GHRL and GHRHR

Number of citations of the paper that reports this interaction (PubMedID 10461027)
0

Data Source:
HPRD (in vivo)

		GHRL	GHRHR
Description		ghrelin and obestatin prepropeptide	growth hormone releasing hormone receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Axon Secretory Granule Lumen Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse Neuronal Dense Core Vesicle Lumen	Nuclear Inner Membrane Nuclear Outer Membrane Cytoplasm Plasma Membrane Cell Surface Membrane Nuclear Matrix Secretory Granule Sarcolemma
	Molecular Function	G Protein-coupled Receptor Binding Hormone Activity Protein Binding Growth Hormone-releasing Hormone Activity Protein Tyrosine Kinase Activator Activity Ghrelin Receptor Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Growth Hormone-releasing Hormone Receptor Activity Peptide Hormone Binding Growth Factor Binding
	Biological Process	Gastric Acid Secretion Negative Regulation Of Endothelial Cell Proliferation G Protein-coupled Receptor Internalization Glucose Metabolic Process G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Synapse Assembly Actin Polymerization Or Depolymerization Adult Feeding Behavior Response To Hormone Hormone-mediated Signaling Pathway Dendrite Development Negative Regulation Of Angiogenesis Growth Hormone Secretion Response To Nutrient Levels Positive Regulation Of Insulin Secretion Regulation Of Response To Food Positive Regulation Of Response To Food Positive Regulation Of Appetite Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Growth Rate Negative Regulation Of Locomotion Positive Regulation Of Multicellular Organism Growth Regulation Of Cell Population Proliferation Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Negative Regulation Of Apoptotic Process Cortisol Secretion Positive Regulation Of MAPK Cascade Response To Estrogen Positive Regulation Of Growth Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Insulin Secretion Decidualization Negative Regulation Of Inflammatory Response Cartilage Development Positive Regulation Of Corticotropin Secretion Positive Regulation Of Cortisol Secretion Response To Electrical Stimulus Positive Regulation Of Synapse Assembly Regulation Of Transmission Of Nerve Impulse Excitatory Postsynaptic Potential Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Growth Hormone Receptor Signaling Pathway Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynapse Organization Positive Regulation Of Small Intestinal Transit Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Bone Development Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Eating Behavior Positive Regulation Of Adipose Tissue Development Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Positive Regulation Of Gastric Mucosal Blood Circulation Positive Regulation Of Small Intestine Smooth Muscle Contraction Regulation Of Gastric Motility Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Feeding Behavior	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Lactation Positive Regulation Of Cell Population Proliferation Determination Of Adult Lifespan Adenohypophysis Development Growth Hormone Secretion Mammary Gland Development Response To Insulin Cellular Response To Insulin Stimulus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Multicellular Organism Growth Hormone Metabolic Process Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Estrogen Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Hormone Secretion Positive Regulation Of Hormone Secretion Cell Maturation Regulation Of Protein Metabolic Process Response To Glucocorticoid Establishment Of Localization In Cell Positive Regulation Of Growth Hormone Secretion Somatotropin Secreting Cell Development Cellular Response To Glucose Stimulus CAMP/PKA Signal Transduction
Pathways			G alpha (s) signalling events Glucagon-type ligand receptors
Drugs			Sermorelin Tesamorelin
Diseases			Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) ghrelin levels ( 33852427)	Triglyceride levels ( 34074324)
Interacting Genes		9 interacting genes: ACE2 AGRP GHRHR GHSR LEP MLNR NPY UBQLN1 UBQLN2	3 interacting genes: GHRH GHRL MLNR
Entrez ID		51738	2692
HPRD ID		05638	00748
Ensembl ID		ENSG00000157017	ENSG00000106128
Uniprot IDs		Q9UBU3	A0A090N8Y6 Q02643
PDB IDs		6H3E 7F9Y 7NA7 7W2Z	2XDG 7CZ5
Enriched GO Terms of Interacting Partners?		Adult Feeding Behavior Feeding Behavior Positive Regulation Of Behavior Positive Regulation Of Feeding Behavior Regulation Of Behavior Regulation Of Response To Food Regulation Of Appetite Regulation Of Feeding Behavior Growth Hormone-releasing Hormone Receptor Activity Regulation Of Response To Nutrient Levels Adult Behavior Positive Regulation Of Eating Behavior Positive Regulation Of Response To Food Positive Regulation Of Appetite Response To Insulin Growth Hormone Secretion Regulation Of Eating Behavior Peptide Hormone Secretion Regulation Of Transport Peptide Secretion Regulation Of Amine Transport Hormone Secretion Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Appetite Response To Peptide Hormone Regulation Of Growth Hormone Secretion Cellular Response To Insulin Stimulus Peptide Transport Hormone Transport Hormone Binding Positive Regulation Of ERAD Pathway G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Amide Transport Regulation Of Defense Response Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Transport Regulation Of ERAD Pathway Signal Release Positive Regulation Of Developmental Growth Photoperiodism Regulation Of Blood Pressure Neuropeptide Hormone Activity Cellular Response To Peptide Hormone Stimulus Eating Behavior Maternal Process Involved In Female Pregnancy Positive Regulation Of Multicellular Organism Growth Hormone Metabolic Process Determination Of Adult Lifespan Positive Regulation Of Multicellular Organismal Process	Growth Hormone-releasing Hormone Activity Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Growth Hormone Secretion Positive Regulation Of Growth Hormone Secretion Regulation Of Growth Hormone Secretion Positive Regulation Of Circadian Rhythm Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle Positive Regulation Of Behavior Positive Regulation Of Multicellular Organism Growth Regulation Of Multicellular Organism Growth Peptide Hormone Secretion Regulation Of Behavior Peptide Secretion Hormone Secretion G Protein-coupled Receptor Signaling Pathway Peptide Transport Hormone Transport Positive Regulation Of Peptide Hormone Secretion Regulation Of Circadian Rhythm Positive Regulation Of Peptide Secretion Hormone Activity Positive Regulation Of Circadian Sleep/wake Cycle, REM Sleep Growth Hormone-releasing Hormone Receptor Binding Ghrelin Receptor Binding Cortisol Secretion Positive Regulation Of Gastric Mucosal Blood Circulation Amide Transport Positive Regulation Of Hormone Secretion Signal Release Positive Regulation Of Developmental Growth Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Small Intestinal Transit Positive Regulation Of Growth Rate Regulation Of Peptide Hormone Secretion Positive Regulation Of Small Intestine Smooth Muscle Contraction Positive Regulation Of Bone Development Positive Regulation Of Growth Hormone Receptor Signaling Pathway Regulation Of Hormone Secretion Positive Regulation Of Growth Positive Regulation Of Eating Behavior Positive Regulation Of Cortisol Secretion Positive Regulation Of Response To Food Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Appetite Regulation Of Gastric Motility Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Secretion By Cell Neuronal Dense Core Vesicle Lumen
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