GHRL and GHRHR

Number of citations of the paper that reports this interaction (PMID 10461027)
1

Data Source:
HPRD (in vivo)

		GHRL	GHRHR
Gene Name		ghrelin/obestatin prepropeptide	growth hormone releasing hormone receptor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Axon Secretory Granule Lumen	Nuclear Inner Membrane Nuclear Outer Membrane Cytoplasm Plasma Membrane Cell Surface Integral Component Of Membrane Nuclear Matrix Secretory Granule
	Molecular Function	G-protein Coupled Receptor Binding Growth Hormone-releasing Hormone Activity Protein Tyrosine Kinase Activator Activity Ghrelin Receptor Binding	G-protein Coupled Receptor Activity Protein Binding Growth Hormone-releasing Hormone Receptor Activity Peptide Hormone Binding Growth Factor Binding
	Biological Process	Activation Of MAPK Activity Gastric Acid Secretion Negative Regulation Of Endothelial Cell Proliferation Glucose Metabolic Process G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Actin Polymerization Or Depolymerization Adult Feeding Behavior Response To Hormone Hormone-mediated Signaling Pathway Dendrite Development Negative Regulation Of Angiogenesis Growth Hormone Secretion Positive Regulation Of Insulin Secretion Regulation Of Response To Food Positive Regulation Of Appetite Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Locomotion Positive Regulation Of Multicellular Organism Growth Regulation Of Cell Proliferation Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Negative Regulation Of Apoptotic Process Cortisol Secretion Response To Estrogen Cellular Protein Metabolic Process Negative Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Insulin Secretion Decidualization Negative Regulation Of Inflammatory Response Cartilage Development Positive Regulation Of Corticotropin Secretion Positive Regulation Of Cortisol Secretion Positive Regulation Of Synapse Assembly Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity	Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Lactation Positive Regulation Of Cell Proliferation Determination Of Adult Lifespan CAMP-mediated Signaling Water Homeostasis Growth Hormone Secretion Positive Regulation Of CAMP Biosynthetic Process Response To Insulin Cellular Response To Insulin Stimulus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Multicellular Organism Growth Hormone Metabolic Process Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Estrogen Cell Maturation Multicellular Organismal Reproductive Process Regulation Of Protein Metabolic Process Response To Glucocorticoid Positive Regulation Of Growth Hormone Secretion Somatotropin Secreting Cell Development
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs			Sermorelin Tesamorelin
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ACE2 AGRP GHRHR GHSR LEP MLNR NPY UBQLN1	3 interactors: GHRH GHRL MLNR
Entrez ID		51738	2692
HPRD ID		05638	00748
Ensembl ID		ENSG00000157017	ENSG00000106128
Uniprot IDs		Q9UBU3	Q02643
PDB IDs		1P7X	2XDG
Enriched GO Terms of Interacting Partners?		Adult Feeding Behavior Feeding Behavior Regulation Of Response To Food Regulation Of Appetite Adult Behavior Behavior Female Pregnancy Positive Regulation Of Appetite Regulation Of Hormone Levels Peptide Hormone Secretion Peptide Secretion Response To Insulin Maternal Process Involved In Female Pregnancy Multicellular Organismal Reproductive Process Hormone Secretion Multicellular Organism Reproduction Hormone Transport Peptide Transport Growth Hormone Secretion Digestion Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Reproduction Single-organism Behavior Response To Peptide Hormone Amide Transport Response To Peptide G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Developmental Growth Regulation Of Blood Pressure Cellular Response To Hormone Stimulus Hormone Metabolic Process Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Reproductive Process Regulation Of Peptide Hormone Secretion Eating Behavior Positive Regulation Of Growth Regulation Of Hormone Secretion Negative Regulation Of Peptide Secretion Response To Organonitrogen Compound Regulation Of Developmental Growth Cell Surface Receptor Signaling Pathway Blood Circulation Cell-cell Signaling Positive Regulation Of Multicellular Organism Growth Response To Hormone Regulation Of Vasoconstriction Negative Regulation Of Hormone Secretion Response To Stimulus Regulation Of Protein Metabolic Process Response To Nutrient Levels	Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Growth Hormone Secretion Regulation Of Growth Hormone Secretion Growth Hormone Secretion Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Circadian Rhythm Positive Regulation Of Multicellular Organism Growth Peptide Hormone Secretion Peptide Secretion Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Hormone Secretion Hormone Transport Peptide Transport Regulation Of Circadian Rhythm Regulation Of Multicellular Organism Growth Positive Regulation Of Hormone Secretion Digestion Positive Regulation Of Behavior Amide Transport G-protein Coupled Receptor Signaling Pathway Cortisol Secretion Positive Regulation Of Developmental Growth Regulation Of Behavior Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Regulation Of Peptide Hormone Secretion Positive Regulation Of Growth Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Hormone Secretion Regulation Of Hormone Levels Regulation Of Developmental Growth Positive Regulation Of Cortisol Secretion Positive Regulation Of Corticotropin Secretion Positive Regulation Of Appetite Positive Regulation Of Secretion Regulation Of Corticotropin Secretion Regulation Of Growth Hormone Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Interleukin-6 Biosynthetic Process Response To Nutrient Levels Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Adult Feeding Behavior Response To Extracellular Stimulus Gastric Acid Secretion Secretion By Cell Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Adenohypophysis Development
Tagcloud ?		breeding broiler bw bw49 bw70 bwg chickens desorption fcr feed fi flight genotyped ghrelin ghsr haplotypes igf1r maldi meanwhile rs14011776 rs14011780 rs14011783 rs14678932 rs14986828 rs15675065 rs15675067 rs16675844 snps yellow	abeta appswe autosomal dark deprivation diurnal fluctuation interstitial intracerebroventricular intraperitoneal isf lit manipulating microdialysis neurofibrillary orexin overexpress possibilities ps1app ps1deltae9 psen1 releasing sleep substance tangles wake wakefulness
Tagcloud (Difference) ?		breeding broiler bw bw49 bw70 bwg chickens desorption fcr feed fi flight genotyped ghrelin ghsr haplotypes igf1r maldi meanwhile rs14011776 rs14011780 rs14011783 rs14678932 rs14986828 rs15675065 rs15675067 rs16675844 snps yellow	abeta appswe autosomal dark deprivation diurnal fluctuation interstitial intracerebroventricular intraperitoneal isf lit manipulating microdialysis neurofibrillary orexin overexpress possibilities ps1app ps1deltae9 psen1 releasing sleep substance tangles wake wakefulness
Tagcloud (Intersection) ?