesis Growth Hormone Secretion Positive Regulation Of Insulin Secretion Regulation Of Response To Food Positive Regulation Of Appetite Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Locomotion Positive Regulation Of Multicellular Organism Growth Regulation Of Cell Proliferation Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Negative Regulation Of Apoptotic Process Cortisol Secretion Response To Estrogen Cellular Protein Metabolic Process Negative Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Insulin Secretion Decidualization Negative Regulation Of Inflammatory Response Cartilage Development Positive Regulation Of Corticotropin Secretion Positive Regulation Of Cortisol Secretion Positive Regulation Of Synapse Assembly Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity	G-protein Coupled Receptor Signaling Pathway Actin Polymerization Or Depolymerization Adult Feeding Behavior Response To Hormone Hormone-mediated Signaling Pathway Growth Hormone Secretion Response To Food Positive Regulation Of Appetite Negative Regulation Of Interleukin-1 Beta Production Cellular Response To Insulin Stimulus Positive Regulation Of Multicellular Organism Growth Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Regulation Of Hindgut Contraction Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Fatty Acid Metabolic Process Negative Regulation Of Insulin Secretion Decidualization Negative Regulation Of Inflammatory Response Regulation Of Synapse Assembly
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Height ( 20881960 23563607)
Protein-Protein Interactions		8 interactors: ACE2 AGRP GHRHR GHSR LEP MLNR NPY UBQLN1	2 interactors: CORT GHRL
Entrez ID		51738	2693
HPRD ID		05638	03541
Ensembl ID		ENSG00000157017	ENSG00000121853
Uniprot IDs		Q9UBU3	Q92847
PDB IDs		1P7X
Enriched GO Terms of Interacting Partners?		Adult Feeding Behavior Feeding Behavior Regulation Of Response To Food Regulation Of Appetite Adult Behavior Behavior Female Pregnancy Positive Regulation Of Appetite Regulation Of Hormone Levels Peptide Hormone Secretion Peptide Secretion Response To Insulin Maternal Process Involved In Female Pregnancy Multicellular Organismal Reproductive Process Hormone Secretion Multicellular Organism Reproduction Hormone Transport Peptide Transport Growth Hormone Secretion Digestion Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Reproduction Single-organism Behavior Response To Peptide Hormone Amide Transport Response To Peptide G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Developmental Growth Regulation Of Blood Pressure Cellular Response To Hormone Stimulus Hormone Metabolic Process Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Reproductive Process Regulation Of Peptide Hormone Secretion Eating Behavior Positive Regulation Of Growth Regulation Of Hormone Secretion Negative Regulation Of Peptide Secretion Response To Organonitrogen Compound Regulation Of Developmental Growth Cell Surface Receptor Signaling Pathway Blood Circulation Cell-cell Signaling Positive Regulation Of Multicellular Organism Growth Response To Hormone Regulation Of Vasoconstriction Negative Regulation Of Hormone Secretion Response To Stimulus Regulation Of Protein Metabolic Process Response To Nutrient Levels	Cortisol Secretion Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Cortisol Secretion Positive Regulation Of Corticotropin Secretion Positive Regulation Of Appetite Regulation Of Corticotropin Secretion Regulation Of Growth Hormone Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle, REM Sleep Negative Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Growth Hormone Secretion Synaptic Transmission Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Adult Feeding Behavior Gastric Acid Secretion Regulation Of Growth Hormone Secretion Growth Hormone Secretion Negative Regulation Of Interleukin-1 Beta Production Regulation Of Circadian Sleep/wake Cycle, Sleep Cell-cell Signaling Regulation Of Response To Food Positive Regulation Of Circadian Rhythm Regulation Of Tumor Necrosis Factor Biosynthetic Process Negative Regulation Of Circadian Rhythm Regulation Of Appetite Regulation Of Interleukin-6 Biosynthetic Process G-protein Coupled Receptor Signaling Pathway Decidualization Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Synapse Assembly Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Interleukin-6 Production Negative Regulation Of Cytokine Biosynthetic Process Negative Regulation Of Insulin Secretion Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Negative Regulation Of Peptide Secretion Maternal Placenta Development Regulation Of Interleukin-1 Beta Production Positive Regulation Of Multicellular Organism Growth Acid Secretion Positive Regulation Of Lipid Transport Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Synapse Assembly Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Hormone Secretion Positive Regulation Of Insulin Secretion
Tagcloud ?		breeding broiler bw bw49 bw70 bwg chickens desorption fcr feed fi flight genotyped ghrelin ghsr haplotypes igf1r maldi meanwhile rs14011776 rs14011780 rs14011783 rs14678932 rs14986828 rs15675065 rs15675067 rs16675844 snps yellow	aa aspergillus awamori basal broiler chicks cholesterol conversion cpu crude diets digestibility dmd dry fed feed feeding fos fructooligosaccharide hdl igf1r improves lipoprotein matter secretagogue skeletal supplementation supplemented utilization
Tagcloud (Difference) ?		breeding bw bw49 bw70 bwg chickens desorption fcr fi flight genotyped ghrelin haplotypes maldi meanwhile rs14011776 rs14011780 rs14011783 rs14678932 rs14986828 rs15675065 rs15675067 rs16675844 snps yellow	aa aspergillus awamori basal chicks cholesterol conversion cpu crude diets digestibility dmd dry fed feeding fos fructooligosaccharide hdl improves lipoprotein matter secretagogue skeletal supplementation supplemented utilization
Tagcloud (Intersection) ?		broiler feed ghsr igf1r